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  3. APOC2

APOC2 (Apolipoprotein C2)

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The Function of APOC2

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

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Protein names

Recommended name:

Apolipoprotein C-II

Alternative name(s):

Apo-CII
ApoC-II
Apolipoprotein C2
ProapoC-II

Top Gene-Substance Interactions

APOC2 Interacts with These Diseases

Disease Score

Substances That Increase APOC2

Substances Interaction Organism Category

Substances That Decrease APOC2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • SREBP-1a
  • Lmo2
  • Olf-1
  • YY1
  • SREBP-1c
  • SREBP-1b
  • AREB6
  • HNF-3beta
  • Msx-1

Tissue specificity:

Liver and intestine.

Gene Pathways:

  • Metabolism
  • Disease
  • Signal Transduction

Molecular Function:

  • Lipase Inhibitor Activity
  • Lipid Binding
  • Lipoprotein Lipase Activator Activity
  • Phospholipase Activator Activity
  • Phospholipase Binding
  • Protein Homodimerization Activity

Biological Processes:

  • Cholesterol Efflux
  • Cholesterol Homeostasis
  • Chylomicron Remnant Clearance
  • Chylomicron Remodeling
  • High-Density Lipoprotein Particle Clearance
  • Lipid Catabolic Process
  • Lipoprotein Metabolic Process
  • Negative Regulation Of Cholesterol Transport
  • Negative Regulation Of Lipid Metabolic Process
  • Negative Regulation Of Receptor-Mediated Endocytosis
  • Negative Regulation Of Very-Low-Density Lipoprotein Particle Clearance
  • Phospholipid Efflux
  • Positive Regulation Of Fatty Acid Biosynthetic Process
  • Positive Regulation Of Lipoprotein Lipase Activity
  • Positive Regulation Of Phospholipase Activity
  • Positive Regulation Of Phospholipid Catabolic Process
  • Positive Regulation Of Triglyceride Catabolic Process
  • Positive Regulation Of Very-Low-Density Lipoprotein Particle Remodeling
  • Retinoid Metabolic Process
  • Reverse Cholesterol Transport
  • Triglyceride Homeostasis
  • Triglyceride-Rich Lipoprotein Particle Remodeling
  • Very-Low-Density Lipoprotein Particle Remodeling
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| APOC4| ApoC-II| APOCII| APO-CII| apolipoprotein CII| apolipoprotein C-II| apolipoprotein C-II-like protein| apolipoprotein C-IV| D623_10006035| fb71a04| fb98g08| GW7_18157| H920_04940| MDA_GLEAN10005802| PANDA_013607| putative apolipoprotein C2| RGD1560725| TREES_T100011512| apoc2

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