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  3. APIP

APIP (APAF1 interacting protein)

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The Function of APIP

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.

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Protein names

Recommended name:

Methylthioribulose-1-phosphate dehydratase

Alternative name(s):

MTRu-1-P dehydratase
APAF1-interacting protein
hAPIP

Top Gene-Substance Interactions

Substances That Increase APIP

Substances Interaction Organism Category

Substances That Decrease APIP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GATA-1
  • E2F-1
  • IRF-2
  • YY1
  • AREB6
  • GATA-2
  • GATA-3

Tissue specificity:

Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Identical Protein Binding
  • Methylthioribulose 1-Phosphate Dehydratase Activity
  • Zinc Ion Binding

Biological Processes:

  • Apoptotic Process
  • L-Methionine Biosynthetic Process From Methylthioadenosine
  • L-Methionine Biosynthetic Process From S-Adenosylmethionine
  • Negative Regulation Of Apoptotic Process
  • Protein Homotetramerization
  • Pyroptosis
  • Regulation Of Erk1 And Erk2 Cascade
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11417| APAF1-interacting protein homolog| apaf1-interacting protein-like protein| APAF1-interacting protein like protein| APIP2| AS27_11458| AS28_05422| CB1_056579021| CGI29| CGI-29| GW7_08863| H920_18758| hAPIP| M91_01243| M959_02321| MDA_GLEAN10011621| methylthioribulose-1-phosphate dehydratase| Mmrp19| monocyte macrophage 19| monocyte/macrophage protein 19| MTRu-1-P dehydratase| N300_01956| N301_14126| N302_01517| N303_00228| N305_03436| N306_09615| N307_09665| N308_05658| N309_13098| N311_02240| N312_02926| N320_09293| N321_14242| N322_08053| N324_04712| N325_02621| N326_09793| N327_01905| N328_09798| N329_10497| N330_04124| N332_06541| N333_00972| N334_08358| N335_04274| N336_00516| N339_07561| N340_02129| PANDA_009415| probable methylthioribulose-1-phosphate dehydratase| putative methylthioribulose-1-phosphate dehydratase| putative methylthioribulose-1-phosphate dehydratase-like protein| RGD1564562| TREES_T100002090| UY3_14818| Y1Q_007746| Y956_14754| Z169_07903| apip

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