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  3. ARNT

ARNT (Aryl hydrocarbon receptor nuclear translocator)

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The Function of ARNT

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

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Protein names

Recommended name:

Aryl hydrocarbon receptor nuclear translocator

Alternative name(s):

ARNT protein
Class E basic helix-loop-helix protein 2
bHLHe2
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta
HIF-1-beta
HIF1-beta

ARNT SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2134688 (ARNT) ??
  2. RS2228099 (ARNT) ??
  3. RS7517566 (ARNT) ??

Top Gene-Substance Interactions

ARNT Interacts with These Diseases

Disease Score

Substances That Increase ARNT

Substances Interaction Organism Category

Substances That Decrease ARNT

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • Max
  • c-Jun
  • C/EBPalpha
  • NF-1
  • GATA-3

Gene Pathways:

  • Pathways in cancer
  • Cellular responses to stress
  • Renal cell carcinoma

Molecular Function:

  • Aryl Hydrocarbon Receptor Activity
  • Aryl Hydrocarbon Receptor Binding
  • Enhancer Binding
  • Protein Heterodimerization Activity
  • Transcription Coactivator Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding

Biological Processes:

  • Cell Differentiation
  • Embryonic Placenta Development
  • Mrna Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Erythrocyte Differentiation
  • Positive Regulation Of Glycolytic Process
  • Positive Regulation Of Hormone Biosynthetic Process
  • Positive Regulation Of Protein Sumoylation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Vascular Endothelial Growth Factor Production
  • Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
  • Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Hypoxia
  • Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Oxidative Stress
  • Response To Hypoxia
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| transcription factor protein| AHA-1| arnt1| arnt 1| ARNT protein| ARNT_tv3| aryl hydrocarbon receptor nuclear translocater| Aryl hydrocarbon receptor nuclear translocator 1| aryl hydrocarbon receptor nuclear translocator homolog| aryl hydrocarbon receptor nuclear translocator isoformX2| Aryl hydrocarbon receptor nuclear translocator-like protein| AS27_07615| AS28_14122| bHLHe2| cathepsin K| class E basic helix-loop-helix protein 2| CTSK| D3Ertd557e| dioxin receptor, nuclear translocator| Drnt| ESTM42| HIF1B| HIF-1beta| HIF-1-beta| HIF1-beta| HIF1BETA| hypoxia-inducible factor 1-beta| hypoxia-inducible factor 1, beta subunit| M959_14876| MDA_GLEAN10009665| N300_10906| N301_06023| N302_14933| N303_12375| N305_14617| N306_07281| N308_16163| N312_08235| N321_04534| N322_11291| N324_08439| N325_08013| N326_06937| N327_08484| N328_07591| N330_06138| N331_05963| N333_04635| N334_05362| N335_01009| N336_00423| N339_02583| N340_00704| N341_06724| rtARNT| TANGO| W08714| xArnt| Y1Q_019341| Y956_08221| Z169_10548| arnt

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