The Function of AP3S2
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
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Protein names
Recommended name:
AP-3 complex subunit sigma-2Alternative name(s):
AP-3 complex subunit sigma-3BAdaptor-related protein complex 3 subunit sigma-2
Sigma-3B-adaptin
Sigma3B-adaptin
Sigma-adaptin 3b
- RS2028299 (AP3S2) ??
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Top Gene-Substance Interactions
Substances That Increase AP3S2
| Substances | Interaction | Organism | Category |
Substances That Decrease AP3S2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Present in all adult tissues examined.