• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. APC

APC (APC, WNT signaling pathway regulator)

Loading...

Summary of APC

The APC gene encodes APC protein, which plays a critical role in several cellular processes. It acts as a tumor suppressor by helping control how often a cell divides and it helps ensure that the number of chromosomes in a cell is correct following cell division (R).

Mutations of this gene are associated with higher risk for many different types of cancer (R).

0 users want this gene increased, 0 users want it decreased

The Function of APC

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Protein names

Recommended name:

Adenomatous polyposis coli protein

Alternative name(s):

Protein APC
Deleted in polyposis 2.5

APC SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1801155 (APC) ??
  2. RS1804197 (APC) ??
  3. RS2229992 (APC) ??
  4. RS2431238 (APC) ??
  5. RS351771 (APC) ??
  6. RS454886 (APC) ??
  7. RS459552 (APC) ??

Top Gene-Substance Interactions

APC Interacts with These Diseases

Disease Score

Substances That Increase APC

Substances Interaction Organism Category

Substances That Decrease APC

Substances Interaction Organism Category

Advanced Summary

     desmoid tumor Several mutations in the APC gene have been found in people with a type of aggressive but noncancerous (benign) growth called a desmoid tumor. These rare tumors arise from connective tissue, which provides strength and flexibility to structures such as bones, ligaments, and muscles. APC gene mutations typically cause formation of desmoid tumors in the abdomen, but these tumors can also occur in other parts of the body. Although APC-related desmoid tumors are commonly associated with a form of colon cancer called familial adenomatous polyposis (described below), APC gene mutations can cause tumors in individuals without this inherited disease. APC gene mutations are found in about 10 to 15 percent of non-inherited (sporadic) desmoid tumors; these mutations are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. Most APC gene mutations that cause sporadic desmoid tumors lead to an abnormally short APC protein. The shortened protein is unable to interact with the beta-catenin protein, which prevents the breakdown of beta-catenin when it is no longer needed. Excess beta-catenin promotes uncontrolled growth and division of cells, allowing the formation of desmoid tumors. familial adenomatous polyposis More than 700 mutations in the APC gene have been identified in families with the classic and attenuated types of familial adenomatous polyposis (FAP). Most of these mutations lead to the production of an abnormally short, nonfunctional version of the APC protein. This short protein cannot suppress the cellular overgrowth that leads to the formation of abnormal growths (polyps) in the colon, which can become cancerous. The most common mutation in FAP is a deletion of five building blocks of DNA (nucleotides) in the APC gene. This mutation changes the sequence of the building blocks of proteins (amino acids) in the resulting APC protein. Although most people with FAP will develop colorectal cancer, the number of polyps and the time frame in which they become cancerous depend on the location of the mutation in the APC gene. The location of the mutation also determines whether an individual with FAP is predisposed to developing desmoid tumors (described above). primary macronodular adrenal hyperplasia Genetics Home Reference provides information about primary macronodular adrenal hyperplasia. other cancers Mutations in the APC gene are also responsible for a disorder called Turcot syndrome, which is closely related to familial adenomatous polyposis. Turcot syndrome is an association of colorectal cancer with a type of cancerous brain tumor called a medulloblastoma. Approximately two-thirds of people with Turcot syndrome have mutations in the APC gene. A certain mutation in the APC gene (unrelated to Turcot syndrome) is found in approximately 6 percent of people with Ashkenazi (eastern and central European) Jewish heritage. This mutation replaces the amino acid isoleucine with the amino acid lysine at position 1307 in the APC protein (written as Ile1307Lys or I1307K). This change was initially thought to be harmless, but has been shown to be associated with a 10 percent to 20 percent increased risk of colon cancer. Somatic mutations in the APC gene may be involved in the development of a small percentage of stomach (gastric) cancers.

