The Function of ARNT
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
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Protein names
Recommended name:
Aryl hydrocarbon receptor nuclear translocatorAlternative name(s):
ARNT proteinClass E basic helix-loop-helix protein 2
bHLHe2
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta
HIF-1-beta
HIF1-beta
- RS2134688 (ARNT) ??
- RS2228099 (ARNT) ??
- RS7517566 (ARNT) ??
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Top Gene-Substance Interactions
ARNT Interacts with These Diseases
| Disease | Score |
Substances That Increase ARNT
| Substances | Interaction | Organism | Category |
Substances That Decrease ARNT
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Coactivator Activity
- Aryl Hydrocarbon Receptor Activity
- Transcription Factor Binding
- Aryl Hydrocarbon Receptor Binding
- Enhancer Binding
- Protein Heterodimerization Activity
Biological Processes:
- Response To Hypoxia
- Embryonic Placenta Development
- Positive Regulation Of Endothelial Cell Proliferation
- Transcription, Dna-Templated
- Positive Regulation Of Vascular Endothelial Growth Factor Production
- Cell Differentiation
- Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Protein Sumoylation
- Mrna Transcription From Rna Polymerase Ii Promoter
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Oxidative Stress
- Positive Regulation Of Erythrocyte Differentiation
- Positive Regulation Of Glycolytic Process
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Hormone Biosynthetic Process
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Hypoxia