The Function of BAX
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
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Protein names
Recommended name:
Apoptosis regulator BAXAlternative name(s):
Bcl-2-like protein 4Bcl2-L-4
- RS4645878 (BAX) ??
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Top Gene-Substance Interactions
BAX Interacts with These Diseases
| Disease | Score |
Substances That Increase BAX
| Substances | Interaction | Organism | Category |
Substances That Decrease BAX
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
Gene Pathways:
Molecular Function:
- Bh3 Domain Binding
- Channel Activity
- Identical Protein Binding
- Lipid Binding
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
Biological Processes:
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
- Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
- Apoptotic Mitochondrial Changes
- Apoptotic Process
- Apoptotic Process Involved In Embryonic Digit Morphogenesis
- Apoptotic Process Involved In Blood Vessel Morphogenesis
- Apoptotic Signaling Pathway
- B Cell Apoptotic Process
- B Cell Homeostasis
- B Cell Homeostatic Proliferation
- B Cell Negative Selection
- B Cell Receptor Apoptotic Signaling Pathway
- Blood Vessel Remodeling
- Cellular Response To Uv
- Cerebral Cortex Development
- Development Of Secondary Sexual Characteristics
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
- Ectopic Germ Cell Programmed Cell Death
- Endoplasmic Reticulum Calcium Ion Homeostasis
- Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
- Extrinsic Apoptotic Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Fertilization
- Germ Cell Development
- Glycosphingolipid Metabolic Process
- Homeostasis Of Number Of Cells Within A Tissue
- Hypothalamus Development
- Intrinsic Apoptotic Signaling Pathway
- Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
- Kidney Development
- Mitochondrial Fragmentation Involved In Apoptotic Process
- Mitochondrial Fusion
- Mitochondrion Morphogenesis
- Myeloid Cell Homeostasis
- Negative Regulation Of Apoptotic Signaling Pathway
- Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
- Negative Regulation Of Fibroblast Proliferation
- Negative Regulation Of Neuron Apoptotic Process
- Negative Regulation Of Peptidyl-Serine Phosphorylation
- Neuron Apoptotic Process
- Neuron Migration
- Odontogenesis Of Dentin-Containing Tooth
- Ovarian Follicle Development
- Positive Regulation Of Apoptotic Dna Fragmentation
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
- Positive Regulation Of B Cell Apoptotic Process
- Positive Regulation Of Developmental Pigmentation
- Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
- Positive Regulation Of Ire1-Mediated Unfolded Protein Response
- Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
- Positive Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Protein Oligomerization
- Positive Regulation Of Release Of Cytochrome C From Mitochondria
- Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
- Post-Embryonic Camera-Type Eye Morphogenesis
- Protein Homooligomerization
- Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
- Protein Oligomerization
- Regulation Of Apoptotic Process
- Regulation Of Mammary Gland Epithelial Cell Proliferation
- Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death
- Regulation Of Mitochondrial Membrane Potential
- Regulation Of Nitrogen Utilization
- Regulation Of Protein Heterodimerization Activity
- Regulation Of Protein Homodimerization Activity
- Release Of Cytochrome C From Mitochondria
- Release Of Matrix Enzymes From Mitochondria
- Response To Axon Injury
- Response To Gamma Radiation
- Response To Salt Stress
- Response To Toxic Substance
- Retina Development In Camera-Type Eye
- Retinal Cell Programmed Cell Death
- Sertoli Cell Proliferation
- Spermatid Differentiation
- T Cell Homeostatic Proliferation
- Thymocyte Apoptotic Process
- Vagina Development
- Viral Process
- Aging
- Cellular Respiration
- Glial Cell Apoptotic Process
- Inner Mitochondrial Membrane Organization
- Outer Mitochondrial Membrane Organization
- Response To Cocaine
- Response To Copper Ion
- Response To Corticosterone