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  3. ATF3

ATF3 (Activating transcription factor 3)

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The Function of ATF3

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

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Protein names

Recommended name:

Cyclic AMP-dependent transcription factor ATF-3

Alternative name(s):

cAMP-dependent transcription factor ATF-3
Activating transcription factor 3

ATF3 SNPs

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  1. RS188145713 (ATF3) ??

Top Gene-Substance Interactions

ATF3 Interacts with These Diseases

Disease Score

Substances That Increase ATF3

Substances Interaction Organism Category

Substances That Decrease ATF3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Egr-1
  • CREB
  • deltaCREB
  • C/EBPbeta
  • C/EBPalpha
  • c-Fos

Gene Pathways:

  • Metabolism of proteins

Molecular Function:

  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Regulatory Region Dna Binding
  • Transcription Regulatory Region Sequence-Specific Dna Binding
  • Identical Protein Binding

Biological Processes:

  • Cellular Response To Amino Acid Starvation
  • Gluconeogenesis
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Perk-Mediated Unfolded Protein Response
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Trail-Activated Apoptotic Signaling Pathway
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Endoplasmic Reticulum Stress
  • Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Arsenic-Containing Substance
  • Skeletal Muscle Cell Differentiation

Drug Bank:

  • Pseudoephedrine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| transcription factor protein| A3-3| Anapl_06851| AS27_04698| AS28_07619| atf-3| Atf3-PA| Atf3-PB| Atf3-PC| cAMP-dependent transcription factor ATF-3| CB1_002060003| CG11405 gene product from transcript CG11405-RC| CG11405-PA| CG11405-PB| CG11405-PC| cyclic AMP-dependent transcription factor ATF-3| D623_10018256| dATF3| DM11| Dmel_CG11405| EG:33C11.1| EGK_01674| H920_13191| liver regeneration factor 1| LRF-1| LRFI| LRG-21| M959_04477| MDA_GLEAN10017446| N300_11437| N301_08621| N302_00710| N303_07610| N305_00996| N306_11618| N307_14766| N308_02448| N309_09138| N310_12796| N311_10649| N312_02497| N320_09394| N321_03987| N322_00933| N324_09959| N325_11420| N326_01529| N327_07870| N328_09335| N329_11102| N330_06859| N331_09788| N332_08612| N334_07571| N335_12305| N336_10746| N340_05787| N341_02883| PAL_GLEAN10017626| PANDA_005437| transcription factor LRG-21| TREES_T100004682| UY3_05341| Y1Q_002570| Y956_07734| Z169_07522| atf3

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