The Function of ATF3
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
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Protein names
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3Alternative name(s):
cAMP-dependent transcription factor ATF-3Activating transcription factor 3
- RS188145713 (ATF3) ??
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Top Gene-Substance Interactions
ATF3 Interacts with These Diseases
| Disease | Score |
Substances That Increase ATF3
| Substances | Interaction | Organism | Category |
Substances That Decrease ATF3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transcription Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Corepressor Activity
- Identical Protein Binding
- Protein Homodimerization Activity
- Transcription Regulatory Region Dna Binding
- Protein Heterodimerization Activity
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Gluconeogenesis
- Positive Regulation Of Cell Proliferation
- Cellular Response To Amino Acid Starvation
- Skeletal Muscle Cell Differentiation
- Perk-Mediated Unfolded Protein Response
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Arsenic-Containing Substance
- Negative Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Trail-Activated Apoptotic Signaling Pathway
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Endoplasmic Reticulum Stress