The Function of BAK1
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
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Protein names
Recommended name:
Bcl-2 homologous antagonist/killerAlternative name(s):
Apoptosis regulator BAKBcl-2-like protein 7
Bcl2-L-7
- RS210134 (BAK1) ??
- RS210135 (BAK1) ??
- RS210138 (BAK1) ??
- RS210142 (BAK1) ??
- RS210152 (BAK1) ??
- RS513349 (BAK1) ??
- RS5745568 (BAK1) ??
- RS6457730 (BAK1) ??
- RS6910233 (BAK1) ??
- RS7747216 (BAK1) ??
- RS9296092 (BAK1) ??
- RS9296095 (BAK1) ??
- RS9394152 (BAK1) ??
- RS9469457 (BAK1) ??
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Top Gene-Substance Interactions
BAK1 Interacts with These Diseases
| Disease | Score |
Substances That Increase BAK1
| Substances | Interaction | Organism | Category |
Substances That Decrease BAK1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Gene Pathways:
Molecular Function:
- Identical Protein Binding
- Ion Channel Binding
- Metal Ion Binding
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
Biological Processes:
- Activation Of Cysteine-Type Endopeptidase Activity
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
- Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
- Aging
- Animal Organ Regeneration
- Apoptotic Process Involved In Blood Vessel Morphogenesis
- Apoptotic Signaling Pathway
- B Cell Apoptotic Process
- B Cell Homeostasis
- B Cell Negative Selection
- Blood Vessel Remodeling
- Brain Development
- Cell Proliferation
- Cellular Response To Mechanical Stimulus
- Cellular Response To Uv
- Cytolysis
- Endocrine Pancreas Development
- Endoplasmic Reticulum Calcium Ion Homeostasis
- Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Fibroblast Apoptotic Process
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
- Limb Morphogenesis
- Mitochondrial Fusion
- Myeloid Cell Homeostasis
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
- Negative Regulation Of Gene Expression
- Negative Regulation Of Peptidyl-Serine Phosphorylation
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Calcium Ion Transport Into Cytosol
- Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
- Positive Regulation Of Ire1-Mediated Unfolded Protein Response
- Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
- Positive Regulation Of Proteolysis
- Positive Regulation Of Release Of Cytochrome C From Mitochondria
- Post-Embryonic Camera-Type Eye Morphogenesis
- Regulation Of Cell Cycle
- Regulation Of Mitochondrial Membrane Permeability
- Regulation Of Mitochondrial Membrane Potential
- Regulation Of Protein Heterodimerization Activity
- Regulation Of Protein Homodimerization Activity
- Release Of Cytochrome C From Mitochondria
- Response To Ethanol
- Response To Fungus
- Response To Gamma Radiation
- Response To Hydrogen Peroxide
- Response To Mycotoxin
- Response To Organic Cyclic Compound
- Response To Uv-C
- Thymocyte Apoptotic Process
- Vagina Development