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  3. ATG5

ATG5 (Autophagy related 5)

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The Function of ATG5

May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.

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Protein names

Recommended name:

Autophagy protein 5

Alternative name(s):

APG5-like
Apoptosis-specific protein

ATG5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3827644 (ATG5) ??
  2. RS484621 (ATG5) ??
  3. RS548234 (ATG5) ??
  4. RS573775 (ATG5) ??
  5. RS6568431 (ATG5) ??
  6. RS742108 (ATG5) ??
  7. RS9372120 (ATG5) ??

Top Gene-Substance Interactions

ATG5 Interacts with These Diseases

Disease Score

Substances That Increase ATG5

Substances Interaction Organism Category

Substances That Decrease ATG5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.

Gene Pathways:

  • Immune System
  • Regulation of autophagy
  • RIG-I-like receptor signaling pathway
  • Innate Immune System
  • Shigellosis

Induction:

By apoptotic stimuli.

Biological Processes:

  • Aggrephagy
  • Apoptotic Process
  • Autophagosome Assembly
  • Autophagy
  • Cellular Response To Nitrogen Starvation
  • C-Terminal Protein Lipidation
  • Innate Immune Response
  • Macroautophagy
  • Mitophagy
  • Negative Regulation Of Cell Death
  • Nucleophagy
  • Post-Translational Protein Modification
  • Regulation Of Cilium Assembly
  • Antigen Processing And Presentation Of Endogenous Antigen
  • Blood Vessel Remodeling
  • Cellular Homeostasis
  • Heart Contraction
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Histone H4-K16 Acetylation
  • Negative Regulation Of Protein Ubiquitination
  • Negative Regulation Of Reactive Oxygen Species Metabolic Process
  • Negative Stranded Viral Rna Replication
  • Negative Thymic T Cell Selection
  • Otolith Development
  • Positive Regulation Of Mitophagy
  • Positive Regulation Of Mucus Secretion
  • Protein Lipidation Involved In Autophagosome Assembly
  • Regulation Of Cytokine Secretion Involved In Immune Response
  • Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
  • Response To Fungus
  • Vasodilation
  • Ventricular Cardiac Muscle Cell Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ASP| Anapl_18075| APG5| Apg5l| APG5-LIKE| apoptosis-specific protein| AS28_13922| ATG5 autophagy related 5 homolog| ATG5 autophagy related 5 homolog (S. cerevisiae)| Atg5l| Atg5-PA| autophagy 5-like| autophagy 5-like protein| Autophagy protein 5| autophagy protein 5-like protein| Autophagy-related 5| Autophagy-specific gene 5| C88337| CG1643 gene product from transcript CG1643-RA| CG1643-PA| D623_10034694| DmAtg5| Dmel_CG1643| EGK_15205| GW7_16556| H920_16293| hAPG5| I79_015053| M959_02129| N300_06996| N301_01650| N302_02733| N303_13524| N306_03933| N307_01061| N309_13253| N310_12405| N312_11508| N320_12213| N321_03425| N328_07394| N329_02712| N330_02446| N331_10548| N333_12510| N334_12450| N336_12012| N339_04760| N340_06521| N341_12171| Paddy| PAL_GLEAN10018553| PANDA_015048| TREES_T100016222| UY3_13904| Y1Q_005272| Y956_01673| Z169_00103| atg5

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