The Function of ARID2
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.
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Protein names
Recommended name:
AT-rich interactive domain-containing protein 2Short name:
BAF200Alternative name(s):
ARID domain-containing protein 2BRG1-associated factor 200
Zinc finger protein with activation potential
Zipzap/p200
- RS247929 (ARID2) ??
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Top Gene-Substance Interactions
Substances That Increase ARID2
| Substances | Interaction | Organism | Category |
Substances That Decrease ARID2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in heart and testis.
Gene Pathways:
Developmental stage:
Up-regulated in adult heart (at protein level).
Molecular Function:
Biological Processes:
- Nucleosome Disassembly
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Cell Proliferation
- Covalent Chromatin Modification
- Negative Regulation Of Cell Migration