The Function of APBB1IP
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
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Protein names
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 1-interacting proteinShort name:
RIAMAlternative name(s):
APBB1-interacting protein 1Proline-rich EVH1 ligand 1
PREL-1
Proline-rich protein 73
Rap1-GTP-interacting adapter molecule
Retinoic acid-responsive proline-rich protein 1
RARP-1
- RS2992257 (APBB1IP) ??
- RS786870 (APBB1IP) ??
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Top Gene-Substance Interactions
Substances That Increase APBB1IP
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Substances That Decrease APBB1IP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
Gene Pathways:
Induction:
By all-trans-retinoic acid (ATRA).
Biological Processes:
- Positive Regulation Of Cell Adhesion
- Signal Transduction
- T Cell Activation Via T Cell Receptor Contact With Antigen Bound To Mhc Molecule On Antigen Presenting Cell