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  3. APOA4

APOA4 (Apolipoprotein A4)

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The Function of APOA4

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

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Protein names

Recommended name:

Apolipoprotein A-IV

Alternative name(s):

Apo-AIV
ApoA-IV
Apolipoprotein A4

APOA4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1263173 (APOA4) ??
  2. RS5092 (APOA4) ??
  3. RS5104 (APOA4) ??
  4. RS5110 (APOA4) ??
  5. RS662799 (APOA4) ??
  6. RS7396835 (APOA4) ??

Top Gene-Substance Interactions

APOA4 Interacts with These Diseases

Disease Score

Substances That Increase APOA4

Substances Interaction Organism Category

Substances That Decrease APOA4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Synthesized primarily in the intestine and secreted in plasma.

Gene Pathways:

  • Fat digestion and absorption
  • Vitamin digestion and absorption

Molecular Function:

  • Antioxidant Activity
  • Cholesterol Binding
  • Cholesterol Transporter Activity
  • Copper Ion Binding
  • Lipid Binding
  • Lipid Transporter Activity
  • Phosphatidylcholine Binding
  • Phosphatidylcholine-Sterol O-Acyltransferase Activator Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Cellular Protein Metabolic Process
  • Cholesterol Biosynthetic Process
  • Cholesterol Efflux
  • Cholesterol Homeostasis
  • Cholesterol Metabolic Process
  • Chylomicron Assembly
  • Chylomicron Remodeling
  • High-Density Lipoprotein Particle Assembly
  • High-Density Lipoprotein Particle Remodeling
  • Hydrogen Peroxide Catabolic Process
  • Innate Immune Response In Mucosa
  • Leukocyte Cell-Cell Adhesion
  • Lipid Homeostasis
  • Lipid Transport
  • Lipoprotein Biosynthetic Process
  • Lipoprotein Metabolic Process
  • Multicellular Organismal Lipid Catabolic Process
  • Negative Regulation Of Plasma Lipoprotein Particle Oxidation
  • Neuron Projection Regeneration
  • Phosphatidylcholine Metabolic Process
  • Phospholipid Efflux
  • Positive Regulation Of Cholesterol Esterification
  • Positive Regulation Of Fatty Acid Biosynthetic Process
  • Positive Regulation Of Lipoprotein Lipase Activity
  • Positive Regulation Of Triglyceride Catabolic Process
  • Protein-Lipid Complex Assembly
  • Regulation Of Cholesterol Transport
  • Regulation Of Intestinal Cholesterol Absorption
  • Removal Of Superoxide Radicals
  • Response To Lipid Hydroperoxide
  • Response To Stilbenoid
  • Retinoid Metabolic Process
  • Reverse Cholesterol Transport
  • Triglyceride Homeostasis
  • Very-Low-Density Lipoprotein Particle Remodeling
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| apolipoprotein A-I| apoa1| Apoa-4| apoAIV| Apo-AIV| APOA-IV| apolipoprotein A-IV| Apolipoprotein A-V| GW7_10780| H920_07539| I79_019550| MDA_GLEAN10018939| myh11| PAL_GLEAN10009074| PANDA_008178| putative apolipoprotein A1| TREES_T100002982| UY3_07696| apoa4

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