The Function of AS3MT
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.
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Protein names
Recommended name:
Arsenite methyltransferaseAlternative name(s):
Methylarsonite methyltransferaseS-adenosyl-L-methionine:arsenic(III
- RS11191439 (AS3MT) ??
- RS11191454 (AS3MT) ??
- RS3740393 (AS3MT) ??
- RS7897654 (AS3MT) ??
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Top Gene-Substance Interactions
AS3MT Interacts with These Diseases
| Disease | Score |
Substances That Increase AS3MT
| Substances | Interaction | Organism | Category |
Substances That Decrease AS3MT
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Arsenite Methyltransferase Activity
- Methylarsonite Methyltransferase Activity
- S-Adenosylmethionine-Dependent Methyltransferase Activity