The Function of AQP9
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.
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Protein names
Recommended name:
Aquaporin-9Short name:
AQP-9Alternative name(s):
Aquaglyceroporin-9Small solute channel 1
- RS16939881 (AQP9) ??
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Top Gene-Substance Interactions
AQP9 Interacts with These Diseases
| Disease | Score |
Substances That Increase AQP9
| Substances | Interaction | Organism | Category |
Substances That Decrease AQP9
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.
Gene Pathways:
Molecular Function:
- Amine Transmembrane Transporter Activity
- Purine Nucleobase Transmembrane Transporter Activity
- Pyrimidine Nucleobase Transmembrane Transporter Activity
- Water Transmembrane Transporter Activity
- Polyol Transmembrane Transporter Activity
- Urea Transmembrane Transporter Activity
- Water Channel Activity
- Glycerol Channel Activity
- Urea Channel Activity
- Porin Activity
- Carboxylic Acid Transmembrane Transporter Activity
Biological Processes:
- Transport
- Water Transport
- Purine Nucleobase Transport
- Immune Response
- Response To Osmotic Stress
- Excretion
- Metabolic Process
- Cellular Water Homeostasis
- Response To Organic Substance
- Canalicular Bile Acid Transport
- Polyol Transport
- Glycerol Transport
- Amine Transport
- Pyrimidine Nucleobase Transport
- Water Homeostasis
- Response To Mercury Ion
- Carboxylic Acid Transport
- Cellular Response To Camp
- Urea Transmembrane Transport