The Function of APOA2
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Protein names
Recommended name:
Apolipoprotein A-IIAlternative name(s):
Apo-AIIApoA-II
Apolipoprotein A2
ProapoA-II
Apolipoprotein A-II(1-76
- RS5082 (APOA2) ??
- RS6413453 (APOA2) ??
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Top Gene-Substance Interactions
APOA2 Interacts with These Diseases
| Disease | Score |
Substances That Increase APOA2
| Substances | Interaction | Organism | Category |
Substances That Decrease APOA2
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Familial hypercholesterolemia
From NCBI Gene: This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008] From UniProt: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Plasma; synthesized in the liver and intestine.
Gene Pathways:
Molecular Function:
- Apolipoprotein Receptor Binding
- Cholesterol Binding
- Cholesterol Transporter Activity
- High-Density Lipoprotein Particle Binding
- High-Density Lipoprotein Particle Receptor Binding
- Lipase Inhibitor Activity
- Lipid Binding
- Lipid Transporter Activity
- Phosphatidylcholine Binding
- Phosphatidylcholine-Sterol O-Acyltransferase Activator Activity
- Phospholipid Binding
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
Biological Processes:
- Acute Inflammatory Response
- Animal Organ Regeneration
- Cholesterol Efflux
- Cholesterol Homeostasis
- Cholesterol Metabolic Process
- Diacylglycerol Catabolic Process
- High-Density Lipoprotein Particle Assembly
- High-Density Lipoprotein Particle Clearance
- High-Density Lipoprotein Particle Remodeling
- Lipoprotein Biosynthetic Process
- Lipoprotein Metabolic Process
- Low-Density Lipoprotein Particle Remodeling
- Negative Regulation Of Cholesterol Import
- Negative Regulation Of Cholesterol Transport
- Negative Regulation Of Cholesterol Transporter Activity
- Negative Regulation Of Cytokine Secretion Involved In Immune Response
- Negative Regulation Of Lipase Activity
- Negative Regulation Of Lipid Catabolic Process
- Negative Regulation Of Very-Low-Density Lipoprotein Particle Remodeling
- Peptidyl-Methionine Modification
- Phosphatidylcholine Biosynthetic Process
- Phospholipid Catabolic Process
- Phospholipid Efflux
- Positive Regulation Of Cholesterol Esterification
- Positive Regulation Of Interleukin-8 Biosynthetic Process
- Positive Regulation Of Lipid Catabolic Process
- Protein Oxidation
- Regulation Of Intestinal Cholesterol Absorption
- Regulation Of Protein Stability
- Response To Estrogen
- Response To Glucocorticoid
- Response To Glucose
- Retinoid Metabolic Process
- Reverse Cholesterol Transport
- Triglyceride Metabolic Process
- Triglyceride-Rich Lipoprotein Particle Remodeling
- Viral Process