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  3. BAK1

BAK1 (BCL2 antagonist/killer 1)

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The Function of BAK1

In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

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Protein names

Recommended name:

Bcl-2 homologous antagonist/killer

Alternative name(s):

Apoptosis regulator BAK
Bcl-2-like protein 7
Bcl2-L-7

BAK1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS210134 (BAK1) ??
  2. RS210135 (BAK1) ??
  3. RS210138 (BAK1) ??
  4. RS210142 (BAK1) ??
  5. RS210152 (BAK1) ??
  6. RS513349 (BAK1) ??
  7. RS5745568 (BAK1) ??
  8. RS6457730 (BAK1) ??
  9. RS6910233 (BAK1) ??
  10. RS7747216 (BAK1) ??
  11. RS9296092 (BAK1) ??
  12. RS9296095 (BAK1) ??
  13. RS9394152 (BAK1) ??
  14. RS9469457 (BAK1) ??

Top Gene-Substance Interactions

BAK1 Interacts with These Diseases

Disease Score

Substances That Increase BAK1

Substances Interaction Organism Category

Substances That Decrease BAK1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • c-Myc
  • Sp1
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • Egr-2

Tissue specificity:

Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.

Gene Pathways:

  • Apoptosis
  • Protein processing in endoplasmic reticulum

Molecular Function:

  • Identical Protein Binding
  • Ion Channel Binding
  • Metal Ion Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Activation Of Cysteine-Type Endopeptidase Activity
  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
  • Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
  • Aging
  • Animal Organ Regeneration
  • Apoptotic Process Involved In Blood Vessel Morphogenesis
  • Apoptotic Signaling Pathway
  • B Cell Apoptotic Process
  • B Cell Homeostasis
  • B Cell Negative Selection
  • Blood Vessel Remodeling
  • Brain Development
  • Cell Proliferation
  • Cellular Response To Mechanical Stimulus
  • Cellular Response To Uv
  • Cytolysis
  • Endocrine Pancreas Development
  • Endoplasmic Reticulum Calcium Ion Homeostasis
  • Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
  • Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
  • Fibroblast Apoptotic Process
  • Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
  • Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
  • Limb Morphogenesis
  • Mitochondrial Fusion
  • Myeloid Cell Homeostasis
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Peptidyl-Serine Phosphorylation
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Calcium Ion Transport Into Cytosol
  • Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
  • Positive Regulation Of Ire1-Mediated Unfolded Protein Response
  • Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
  • Positive Regulation Of Proteolysis
  • Positive Regulation Of Release Of Cytochrome C From Mitochondria
  • Post-Embryonic Camera-Type Eye Morphogenesis
  • Regulation Of Cell Cycle
  • Regulation Of Mitochondrial Membrane Permeability
  • Regulation Of Mitochondrial Membrane Potential
  • Regulation Of Protein Heterodimerization Activity
  • Regulation Of Protein Homodimerization Activity
  • Release Of Cytochrome C From Mitochondria
  • Response To Ethanol
  • Response To Fungus
  • Response To Gamma Radiation
  • Response To Hydrogen Peroxide
  • Response To Mycotoxin
  • Response To Organic Cyclic Compound
  • Response To Uv-C
  • Thymocyte Apoptotic Process
  • Vagina Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| A306_14748| apoptosis regulator BAK| AS27_02050| AS28_04631| BAK| BAK-LIKE| BCL2-antagonist| BCL2-antagonist/killer 1| Bcl-2 homologous antagonist/killer| Bcl2 homologous antagonist/killer| bcl-2 homologous antagonist/killer-like| bcl2-L-7| BCL2L7| Bcl-2-like 7| BCL2-like 7 protein| Bcl-2-likeous antagonist/killer| bcl-2-like protein 7| Bcl-2 like protein antagonist/killer| Bcl-2-like protein antagonist/killer| Bcl-2 like proteinous antagonist/killer| bcl-2ous antagonist/killer-like protein| CB1_000487033| CDN1| GW7_09865| H920_15466| M91_02581| M959_13733| MDA_GLEAN10006840| N300_03764| N301_06639| N302_14744| N303_11110| N305_13596| N306_01151| N307_09711| N308_11476| N309_03230| N310_07516| N311_08346| N312_06991| N321_02270| N322_03271| N324_05463| N325_04196| N327_03577| N328_06791| N329_10120| N330_02326| N331_09049| N332_05244| N334_14263| N335_05816| N336_07799| N340_12377| N-Bak| N-BAK1| PAL_GLEAN10007091| PANDA_002259| pro-apoptotic protein BAK| Putative Bcl-2 homologous antagonist/killer 2| Putative Bcl-2 like protein antagonist/killer 2| Putative Bcl-2-like protein antagonist/killer 2| translocator protein-like| TREES_T100009718| UY3_10564| Y1Q_012712| Y956_10855| Z169_00372| bak1

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