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  3. APCS

APCS (Amyloid P component, serum)

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The Function of APCS

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

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Protein names

Recommended name:

Serum amyloid P-component

Short name:

SAP

Alternative name(s):

9.5S alpha-1-glycoprotein
1-203

APCS SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12093699 (APCS) ??
  2. RS16827466 (APCS) ??
  3. RS16842559 (APCS) ??
  4. RS2592902 (APCS) ??
  5. RS2794520 (APCS) ??
  6. RS2808630 (APCS) ??
  7. RS726640 (APCS) ??
  8. RS876537 (APCS) ??

Top Gene-Substance Interactions

APCS Interacts with These Diseases

Disease Score

Substances That Increase APCS

Substances Interaction Organism Category

Substances That Decrease APCS

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • STAT3
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • STAT5A
  • STAT1
  • c-Rel
  • GATA-3

Tissue specificity:

Found in serum and urine.

Gene Pathways:

  • Disease

Cofactor:

Binds 2 calcium ions per subunit.

Molecular Function:

  • Calcium Ion Binding
  • Carbohydrate Binding
  • Complement Component C1q Binding
  • Unfolded Protein Binding
  • Virion Binding

Biological Processes:

  • Acute-Phase Response
  • Cellular Protein Metabolic Process
  • Chaperone-Mediated Protein Complex Assembly
  • Innate Immune Response
  • Negative Regulation By Host Of Viral Exo-Alpha-Sialidase Activity
  • Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
  • Negative Regulation Of Acute Inflammatory Response
  • Negative Regulation Of Exo-Alpha-Sialidase Activity
  • Negative Regulation Of Glycoprotein Metabolic Process
  • Negative Regulation Of Monocyte Differentiation
  • Negative Regulation Of Viral Entry Into Host Cell
  • Negative Regulation Of Viral Process
  • Negative Regulation Of Wound Healing
  • Protein Folding
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 9.5S alpha-1-glycoprotein| amyloid P component, serum protein| APCS amyloid P-component serum protein| C-reactive protein| epididymis secretory sperm binding protein Li 92n| Female protein| FP| GW7_00543| H920_20499| HEL-S-92n| I79_006495| N301_04253| PANDA_019673| pentaxin-related| pentraxin| pentraxin-2| pentraxin-related| ptx2| SAP| SAP(FP)| serum amyloid P component| Serum amyloid P-component| TREES_T100018289| apcs

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