The Function of ARC
Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
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Protein names
Recommended name:
Nucleolar protein 3Alternative name(s):
Apoptosis repressor with CARDMuscle-enriched cytoplasmic protein
Myp
Nucleolar protein of 30 kDa
Nop30
- RS7465272 (ARC) ??
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Top Gene-Substance Interactions
ARC Interacts with These Diseases
| Disease | Score |
Substances That Increase ARC
| Substances | Interaction | Organism | Category |
Substances That Decrease ARC
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Rna Binding
- Calcium Ion Binding
- Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
- Caspase Binding
Biological Processes:
- Response To Hypoxia
- Blood Vessel Remodeling
- Response To Ischemia
- Mrna Splice Site Selection
- Endocytosis
- Cytoskeleton Organization
- Endoderm Development
- Learning
- Rna Splicing
- Anterior/Posterior Pattern Specification
- Cardiac Muscle Cell Apoptotic Process
- Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
- Negative Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
- Negative Regulation Of Muscle Atrophy
- Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
- Response To Injury Involved In Regulation Of Muscle Adaptation
- Regulation Of Cell Morphogenesis
- Regulation Of Nf-Kappab Import Into Nucleus
- Negative Regulation Of Apoptotic Process
- Regulation Of Neuronal Synaptic Plasticity
- Protein Oligomerization
- Negative Regulation Of Necrotic Cell Death
- Negative Regulation Of Release Of Cytochrome C From Mitochondria
- Intrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
- Negative Regulation Of Oxidative Stress-Induced Intrinsic Apoptotic Signaling Pathway
- Inhibition Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Positive Regulation Of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Selective Glutamate Receptor Activity
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway