The Function of APOBEC3B

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

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Protein names

Recommended name:

DNA dC->dU-editing enzyme APOBEC-3B

Short name:

A3B

Alternative name(s):

Phorbolin-1-related protein
Phorbolin-2/3

Top Gene-Substance Interactions

APOBEC3B Interacts with These Diseases

Substances That Increase APOBEC3B

Substances That Decrease APOBEC3B

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical