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  3. AVP

AVP (Arginine vasopressin)

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Summary of AVP

The AVP gene provides instructions for making a hormone called vasopressin or antidiuretic hormone (ADH). The major function of ADH is to help control the body's water balance by determining how much water is excreted in urine. Normally, when a person's fluid intake is low or when a lot of fluid is lost (for example, through sweating), the pituitary gland releases more ADH into the bloodstream. High levels of this hormone direct the kidneys to reabsorb more water and to make less urine. When fluid intake is adequate, the pituitary gland releases less ADH . Lower levels of this hormone cause the kidneys to reabsorb less water and to make more urine.

Vasopressin is involved in cognition, cardiovascular functions, complex sexual and maternal behaviour (R). Vasopressin also causes vasoconstriction of the peripheral vessels.

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Protein names

Recommended name:

Vasopressin-neurophysin 2-copeptin

Short name:

AVP-NPII

Alternative name(s):

Arginine-vasopressin
Neurophysin-II

AVP SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2740204 (AVP) ??

Top Gene-Substance Interactions

AVP Interacts with These Diseases

Disease Score

Substances That Increase AVP

Substances Interaction Organism Category

Substances That Decrease AVP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • c-Jun
  • NF-kappaB1
  • c-Fos
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Transmembrane transport of small molecules
  • Vasopressin-regulated water reabsorption
  • Signal Transduction
  • Mus musculus biological processes
  • Vascular smooth muscle contraction
  • Circadian Clock

Molecular Function:

  • Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
  • Neuropeptide Hormone Activity
  • Receptor Binding
  • Signal Transducer Activity
  • V1a Vasopressin Receptor Binding

Biological Processes:

  • Cell-Cell Signaling
  • Erk1 And Erk2 Cascade
  • Generation Of Precursor Metabolites And Energy
  • Grooming Behavior
  • Hyperosmotic Salinity Response
  • Locomotory Behavior
  • Maternal Aggressive Behavior
  • Maternal Behavior
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Negative Regulation Of Female Receptivity
  • Negative Regulation Of Release Of Cytochrome C From Mitochondria
  • Negative Regulation Of Transmission Of Nerve Impulse
  • Penile Erection
  • Positive Regulation Of Camp Biosynthetic Process
  • Positive Regulation Of Cell Growth
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Cellular Ph Reduction
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Glutamate Secretion
  • Positive Regulation Of Peptidyl-Serine Phosphorylation
  • Positive Regulation Of Prostaglandin Biosynthetic Process
  • Positive Regulation Of Systemic Arterial Blood Pressure
  • Positive Regulation Of Vasoconstriction
  • Protein Kinase C Signaling
  • Regulation Of Renal Sodium Excretion
  • Renal Water Homeostasis
  • Response To Ethanol
  • Response To Nicotine
  • Response To Testosterone
  • Signal Transduction
  • Social Behavior
  • Sodium-Independent Organic Anion Transport
  • Vasoconstriction
  • Water Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ADH| antidiuretic hormone| arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping)| arginine vasopressin (neurophysin 2, antidiuretic hormone, diabetes insipidus, neurohypophyseal)| arginine vasopressin-neurophysin II| arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)| arginine vasotocin| arvp| avpl| AVP-NPII| avrp| AVT| copeptin| DI| neurohypophyseal| neurophysin| neurophysin 2| neurophysin II| PANDA_007362| pre-pro-arginine-vasopressin-neurophysin II| prepro-arginine-vasopressin-neurophysin II| prepro-AVP-NP II| prepropressophysin| preprovasopressin-neurophysin| TREES_T100018101| Vas| vasopressin| Vasopressin-neurophysin 2-copeptin| vasopressin-neurophysin II-copeptin| vasopressin-neurophysin prepropeptide| vasopressin-neurophysin protein| vasotocin| vasotocin neurophysin| vasotocin-neurophysin VT| Vp| vsnp| Vsp| VT-NP| avp

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