• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. APOBEC3B

APOBEC3B (Apolipoprotein B mRNA editing enzyme catalytic subunit 3B)

Loading...

The Function of APOBEC3B

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

DNA dC->dU-editing enzyme APOBEC-3B

Short name:

A3B

Alternative name(s):

Phorbolin-1-related protein
Phorbolin-2/3

Top Gene-Substance Interactions

APOBEC3B Interacts with These Diseases

Disease Score

Substances That Increase APOBEC3B

Substances Interaction Organism Category

Substances That Decrease APOBEC3B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • USF1
  • LCR-F1
  • USF-1

Tissue specificity:

Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues.

Induction:

Phorbol 12-myristate 13-acetate (PMA) induces overexpression in keratinocytes. Up-regulated by IFN-alpha.

Molecular Function:

  • Deoxycytidine Deaminase Activity
  • Poly(A) Rna Binding
  • Zinc Ion Binding

Biological Processes:

  • Defense Response To Virus
  • Innate Immune Response
  • Negative Regulation Of Transposition
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

A3B| APOBEC1L| Apobec3| Apobec3f| apolipoprotein B editing complex 3| apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B| apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D| apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F| ARCD3| ARP4| bK150C2.2| cytidine deaminase| DJ742C19.2| DNA dC->dU-editing enzyme APOBEC3| DNA dC->dU-editing enzyme APOBEC-3B| phorbolin-1-related protein| phorbolin 2| phorbolin-2/3| phorbolin 3| PHRBNL| probable DNA dC->dU-editing enzyme APOBEC3| probable DNA dC->dU-editing enzyme APOBEC-3B| putative DNA dC->dU-editing enzyme APOBEC3| apobec3b

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved