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  3. AQP9

AQP9 (Aquaporin 9)

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The Function of AQP9

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.

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Protein names

Recommended name:

Aquaporin-9

Short name:

AQP-9

Alternative name(s):

Aquaglyceroporin-9
Small solute channel 1

AQP9 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS16939881 (AQP9) ??

Top Gene-Substance Interactions

AQP9 Interacts with These Diseases

Disease Score

Substances That Increase AQP9

Substances Interaction Organism Category

Substances That Decrease AQP9

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • HNF-1A
  • HNF-1
  • C/EBPalpha
  • Hlf

Tissue specificity:

Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.

Gene Pathways:

  • Bile secretion
  • Transmembrane transport of small molecules

Molecular Function:

  • Amine Transmembrane Transporter Activity
  • Carboxylic Acid Transmembrane Transporter Activity
  • Glycerol Channel Activity
  • Polyol Transmembrane Transporter Activity
  • Porin Activity
  • Purine Nucleobase Transmembrane Transporter Activity
  • Pyrimidine Nucleobase Transmembrane Transporter Activity
  • Urea Channel Activity
  • Urea Transmembrane Transporter Activity
  • Water Channel Activity
  • Water Transmembrane Transporter Activity

Biological Processes:

  • Amine Transport
  • Canalicular Bile Acid Transport
  • Carboxylic Acid Transport
  • Cellular Response To Camp
  • Cellular Water Homeostasis
  • Excretion
  • Glycerol Transport
  • Immune Response
  • Metabolic Process
  • Polyol Transport
  • Purine Nucleobase Transport
  • Pyrimidine Nucleobase Transport
  • Response To Mercury Ion
  • Response To Organic Substance
  • Response To Osmotic Stress
  • Transport
  • Urea Transmembrane Transport
  • Water Homeostasis
  • Water Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| aqp9| A306_10891| AQP-9| aquaglyceroporin-9| Aquaporin-9| AS27_14913| AS28_04213| CB1_000567010| D623_10007065| EGK_17529| H920_12606| HsT17287| M959_05265| MDA_GLEAN10012032| membrane water channel| N300_11935| N301_08224| N302_04906| N305_08054| N306_09272| N307_06517| N308_02774| N309_04869| N310_09452| N311_08232| N312_09129| N320_01018| N321_13170| N322_00073| N324_01287| N325_01793| N326_06232| N327_11002| N329_08928| N330_07701| N331_00050| N332_04105| N333_00380| N335_11740| N336_09550| N339_12095| N340_03524| N341_07023| neutral solute channel aquaporin 9| PAL_GLEAN10023432| PANDA_009483| small solute channel 1| SSC1| T17287| TREES_T100000157| UY3_03820| Y1Q_003204| Y956_05563| Z169_06655

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