The Function of AURKA
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Protein names
Recommended name:
Aurora kinase AShort name:
ARK-1Alternative name(s):
Aurora 2Aurora/IPL1-related kinase 1
Aurora-related kinase 1
hARK1
Breast tumor-amplified kinase
Serine/threonine-protein kinase 15
Serine/threonine-protein kinase 6
Serine/threonine-protein kinase aurora-A
- RS1047972 (AURKA) ??
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Top Gene-Substance Interactions
AURKA Interacts with These Diseases
| Disease | Score |
Substances That Increase AURKA
| Substances | Interaction | Organism | Category |
Substances That Decrease AURKA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Gene Pathways:
Induction:
Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.
Caution:
Authors initially considered AURKA/STK6 and STK15 as 2 different proteins (PubMed:9771714). It is clear that they are the same protein.
Enzyme Regulation:
Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO.
Molecular Function:
- Atp Binding
- Histone Serine Kinase Activity
- Protein Kinase Binding
- Protein Serine/Threonine/Tyrosine Kinase Activity
- Protein Serine/Threonine Kinase Activity
Biological Processes:
- Anaphase-Promoting Complex-Dependent Catabolic Process
- Anterior/Posterior Axis Specification
- Cell Division
- Centrosome Localization
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
- G2/M Transition Of Mitotic Cell Cycle
- Liver Regeneration
- Meiotic Spindle Organization
- Mitotic Centrosome Separation
- Mitotic Nuclear Division
- Mitotic Spindle Organization
- Negative Regulation Of Apoptotic Process
- Neuron Projection Extension
- Positive Regulation Of Mitotic Nuclear Division
- Positive Regulation Of Oocyte Maturation
- Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
- Protein Autophosphorylation
- Protein Localization To Centrosome
- Protein Phosphorylation
- Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
- Regulation Of Centrosome Cycle
- Regulation Of Cytokinesis
- Regulation Of Protein Stability
- Regulation Of Signal Transduction By P53 Class Mediator
- Response To Wounding
- Spindle Assembly Involved In Female Meiosis I
- Spindle Organization
- Response To Estradiol