The Function of ATP6V0D2
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis.
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Protein names
Recommended name:
V-type proton ATPase subunit d 2Alternative name(s):
V-ATPase subunit d 2Vacuolar proton pump subunit d 2
- RS183497284 (ATP6V0D2) ??
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Top Gene-Substance Interactions
ATP6V0D2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ATP6V0D2
| Substances | Interaction | Organism | Category |
Substances That Decrease ATP6V0D2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Kidney, osteoclast and lung.
Gene Pathways:
Molecular Function:
- Hydrogen-Exporting Atpase Activity, Phosphorylative Mechanism
- Proton-Transporting Atpase Activity, Rotational Mechanism
- Hydrogen Ion Transmembrane Transporter Activity
Biological Processes:
- Atp Hydrolysis Coupled Proton Transport
- Insulin Receptor Signaling Pathway
- Ion Transmembrane Transport
- Phagosome Acidification
- Regulation Of Macroautophagy
- Transferrin Transport
- Vacuolar Acidification
- Vacuolar Transport