Summary of AVP
The AVP gene provides instructions for making a hormone called vasopressin or antidiuretic hormone (ADH). The major function of ADH is to help control the body's water balance by determining how much water is excreted in urine. Normally, when a person's fluid intake is low or when a lot of fluid is lost (for example, through sweating), the pituitary gland releases more ADH into the bloodstream. High levels of this hormone direct the kidneys to reabsorb more water and to make less urine. When fluid intake is adequate, the pituitary gland releases less ADH . Lower levels of this hormone cause the kidneys to reabsorb less water and to make more urine.
Vasopressin is involved in cognition, cardiovascular functions, complex sexual and maternal behaviour (R). Vasopressin also causes vasoconstriction of the peripheral vessels.
Protein names
Recommended name:
Vasopressin-neurophysin 2-copeptinShort name:
AVP-NPIIAlternative name(s):
Arginine-vasopressinNeurophysin-II
- RS2740204 (AVP) ??
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Top Gene-Substance Interactions
AVP Interacts with These Diseases
| Disease | Score |
Substances That Increase AVP
| Substances | Interaction | Organism | Category |
Substances That Decrease AVP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
- Neuropeptide Hormone Activity
- Receptor Binding
- Signal Transducer Activity
- V1a Vasopressin Receptor Binding
Biological Processes:
- Cell-Cell Signaling
- Erk1 And Erk2 Cascade
- Generation Of Precursor Metabolites And Energy
- Grooming Behavior
- Hyperosmotic Salinity Response
- Locomotory Behavior
- Maternal Aggressive Behavior
- Maternal Behavior
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Negative Regulation Of Female Receptivity
- Negative Regulation Of Release Of Cytochrome C From Mitochondria
- Negative Regulation Of Transmission Of Nerve Impulse
- Penile Erection
- Positive Regulation Of Camp Biosynthetic Process
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cellular Ph Reduction
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Gene Expression
- Positive Regulation Of Glutamate Secretion
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Positive Regulation Of Prostaglandin Biosynthetic Process
- Positive Regulation Of Systemic Arterial Blood Pressure
- Positive Regulation Of Vasoconstriction
- Protein Kinase C Signaling
- Regulation Of Renal Sodium Excretion
- Renal Water Homeostasis
- Response To Ethanol
- Response To Nicotine
- Response To Testosterone
- Signal Transduction
- Social Behavior
- Sodium-Independent Organic Anion Transport
- Vasoconstriction
- Water Transport