Summary of AVPR1A
Receptor for arginine vasopressin. Has been involved in social behaviors, including affiliation and attachment.
Variations in the vasopressin receptor can alter the risk of substance abuse and marital stability in males [R].
There is an association between genes that have increased AVPR1A gene expression and lower altruism, a higher risk of autism, lower social activity (extraversion) [R+].
For instance, vasopressin has been shown to decrease social communication in male subjects and increase it in female subjects. Vasopressin is more influential in males and oxytocin is more influential in females [R].
In animals, vasopressin helps socializing, whereas in people it may cause social avoidance. The possibility exists in people for a compensatory effect of the dopamine system which can result in higher sociability traits [R].
There's evidence that vasopressin and its receptors can both increase or decrease anxiety [R+].
Protein names
Recommended name:
Vasopressin V1a receptorAlternative name(s):
V1aRAVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
- RS1042615 (AVPR1A) ??
- RS10506458 (AVPR1A) ??
- RS10877945 (AVPR1A) ??
- RS10877969 (AVPR1A) ??
- RS11174811 (AVPR1A) ??
- RS7294536 (AVPR1A) ??
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Top Gene-Substance Interactions
AVPR1A Interacts with These Diseases
Disease | Score |
Substances That Increase AVPR1A
Substances | Interaction | Organism | Category |
Substances That Decrease AVPR1A
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Activation Of Phospholipase C Activity
- Blood Circulation
- Calcium-Mediated Signaling
- Cellular Response To Hormone Stimulus
- Cellular Response To Water Deprivation
- Generation Of Precursor Metabolites And Energy
- G-Protein Coupled Receptor Signaling Pathway
- Grooming Behavior
- Maternal Aggressive Behavior
- Maternal Behavior
- Myotube Differentiation
- Negative Regulation Of Female Receptivity
- Negative Regulation Of Transmission Of Nerve Impulse
- Penile Erection
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cellular Ph Reduction
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Glutamate Secretion
- Positive Regulation Of Heart Rate
- Positive Regulation Of Prostaglandin Biosynthetic Process
- Positive Regulation Of Renal Sodium Excretion
- Positive Regulation Of Systemic Arterial Blood Pressure
- Positive Regulation Of Vasoconstriction
- Regulation Of Systemic Arterial Blood Pressure By Vasopressin
- Response To Corticosterone
- Response To Peptide
- Social Behavior
- Sperm Ejaculation
- Telencephalon Development
Drug Bank:
- Terlipressin
- Desmopressin
- Vasopressin
- Conivaptan
- Felypressin
- Tolvaptan