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  3. ATP6V0D2

ATP6V0D2 (ATPase H+ transporting V0 subunit d2)

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The Function of ATP6V0D2

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis.

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Protein names

Recommended name:

V-type proton ATPase subunit d 2

Alternative name(s):

V-ATPase subunit d 2
Vacuolar proton pump subunit d 2

ATP6V0D2 SNPs

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  1. RS183497284 (ATP6V0D2) ??

Top Gene-Substance Interactions

ATP6V0D2 Interacts with These Diseases

Disease Score

Substances That Increase ATP6V0D2

Substances Interaction Organism Category

Substances That Decrease ATP6V0D2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • c-Fos
  • Lmo2
  • Pax-5
  • Fra-1
  • JunD

Tissue specificity:

Kidney, osteoclast and lung.

Gene Pathways:

  • Metabolic pathways
  • Disease
  • Signal Transduction
  • Tuberculosis
  • Epithelial cell signaling in Helicobacter pylori infection
  • Lysosome
  • Phagosome
  • Rheumatoid arthritis
  • Transmembrane transport of small molecules
  • Collecting duct acid secretion
  • Oxidative phosphorylation

Molecular Function:

  • Hydrogen-Exporting Atpase Activity, Phosphorylative Mechanism
  • Proton-Transporting Atpase Activity, Rotational Mechanism
  • Hydrogen Ion Transmembrane Transporter Activity

Biological Processes:

  • Atp Hydrolysis Coupled Proton Transport
  • Insulin Receptor Signaling Pathway
  • Ion Transmembrane Transport
  • Phagosome Acidification
  • Regulation Of Macroautophagy
  • Transferrin Transport
  • Vacuolar Acidification
  • Vacuolar Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ATP6D2| ATP6V0D1| ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d| ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1| ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2| ATPase, H+ transporting, lysosomal V0 subunit D2| ATPase, H+ transporting, V0 subunit D| CB1_002519028| EGK_19094| H920_15980| I79_021466| M91_21434| M959_13801| MDA_GLEAN10003811| N300_07380| N305_10123| N307_04637| osteoclast-specific vacuolar ATP synthase| PAL_GLEAN10019439| PANDA_005086| TREES_T100010184| UY3_00443| vacuolar proton pump subunit d 2| vacuolar proton-translocating ATPase d subunit d2| V-ATPase| V-ATPase subunit d 2| VMA6| V-type proton ATPase subunit d 2| Y1Q_002614| atp6v0d2

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