The Function of APOA4
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
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Protein names
Recommended name:
Apolipoprotein A-IVAlternative name(s):
Apo-AIVApoA-IV
Apolipoprotein A4
- RS1263173 (APOA4) ??
- RS5092 (APOA4) ??
- RS5104 (APOA4) ??
- RS5110 (APOA4) ??
- RS662799 (APOA4) ??
- RS7396835 (APOA4) ??
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Top Gene-Substance Interactions
APOA4 Interacts with These Diseases
| Disease | Score |
Substances That Increase APOA4
| Substances | Interaction | Organism | Category |
Substances That Decrease APOA4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Synthesized primarily in the intestine and secreted in plasma.
Gene Pathways:
Molecular Function:
- Lipid Transporter Activity
- Copper Ion Binding
- Lipid Binding
- Cholesterol Binding
- Antioxidant Activity
- Cholesterol Transporter Activity
- Phosphatidylcholine Binding
- Protein Homodimerization Activity
- Phosphatidylcholine-Sterol O-Acyltransferase Activator Activity
Biological Processes:
- Retinoid Metabolic Process
- Innate Immune Response In Mucosa
- Cholesterol Biosynthetic Process
- Lipid Transport
- Response To Lipid Hydroperoxide
- Leukocyte Cell-Cell Adhesion
- Cholesterol Metabolic Process
- Positive Regulation Of Cholesterol Esterification
- Positive Regulation Of Triglyceride Catabolic Process
- Removal Of Superoxide Radicals
- Regulation Of Intestinal Cholesterol Absorption
- Neuron Projection Regeneration
- Regulation Of Cholesterol Transport
- Cholesterol Efflux
- Phospholipid Efflux
- Chylomicron Remodeling
- Very-Low-Density Lipoprotein Particle Remodeling
- High-Density Lipoprotein Particle Remodeling
- Chylomicron Assembly
- High-Density Lipoprotein Particle Assembly
- Negative Regulation Of Plasma Lipoprotein Particle Oxidation
- Response To Stilbenoid
- Lipoprotein Metabolic Process
- Lipoprotein Biosynthetic Process
- Cholesterol Homeostasis
- Hydrogen Peroxide Catabolic Process
- Reverse Cholesterol Transport
- Multicellular Organismal Lipid Catabolic Process
- Cellular Protein Metabolic Process
- Positive Regulation Of Fatty Acid Biosynthetic Process
- Phosphatidylcholine Metabolic Process
- Positive Regulation Of Lipoprotein Lipase Activity
- Lipid Homeostasis
- Protein-Lipid Complex Assembly
- Triglyceride Homeostasis