The Function of ATP1A2
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
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Protein names
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-2Short name:
+Alternative name(s):
Na(+Sodium pump subunit alpha-2
- RS6688363 (ATP1A2) ??
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Top Gene-Substance Interactions
Substances That Increase ATP1A2
| Substances | Interaction | Organism | Category |
Substances That Decrease ATP1A2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Bile secretion
- Pancreatic secretion
- Aldosterone-regulated sodium reabsorption
- Gastric acid secretion
- Protein digestion and absorption
- Proximal tubule bicarbonate reclamation
- Transmembrane transport of small molecules
- Endocrine and other factor-regulated calcium reabsorption
- Mineral absorption
- Salivary secretion
- Cardiac muscle contraction
- Carbohydrate digestion and absorption
Molecular Function:
- Sodium:Potassium-Exchanging Atpase Activity
- Atp Binding
- Metal Ion Binding
- Chaperone Binding
- Steroid Hormone Binding
Biological Processes:
- Neurotransmitter Uptake
- Regulation Of The Force Of Heart Contraction
- Regulation Of Respiratory Gaseous Exchange By Neurological System Process
- Potassium Ion Transport
- Sodium Ion Transport
- Cellular Sodium Ion Homeostasis
- Regulation Of Smooth Muscle Contraction
- Regulation Of Striated Muscle Contraction
- Regulation Of Blood Pressure
- Adult Locomotory Behavior
- Visual Learning
- Potassium Ion Import
- Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
- Atp Hydrolysis Coupled Proton Transport
- Regulation Of Vasoconstriction
- Cellular Potassium Ion Homeostasis
- Ion Transmembrane Transport
- Response To Nicotine
- Sodium Ion Export From Cell
- Locomotion
- Negative Regulation Of Heart Contraction
- Negative Regulation Of Striated Muscle Contraction
- Atp Metabolic Process
- Negative Regulation Of Cytosolic Calcium Ion Concentration
- Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse
- Regulation Of Synaptic Transmission, Glutamatergic
- Relaxation Of Cardiac Muscle
- Cardiac Muscle Contraction
- Cellular Response To Mechanical Stimulus
- Cellular Response To Steroid Hormone Stimulus
- Regulation Of Cardiac Muscle Cell Contraction
- Membrane Repolarization
- Membrane Depolarization During Cardiac Muscle Cell Action Potential
- Cell Communication By Electrical Coupling Involved In Cardiac Conduction
- Negative Regulation Of Calcium Ion Transmembrane Transport
- Negative Regulation Of Calcium:Sodium Antiporter Activity
- Response To Glycoside
- Regulation Of Cardiac Conduction
- Potassium Ion Import Across Plasma Membrane