The Function of APCS
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
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Protein names
Recommended name:
Serum amyloid P-componentShort name:
SAPAlternative name(s):
9.5S alpha-1-glycoprotein1-203
- RS12093699 (APCS) ??
- RS16827466 (APCS) ??
- RS16842559 (APCS) ??
- RS2592902 (APCS) ??
- RS2794520 (APCS) ??
- RS2808630 (APCS) ??
- RS726640 (APCS) ??
- RS876537 (APCS) ??
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Top Gene-Substance Interactions
APCS Interacts with These Diseases
| Disease | Score |
Substances That Increase APCS
| Substances | Interaction | Organism | Category |
Substances That Decrease APCS
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Found in serum and urine.
Gene Pathways:
Cofactor:
Binds 2 calcium ions per subunit.
Molecular Function:
- Complement Component C1q Binding
- Calcium Ion Binding
- Carbohydrate Binding
- Virion Binding
- Unfolded Protein Binding
Biological Processes:
- Negative Regulation Of Acute Inflammatory Response
- Protein Folding
- Acute-Phase Response
- Cellular Protein Metabolic Process
- Negative Regulation By Host Of Viral Exo-Alpha-Sialidase Activity
- Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
- Innate Immune Response
- Negative Regulation Of Monocyte Differentiation
- Negative Regulation Of Viral Entry Into Host Cell
- Negative Regulation Of Viral Process
- Chaperone-Mediated Protein Complex Assembly
- Negative Regulation Of Wound Healing
- Negative Regulation Of Exo-Alpha-Sialidase Activity
- Negative Regulation Of Glycoprotein Metabolic Process