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  3. APOA2

APOA2 (Apolipoprotein A2)

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The Function of APOA2

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

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Protein names

Recommended name:

Apolipoprotein A-II

Alternative name(s):

Apo-AII
ApoA-II
Apolipoprotein A2
ProapoA-II
Apolipoprotein A-II(1-76

APOA2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS5082 (APOA2) ??
  2. RS6413453 (APOA2) ??

Top Gene-Substance Interactions

APOA2 Interacts with These Diseases

Disease Score

Substances That Increase APOA2

Substances Interaction Organism Category

Substances That Decrease APOA2

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Familial hypercholesterolemia

     From NCBI Gene: This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008] From UniProt: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Plasma; synthesized in the liver and intestine.

Gene Pathways:

  • Metabolism
  • Disease
  • Signal Transduction
  • PPAR signaling pathway

Molecular Function:

  • Apolipoprotein Receptor Binding
  • Cholesterol Binding
  • Cholesterol Transporter Activity
  • High-Density Lipoprotein Particle Binding
  • High-Density Lipoprotein Particle Receptor Binding
  • Lipase Inhibitor Activity
  • Lipid Binding
  • Lipid Transporter Activity
  • Phosphatidylcholine Binding
  • Phosphatidylcholine-Sterol O-Acyltransferase Activator Activity
  • Phospholipid Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Acute Inflammatory Response
  • Animal Organ Regeneration
  • Cholesterol Efflux
  • Cholesterol Homeostasis
  • Cholesterol Metabolic Process
  • Diacylglycerol Catabolic Process
  • High-Density Lipoprotein Particle Assembly
  • High-Density Lipoprotein Particle Clearance
  • High-Density Lipoprotein Particle Remodeling
  • Lipoprotein Biosynthetic Process
  • Lipoprotein Metabolic Process
  • Low-Density Lipoprotein Particle Remodeling
  • Negative Regulation Of Cholesterol Import
  • Negative Regulation Of Cholesterol Transport
  • Negative Regulation Of Cholesterol Transporter Activity
  • Negative Regulation Of Cytokine Secretion Involved In Immune Response
  • Negative Regulation Of Lipase Activity
  • Negative Regulation Of Lipid Catabolic Process
  • Negative Regulation Of Very-Low-Density Lipoprotein Particle Remodeling
  • Peptidyl-Methionine Modification
  • Phosphatidylcholine Biosynthetic Process
  • Phospholipid Catabolic Process
  • Phospholipid Efflux
  • Positive Regulation Of Cholesterol Esterification
  • Positive Regulation Of Interleukin-8 Biosynthetic Process
  • Positive Regulation Of Lipid Catabolic Process
  • Protein Oxidation
  • Regulation Of Intestinal Cholesterol Absorption
  • Regulation Of Protein Stability
  • Response To Estrogen
  • Response To Glucocorticoid
  • Response To Glucose
  • Retinoid Metabolic Process
  • Reverse Cholesterol Transport
  • Triglyceride Metabolic Process
  • Triglyceride-Rich Lipoprotein Particle Remodeling
  • Viral Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AFP4| Alp-2| antimicrobial peptide BAMP-1| Apoa-2| apoA-II| Apo-AII| APOAII| apolipoprotein A-II| apolipoprotein A-II-like protein| apolipoprotein A-II preproprotein| CB1_000141026| EGK_01534| GW7_00499| H920_20455| Hdl-1| PAL_GLEAN10017941| PANDA_018831| TREES_T100011136| Type-4 ice-structuring protein LS-12| uncharacterized protein LOC322327| apoa2

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