     The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. It helps control how often a cell divides, how it attaches to other cells within a tissue, and whether a cell moves within or away from a tissue. This protein also helps ensure that the number of chromosomes in a cell is correct following cell division. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling. One protein with which APC associates is beta-catenin. Beta-catenin helps control the activity (expression) of particular genes and promotes the growth and division (proliferation) of cells and the process by which cells mature to carry out specific functions (differentiation). Beta-catenin also helps cells attach to one another and is important for tissue formation. Association of APC with beta-catenin signals for beta-catenin to be broken down when it is no longer needed.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Max
  • C/EBPbeta
  • HNF-4alpha1
  • HNF-4alpha2
  • c-Myc
  • NF-1
  • Pax-2

Tissue specificity:

Expressed in a variety of tissues.

Gene Pathways:

  • Apoptosis
  • Pathways in cancer
  • Disease
  • Basal cell carcinoma
  • Wnt signaling pathway
  • Colorectal cancer
  • Endometrial cancer
  • Signal Transduction
  • Regulation of actin cytoskeleton

Molecular Function:

  • Beta-Catenin Binding
  • Gamma-Catenin Binding
  • Microtubule Binding
  • Microtubule Plus-End Binding
  • Protein Kinase Binding
  • Protein Kinase Regulator Activity

Biological Processes:

  • Beta-Catenin Destruction Complex Assembly
  • Beta-Catenin Destruction Complex Disassembly
  • Bicellular Tight Junction Assembly
  • Canonical Wnt Signaling Pathway
  • Cell Adhesion
  • Cell Cycle Arrest
  • Cell Fate Specification
  • Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
  • Cellular Response To Dna Damage Stimulus
  • Mitotic Cytokinesis
  • Mitotic Spindle Assembly Checkpoint
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Negative Regulation Of Microtubule Depolymerization
  • Pattern Specification Process
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Protein Catabolic Process
  • Positive Regulation Of Pseudopodium Assembly
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Protein Complex Assembly
  • Regulation Of Attachment Of Spindle Microtubules To Kinetochore
  • Regulation Of Cell Differentiation
  • Regulation Of Microtubule-Based Process
  • Wnt Signaling Pathway
  • Cellular Response To Nerve Growth Factor Stimulus
  • Establishment Or Maintenance Of Cell Polarity
  • Neuron Projection Development
  • Pancreas Development
  • Regulation Of Glutamate Metabolic Process
  • Response To Alcohol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Uncharacterized protein| Apc1| adenomatosis polyposis coli| adenomatosis polyposis coli tumor suppressor| adenomatous polyposis coli| adenomatous polyposis coli 1| adenomatous polyposis coli homolog| Adenomatous polyposis coli protein| Adenomatous polyposis coli protein-like protein| Anapl_16757| apc 1| APC-like| Apc-PA| Apc-PB| Apc-PC| AS27_13790| BTPS2| CB1_001814002| CC1| CG1451 gene product from transcript CG1451-RA| CG1451-PA| CG1451-PB| CG1451-PC| CTC-554D6.1| D623_10033156| d-APC| DAPC| dapc1| D-APC1| deleted in polyposis 2.5| Dm APC1| Dmel_CG1451| dp2| DP2.5| dp3| fap| fpc| GS| H920_16592| I79_009159| mAPC| MDA_GLEAN10021781| Min| multiple intestinal neoplasia| N300_08310| N301_02940| N303_08338| N305_04029| N307_00270| N308_12198| N309_02470| N310_07922| N311_06165| N312_12512| N320_10555| N321_01168| N322_00448| N324_02750| N327_03432| N328_10353| N329_07099| N331_11190| N334_09540| N339_11901| N340_13064| PAL_GLEAN10025035| PANDA_007820| PPP1R46| protein phosphatase 1, regulatory subunit 46| RATAPC| TREES_T100014640| truncated adenomatosis polyposis coli| UY3_02864| WNT signaling pathway regulator| xapc| Y1Q_011030| Y956_01579| Z169_06252| apc

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved