The Function of ATP1A2
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
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Protein names
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-2Short name:
+Alternative name(s):
Na(+Sodium pump subunit alpha-2
- RS6688363 (ATP1A2) ??
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Top Gene-Substance Interactions
Substances That Increase ATP1A2
| Substances | Interaction | Organism | Category |
Substances That Decrease ATP1A2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Bile secretion
- Pancreatic secretion
- Aldosterone-regulated sodium reabsorption
- Gastric acid secretion
- Protein digestion and absorption
- Proximal tubule bicarbonate reclamation
- Transmembrane transport of small molecules
- Endocrine and other factor-regulated calcium reabsorption
- Mineral absorption
- Salivary secretion
- Cardiac muscle contraction
- Carbohydrate digestion and absorption
Molecular Function:
- Atp Binding
- Chaperone Binding
- Metal Ion Binding
- Sodium:Potassium-Exchanging Atpase Activity
- Steroid Hormone Binding
Biological Processes:
- Adult Locomotory Behavior
- Atp Hydrolysis Coupled Proton Transport
- Atp Metabolic Process
- Cardiac Muscle Contraction
- Cell Communication By Electrical Coupling Involved In Cardiac Conduction
- Cellular Potassium Ion Homeostasis
- Cellular Response To Mechanical Stimulus
- Cellular Response To Steroid Hormone Stimulus
- Cellular Sodium Ion Homeostasis
- Ion Transmembrane Transport
- Locomotion
- Membrane Depolarization During Cardiac Muscle Cell Action Potential
- Membrane Repolarization
- Negative Regulation Of Calcium:Sodium Antiporter Activity
- Negative Regulation Of Calcium Ion Transmembrane Transport
- Negative Regulation Of Cytosolic Calcium Ion Concentration
- Negative Regulation Of Heart Contraction
- Negative Regulation Of Striated Muscle Contraction
- Neurotransmitter Uptake
- Potassium Ion Import
- Potassium Ion Import Across Plasma Membrane
- Potassium Ion Transport
- Regulation Of Blood Pressure
- Regulation Of Cardiac Conduction
- Regulation Of Cardiac Muscle Cell Contraction
- Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
- Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse
- Regulation Of Respiratory Gaseous Exchange By Neurological System Process
- Regulation Of Smooth Muscle Contraction
- Regulation Of Striated Muscle Contraction
- Regulation Of Synaptic Transmission, Glutamatergic
- Regulation Of The Force Of Heart Contraction
- Regulation Of Vasoconstriction
- Relaxation Of Cardiac Muscle
- Response To Glycoside
- Response To Nicotine
- Sodium Ion Export From Cell
- Sodium Ion Transport
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