The Function of ATF6
Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Protein names
Recommended name:
Cyclic AMP-dependent transcription factor ATF-6 alphaAlternative name(s):
cAMP-dependent transcription factor ATF-6 alphaActivating transcription factor 6 alpha
ATF6-alpha
- RS10918270 (ATF6) ??
- RS2070150 (ATF6) ??
- RS2340727 (ATF6) ??
- RS2499846 (ATF6) ??
- RS3767633 (ATF6) ??
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Top Gene-Substance Interactions
ATF6 Interacts with These Diseases
Disease | Score |
Substances That Increase ATF6
Substances | Interaction | Organism | Category |
Substances That Decrease ATF6
Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Achromatopsia 7From UniProt: Achromatopsia 7 (ACHM7): A form of achromatopsia, an ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus. [MIM:616517]
From NCBI Gene: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] From UniProt: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Gene Pathways:
Molecular Function:
- Camp Response Element Binding
- Protein Heterodimerization Activity
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Transcription Coactivator Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Regulatory Region Sequence-Specific Dna Binding
- Identical Protein Binding
Biological Processes:
- Atf6-Mediated Unfolded Protein Response
- Endoplasmic Reticulum Unfolded Protein Response
- Eye Development
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Endoplasmic Reticulum Stress
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Unfolded Protein Response
- Protein Folding
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Response To Stress
- Signal Transduction
- Transcription, Dna-Templated
- Visual Perception