Summary of AVP
The AVP gene provides instructions for making a hormone called vasopressin or antidiuretic hormone (ADH). The major function of ADH is to help control the body's water balance by determining how much water is excreted in urine. Normally, when a person's fluid intake is low or when a lot of fluid is lost (for example, through sweating), the pituitary gland releases more ADH into the bloodstream. High levels of this hormone direct the kidneys to reabsorb more water and to make less urine. When fluid intake is adequate, the pituitary gland releases less ADH . Lower levels of this hormone cause the kidneys to reabsorb less water and to make more urine.
Vasopressin is involved in cognition, cardiovascular functions, complex sexual and maternal behaviour (R). Vasopressin also causes vasoconstriction of the peripheral vessels.
Protein names
Recommended name:
Vasopressin-neurophysin 2-copeptinShort name:
AVP-NPIIAlternative name(s):
Arginine-vasopressinNeurophysin-II
- RS2740204 (AVP) ??
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Top Gene-Substance Interactions
AVP Interacts with These Diseases
| Disease | Score |
Substances That Increase AVP
| Substances | Interaction | Organism | Category |
Substances That Decrease AVP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Signal Transducer Activity
- Receptor Binding
- Neuropeptide Hormone Activity
- V1a Vasopressin Receptor Binding
- Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Biological Processes:
- Maternal Aggressive Behavior
- Positive Regulation Of Systemic Arterial Blood Pressure
- Renal Water Homeostasis
- Generation Of Precursor Metabolites And Energy
- Water Transport
- Signal Transduction
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Cell-Cell Signaling
- Negative Regulation Of Female Receptivity
- Grooming Behavior
- Locomotory Behavior
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Gene Expression
- Positive Regulation Of Glutamate Secretion
- Positive Regulation Of Cell Growth
- Positive Regulation Of Camp Biosynthetic Process
- Positive Regulation Of Prostaglandin Biosynthetic Process
- Positive Regulation Of Cellular Ph Reduction
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Response To Testosterone
- Response To Nicotine
- Social Behavior
- Regulation Of Renal Sodium Excretion
- Vasoconstriction
- Hyperosmotic Salinity Response
- Maternal Behavior
- Negative Regulation Of Apoptotic Process
- Penile Erection
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Sodium-Independent Organic Anion Transport
- Response To Ethanol
- Positive Regulation Of Vasoconstriction
- Negative Regulation Of Transmission Of Nerve Impulse
- Erk1 And Erk2 Cascade
- Protein Kinase C Signaling
- Negative Regulation Of Release Of Cytochrome C From Mitochondria