The Function of B4GALT4
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
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Protein names
Recommended name:
Beta-1,4-galactosyltransferase 4Alternative name(s):
Beta-1,4-GalTase 4Beta4Gal-T4
b4Gal-T4
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
Nal synthase
Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
- RS6438504 (B4GALT4) ??
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Top Gene-Substance Interactions
B4GALT4 Interacts with These Diseases
| Disease | Score |
Substances That Increase B4GALT4
| Substances | Interaction | Organism | Category |
Substances That Decrease B4GALT4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
High expression in heart, placenta, kidney and pancreas; lower in brain, colon, lung, muscle, ovary, testis and uterus.
Gene Pathways:
Molecular Function:
- Beta-N-Acetylglucosaminylglycopeptide Beta-1,4-Galactosyltransferase Activity
- N-Acetyllactosamine Synthase Activity
- Galactosyltransferase Activity
- Metal Ion Binding
Biological Processes:
- Carbohydrate Metabolic Process
- Protein Glycosylation
- Membrane Lipid Metabolic Process
- Keratan Sulfate Biosynthetic Process
Drug Bank:
- N-Acetyl-D-Glucosamine