The Function of BCL3
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.
Protein names
Recommended name:
B-cell lymphoma 3 proteinShort name:
BCL-3Alternative name(s):
Proto-oncogene BCL3- RS4803750 (BCL3) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase BCL3
| Substances | Interaction | Organism | Category |
Substances That Decrease BCL3
| Substances | Interaction | Organism | Category |
Advanced Summary
From UniProt: A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
From NCBI Gene: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008] From UniProt: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Caution:
It is uncertain whether Met-1 or Met-9 is the initiator.
Molecular Function:
- Dna Binding
- Protein Binding, Bridging
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
Biological Processes:
- Antimicrobial Humoral Response
- Cellular Response To Dna Damage Stimulus
- Defense Response To Bacterium
- Defense Response To Protozoan
- Dna Damage Response, Signal Transduction By P53 Class Mediator
- Extracellular Matrix Organization
- Follicular Dendritic Cell Differentiation
- Germinal Center Formation
- Humoral Immune Response Mediated By Circulating Immunoglobulin
- I-Kappab Kinase/Nf-Kappab Signaling
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage By P53 Class Mediator
- Maintenance Of Protein Location In Nucleus
- Marginal Zone B Cell Differentiation
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Interleukin-8 Biosynthetic Process
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-10 Biosynthetic Process
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Translation
- Protein Import Into Nucleus, Translocation
- Regulation Of Apoptotic Process
- Regulation Of Dna Binding
- Regulation Of Nf-Kappab Import Into Nucleus
- Response To Uv-C
- Response To Virus
- Spleen Development
- T-Helper 1 Type Immune Response
- T-Helper 2 Cell Differentiation
- Transcription, Dna-Templated