The Function of BAX
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
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Protein names
Recommended name:
Apoptosis regulator BAXAlternative name(s):
Bcl-2-like protein 4Bcl2-L-4
- RS4645878 (BAX) ??
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Top Gene-Substance Interactions
BAX Interacts with These Diseases
| Disease | Score |
Substances That Increase BAX
| Substances | Interaction | Organism | Category |
Substances That Decrease BAX
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
Gene Pathways:
Molecular Function:
- Lipid Binding
- Channel Activity
- Identical Protein Binding
- Protein Homodimerization Activity
- Protein Heterodimerization Activity
- Bh3 Domain Binding
Biological Processes:
- Ovarian Follicle Development
- Neuron Migration
- T Cell Homeostatic Proliferation
- B Cell Homeostasis
- B Cell Apoptotic Process
- Kidney Development
- Release Of Cytochrome C From Mitochondria
- Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
- Blood Vessel Remodeling
- Myeloid Cell Homeostasis
- B Cell Negative Selection
- B Cell Homeostatic Proliferation
- Positive Regulation Of B Cell Apoptotic Process
- Glycosphingolipid Metabolic Process
- Regulation Of Nitrogen Utilization
- Apoptotic Process
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
- Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
- Inner Mitochondrial Membrane Organization
- Outer Mitochondrial Membrane Organization
- Germ Cell Development
- Aging
- Mitochondrial Fusion
- Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
- Apoptotic Mitochondrial Changes
- Fertilization
- Response To Toxic Substance
- Response To Salt Stress
- Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
- Response To Gamma Radiation
- Viral Process
- Hypothalamus Development
- Cerebral Cortex Development
- Positive Regulation Of Protein Oligomerization
- Endoplasmic Reticulum Calcium Ion Homeostasis
- Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
- Release Of Matrix Enzymes From Mitochondria
- Negative Regulation Of Peptidyl-Serine Phosphorylation
- Regulation Of Mammary Gland Epithelial Cell Proliferation
- Glial Cell Apoptotic Process
- Cellular Response To Uv
- Ectopic Germ Cell Programmed Cell Death
- Response To Cocaine
- Odontogenesis Of Dentin-Containing Tooth
- Regulation Of Apoptotic Process
- Positive Regulation Of Apoptotic Process
- Regulation Of Protein Homodimerization Activity
- Regulation Of Protein Heterodimerization Activity
- Negative Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Neuron Apoptotic Process
- Mitochondrial Fragmentation Involved In Apoptotic Process
- Development Of Secondary Sexual Characteristics
- Cellular Respiration
- Retinal Cell Programmed Cell Death
- Response To Copper Ion
- Positive Regulation Of Developmental Pigmentation
- Negative Regulation Of Fibroblast Proliferation
- Spermatid Differentiation
- Post-Embryonic Camera-Type Eye Morphogenesis
- Response To Axon Injury
- Homeostasis Of Number Of Cells Within A Tissue
- Protein Oligomerization
- Protein Homooligomerization
- Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
- Neuron Apoptotic Process
- Response To Corticosterone
- Regulation Of Mitochondrial Membrane Potential
- Sertoli Cell Proliferation
- Retina Development In Camera-Type Eye
- Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
- Vagina Development
- Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
- Thymocyte Apoptotic Process
- Mitochondrion Morphogenesis
- Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
- Positive Regulation Of Release Of Cytochrome C From Mitochondria
- Apoptotic Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Intrinsic Apoptotic Signaling Pathway
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
- Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
- Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
- Apoptotic Process Involved In Blood Vessel Morphogenesis
- Apoptotic Process Involved In Embryonic Digit Morphogenesis
- Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death
- Positive Regulation Of Apoptotic Dna Fragmentation
- Positive Regulation Of Ire1-Mediated Unfolded Protein Response
- B Cell Receptor Apoptotic Signaling Pathway
- Negative Regulation Of Apoptotic Signaling Pathway
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Positive Regulation Of Intrinsic Apoptotic Signaling Pathway