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  3. BAP1

BAP1 (BRCA1 associated protein 1)

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The Function of BAP1

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

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Protein names

Recommended name:

Ubiquitin carboxyl-terminal hydrolase BAP1

Alternative name(s):

BRCA1-associated protein 1
Cerebral protein 6

Top Gene-Substance Interactions

BAP1 Interacts with These Diseases

Disease Score

Substances That Increase BAP1

Substances Interaction Organism Category

Substances That Decrease BAP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Sp1
  • p300

Tissue specificity:

Highly expressed in testis, placenta and ovary. Expressed in breast.

Molecular Function:

  • Chromatin Binding
  • Peptidase Activity
  • Thiol-Dependent Ubiquitin-Specific Protease Activity

Biological Processes:

  • Cellular Protein Modification Process
  • Monoubiquitinated Histone H2a Deubiquitination
  • Monoubiquitinated Protein Deubiquitination
  • Negative Regulation Of Cell Proliferation
  • Positive Regulation Of Protein Targeting To Mitochondrion
  • Protein Deubiquitination
  • Protein K48-Linked Deubiquitination
  • Regulation Of Cell Cycle
  • Regulation Of Cell Growth
  • Ubiquitin-Dependent Protein Catabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07792| AS27_09717| BAI1-associated protein 3| BAIAP3| BRCA1-associated protein 1| BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase| BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)| CB1_000460016| cerebral protein-13| cerebral protein 6| EGK_16683| GW7_01604| hucep-13| hucep-6| M959_01310| MDA_GLEAN10007838| N301_15047| N302_10123| N303_08669| N305_08463| N306_01619| N307_03505| N308_14172| N309_08964| N320_05730| N324_12630| N326_06213| N327_07239| N328_07974| N330_10480| N331_08269| N332_09160| N334_09122| N336_02950| N341_09117| PAL_GLEAN10022232| PANDA_007582| TREES_T100010309| ubiquitin carboxyl-terminal hydrolase BAP1| ubiquitin carboxy-terminal hydrolase| ubiquitin C-terminal hydrolase X4| UCHL2| uch-x4| UY3_08961| Y1Q_024643| Y956_07439| Z169_04573| bap1

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