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  3. ARRDC3

ARRDC3 (Arrestin domain containing 3)

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The Function of ARRDC3

Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550).

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Protein names

Recommended name:

Arrestin domain-containing protein 3

Short name:

TLIMP

Alternative name(s):

TBP-2-like inducible membrane protein

Top Gene-Substance Interactions

Substances That Increase ARRDC3

Substances Interaction Organism Category

Substances That Decrease ARRDC3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Nkx2-5
  • C/EBPbeta
  • Hlf
  • IRF-2
  • Nkx5-1

Tissue specificity:

Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow (PubMed:16269462). Strong expression in differentiated adipocytes compared to preadipocytes (PubMed:16269462). Detected in omental fat and subcutaneous fat tissue (PubMed:21982743).

Induction:

By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (a PPARD ligand), by vitamin D3 and, to a lesser extent, by phorbol myristate acetate (PMA) in the promyelocytic leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist) (PubMed:16269462). Up-regulated by fasting (PubMed:21982743).

Molecular Function:

  • Beta-3 Adrenergic Receptor Binding

Biological Processes:

  • Fat Pad Development
  • Negative Regulation Of Heat Generation
  • Negative Regulation Of Locomotion Involved In Locomotory Behavior
  • Negative Regulation Of Multicellular Organismal Metabolic Process
  • Positive Regulation Of Adrenergic Receptor Signaling Pathway
  • Positive Regulation Of Ubiquitin-Protein Transferase Activity
  • Signal Transduction
  • Skin Development
  • Temperature Homeostasis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| alpha-arrestin 3| Anapl_17687| arrestin domain-containing protein 2| Arrestin domain-containing protein 3| AS27_10267| AS28_03999| CB1_001052030| EGK_16688| GW7_00113| H920_10814| I79_016407| liver regeneration-related protein LRRG00048| LRRGT00048| M959_14414| N300_13711| N301_05737| N302_05469| N303_04832| N305_03980| N306_15388| N307_05002| N308_04879| N309_03630| N310_02316| N312_04583| N320_11958| N321_00976| N322_10383| N324_04531| N326_03579| N327_12828| N328_02847| N329_06552| N330_11113| N331_11207| N332_06672| N333_08170| N334_02405| N335_05495| N336_00135| N339_08993| N340_01203| PAL_GLEAN10024971| PANDA_001472| TBP-2-like inducible membrane protein| TLIMP| TREES_T100012164| UY3_01581| Y1Q_008948| Y956_03003| Z169_10518| arrdc3

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