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  3. ARC

ARC (Activity regulated cytoskeleton associated protein)

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The Function of ARC

Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.

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Protein names

Recommended name:

Nucleolar protein 3

Alternative name(s):

Apoptosis repressor with CARD
Muscle-enriched cytoplasmic protein
Myp
Nucleolar protein of 30 kDa
Nop30

ARC SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7465272 (ARC) ??

Top Gene-Substance Interactions

ARC Interacts with These Diseases

Disease Score

Substances That Increase ARC

Substances Interaction Organism Category

Substances That Decrease ARC

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • c-Fos

Molecular Function:

  • Calcium Ion Binding
  • Caspase Binding
  • Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
  • Rna Binding

Biological Processes:

  • Anterior/Posterior Pattern Specification
  • Cytoskeleton Organization
  • Endocytosis
  • Endoderm Development
  • Learning
  • Positive Regulation Of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Selective Glutamate Receptor Activity
  • Regulation Of Cell Morphogenesis
  • Regulation Of Neuronal Synaptic Plasticity
  • Blood Vessel Remodeling
  • Cardiac Muscle Cell Apoptotic Process
  • Inhibition Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Intrinsic Apoptotic Signaling Pathway
  • Mrna Splice Site Selection
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
  • Negative Regulation Of Muscle Atrophy
  • Negative Regulation Of Necrotic Cell Death
  • Negative Regulation Of Oxidative Stress-Induced Intrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Release Of Cytochrome C From Mitochondria
  • Negative Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
  • Protein Oligomerization
  • Regulation Of Nf-Kappab Import Into Nucleus
  • Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
  • Response To Hypoxia
  • Response To Injury Involved In Regulation Of Muscle Adaptation
  • Response To Ischemia
  • Rna Splicing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| activity regulated cytoskeletal-associated protein| activity-regulated cytoskeleton-associated-like protein| activity-regulated cytoskeleton-associated protein| activity-regulated gene 3.1 protein| activity-regulated gene 3.1 protein homolog| Anapl_14808| Arc3.1| ARC/ARG3.1| Arg3.1| AS27_07169| AS28_06140| C86064| CB1_000514002| HEAT repeat-containing protein 7A| M959_15096| mArc| N300_08102| N301_09776| N303_13866| N305_02786| N306_10950| N307_10611| N308_05852| N309_12139| N310_03929| N311_11747| N312_09560| N320_01741| N321_14351| N322_01680| N324_07062| N325_03510| N326_02904| N327_01236| N328_02884| N329_01523| N330_09738| N331_12180| N332_04939| N333_02373| N334_13968| N335_10922| N336_03756| N339_07630| N340_12453| N341_07090| PAL_GLEAN10010416| rg3.1| Y1Q_006451| Y956_13279| Z169_11663| arc

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