The Function of BAP1
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
Protein names
Recommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1Alternative name(s):
BRCA1-associated protein 1Cerebral protein 6
Top Gene-Substance Interactions
BAP1 Interacts with These Diseases
Disease | Score |
Substances That Increase BAP1
Substances | Interaction | Organism | Category |
Substances That Decrease BAP1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in testis, placenta and ovary. Expressed in breast.
Molecular Function:
Biological Processes:
- Cellular Protein Modification Process
- Monoubiquitinated Histone H2a Deubiquitination
- Monoubiquitinated Protein Deubiquitination
- Negative Regulation Of Cell Proliferation
- Positive Regulation Of Protein Targeting To Mitochondrion
- Protein Deubiquitination
- Protein K48-Linked Deubiquitination
- Regulation Of Cell Cycle
- Regulation Of Cell Growth
- Ubiquitin-Dependent Protein Catabolic Process