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  3. AS3MT

AS3MT (Arsenite methyltransferase)

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The Function of AS3MT

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.

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Protein names

Recommended name:

Arsenite methyltransferase

Alternative name(s):

Methylarsonite methyltransferase
S-adenosyl-L-methionine:arsenic(III

AS3MT SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11191439 (AS3MT) ??
  2. RS11191454 (AS3MT) ??
  3. RS3740393 (AS3MT) ??
  4. RS7897654 (AS3MT) ??

Top Gene-Substance Interactions

AS3MT Interacts with These Diseases

Disease Score

Substances That Increase AS3MT

Substances Interaction Organism Category

Substances That Decrease AS3MT

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO4
  • C/EBPbeta
  • C/EBPalpha
  • Sp1
  • FOXO1a
  • FOXO1
  • Cdc5

Molecular Function:

  • Arsenite Methyltransferase Activity
  • Methylarsonite Methyltransferase Activity
  • S-Adenosylmethionine-Dependent Methyltransferase Activity

Biological Processes:

  • Arsonoacetate Metabolic Process
  • Methylation
  • Toxin Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07323| arsenic (+3 oxidation state) methyltransferase| arsenic methyltransferase| AS27_02722| AS28_07173| CYT19| M91_06639| M959_09999| methylarsonite methyltransferase| methyltransferase cyt19| N300_12476| N301_06999| N302_13604| N303_14221| N305_05553| N306_03373| N307_08796| N309_09983| N310_05946| N311_08943| N312_08321| N320_07014| N321_06631| N322_08786| N324_00804| N325_05907| N327_07521| N328_06658| N330_07589| N331_00432| N332_00381| N333_08067| N334_06481| N335_11160| N339_08434| N340_11244| N341_09627| PANDA_001787| S-adenosyl-L-methionine:arsenic(III) methyltransferase| S-adenosylmethionine:arsenic (III) methyltransferase| TREES_T100016514| UPF0693 protein C10orf32| Y956_01318| Z169_01726| as3mt

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