• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. BAAT

BAAT (Bile acid-CoA:amino acid N-acyltransferase)

Loading...

The Function of BAAT

Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Bile acid-CoA:amino acid N-acyltransferase

Short name:

BAT

Alternative name(s):

BACAT
Glycine N-choloyltransferase
Long-chain fatty-acyl-CoA hydrolase

BAAT SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1572983 (BAAT) ??

Top Gene-Substance Interactions

Substances That Increase BAAT

Substances Interaction Organism Category

Substances That Decrease BAAT

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Hypercholanemia, familialFrom UniProt: Familial hypercholanemia (FHCA): A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. [MIM:607748]

     From NCBI Gene: The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] From UniProt: Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Expressed in liver, gallbladder mucosa and pancreas.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Peroxisome
  • Bile secretion
  • Primary bile acid biosynthesis
  • Taurine and hypotaurine metabolism
  • Biosynthesis of unsaturated fatty acids

Molecular Function:

  • Carboxylic Ester Hydrolase Activity
  • Glycine N-Choloyltransferase Activity
  • Long-Chain Acyl-Coa Hydrolase Activity
  • Medium-Chain Acyl-Coa Hydrolase Activity
  • N-Acyltransferase Activity
  • Palmitoyl-Coa Hydrolase Activity
  • Receptor Binding
  • Transferase Activity, Transferring Acyl Groups
  • Very Long Chain Acyl-Coa Hydrolase Activity

Biological Processes:

  • Acyl-Coa Metabolic Process
  • Animal Organ Regeneration
  • Bile Acid Biosynthetic Process
  • Bile Acid Conjugation
  • Bile Acid Metabolic Process
  • Fatty Acid Metabolic Process
  • Glycine Metabolic Process
  • Liver Development
  • Taurine Metabolic Process

Drug Bank:

  • Glycine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Acyl-coenzyme A amino acid N-acyltransferase 1| Acyl-coenzyme A amino acid N-acyltransferase 2| BACAT| BAT| bile acid CoA:amino acid N-acyltransferase| bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)| bile acid Coenzyme A: amino acid N-acyltransferase| bile acid-Coenzyme A: amino acid N-acyltransferase| bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)| bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase| CB1_000794008| glycine N-choloyltransferase| H920_19529| kan-1| long-chain fatty-acyl-CoA hydrolase| N303_13658| N308_12546| N310_09331| PANDA_016170| taurine N-acyltransferase| Y956_13754| Z169_16216| baat

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved