The Function of ATG5
May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
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Protein names
Recommended name:
Autophagy protein 5Alternative name(s):
APG5-likeApoptosis-specific protein
- RS3827644 (ATG5) ??
- RS484621 (ATG5) ??
- RS548234 (ATG5) ??
- RS573775 (ATG5) ??
- RS6568431 (ATG5) ??
- RS742108 (ATG5) ??
- RS9372120 (ATG5) ??
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Top Gene-Substance Interactions
ATG5 Interacts with These Diseases
| Disease | Score |
Substances That Increase ATG5
| Substances | Interaction | Organism | Category |
Substances That Decrease ATG5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Gene Pathways:
Induction:
By apoptotic stimuli.
Biological Processes:
- Aggrephagy
- Apoptotic Process
- Autophagosome Assembly
- Autophagy
- Cellular Response To Nitrogen Starvation
- C-Terminal Protein Lipidation
- Innate Immune Response
- Macroautophagy
- Mitophagy
- Negative Regulation Of Cell Death
- Nucleophagy
- Post-Translational Protein Modification
- Regulation Of Cilium Assembly
- Antigen Processing And Presentation Of Endogenous Antigen
- Blood Vessel Remodeling
- Cellular Homeostasis
- Heart Contraction
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Histone H4-K16 Acetylation
- Negative Regulation Of Protein Ubiquitination
- Negative Regulation Of Reactive Oxygen Species Metabolic Process
- Negative Stranded Viral Rna Replication
- Negative Thymic T Cell Selection
- Otolith Development
- Positive Regulation Of Mitophagy
- Positive Regulation Of Mucus Secretion
- Protein Lipidation Involved In Autophagosome Assembly
- Regulation Of Cytokine Secretion Involved In Immune Response
- Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
- Response To Fungus
- Vasodilation
- Ventricular Cardiac Muscle Cell Development