The Function of APIP
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
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Protein names
Recommended name:
Methylthioribulose-1-phosphate dehydrataseAlternative name(s):
MTRu-1-P dehydrataseAPAF1-interacting protein
hAPIP
Top Gene-Substance Interactions
Substances That Increase APIP
| Substances | Interaction | Organism | Category |
Substances That Decrease APIP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
Biological Processes:
- Apoptotic Process
- L-Methionine Biosynthetic Process From Methylthioadenosine
- L-Methionine Biosynthetic Process From S-Adenosylmethionine
- Negative Regulation Of Apoptotic Process
- Protein Homotetramerization
- Pyroptosis
- Regulation Of Erk1 And Erk2 Cascade