The Function of APOC2
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.
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Protein names
Recommended name:
Apolipoprotein C-IIAlternative name(s):
Apo-CIIApoC-II
Apolipoprotein C2
ProapoC-II
Top Gene-Substance Interactions
APOC2 Interacts with These Diseases
| Disease | Score |
Substances That Increase APOC2
| Substances | Interaction | Organism | Category |
Substances That Decrease APOC2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver and intestine.
Gene Pathways:
Molecular Function:
- Lipase Inhibitor Activity
- Lipid Binding
- Lipoprotein Lipase Activator Activity
- Phospholipase Activator Activity
- Phospholipase Binding
- Protein Homodimerization Activity
Biological Processes:
- Cholesterol Efflux
- Cholesterol Homeostasis
- Chylomicron Remnant Clearance
- Chylomicron Remodeling
- High-Density Lipoprotein Particle Clearance
- Lipid Catabolic Process
- Lipoprotein Metabolic Process
- Negative Regulation Of Cholesterol Transport
- Negative Regulation Of Lipid Metabolic Process
- Negative Regulation Of Receptor-Mediated Endocytosis
- Negative Regulation Of Very-Low-Density Lipoprotein Particle Clearance
- Phospholipid Efflux
- Positive Regulation Of Fatty Acid Biosynthetic Process
- Positive Regulation Of Lipoprotein Lipase Activity
- Positive Regulation Of Phospholipase Activity
- Positive Regulation Of Phospholipid Catabolic Process
- Positive Regulation Of Triglyceride Catabolic Process
- Positive Regulation Of Very-Low-Density Lipoprotein Particle Remodeling
- Retinoid Metabolic Process
- Reverse Cholesterol Transport
- Triglyceride Homeostasis
- Triglyceride-Rich Lipoprotein Particle Remodeling
- Very-Low-Density Lipoprotein Particle Remodeling