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  3. ANXA1

ANXA1 (Annexin A1)

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The Function of ANXA1

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton.

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Protein names

Recommended name:

Annexin A1

Alternative name(s):

Annexin I
Annexin-1
Calpactin II
Calpactin-2
Chromobindin-9
Lipocortin I
Phospholipase A2 inhibitory protein
p35

ANXA1 SNPs

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  1. RS3758354 (ANXA1) ??

Top Gene-Substance Interactions

ANXA1 Interacts with These Diseases

Disease Score

Substances That Increase ANXA1

Substances Interaction Organism Category

Substances That Decrease ANXA1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • STAT3
  • C/EBPalpha
  • STAT5A

Tissue specificity:

Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.

Gene Pathways:

  • Signal Transduction

Molecular Function:

  • Annealing Helicase Activity
  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Calcium-Dependent Phospholipid Binding
  • Calcium-Dependent Protein Binding
  • Calcium Ion Binding
  • Double-Stranded Dna-Dependent Atpase Activity
  • Helicase Activity
  • Phospholipase A2 Inhibitor Activity
  • Phospholipid Binding
  • Protein Binding, Bridging
  • Receptor Binding
  • Single-Stranded Dna Binding
  • Single-Stranded Rna Binding
  • Structural Molecule Activity

Biological Processes:

  • Actin Cytoskeleton Reorganization
  • Adaptive Immune Response
  • Alpha-Beta T Cell Differentiation
  • Arachidonic Acid Secretion
  • Cell Surface Receptor Signaling Pathway
  • Cellular Response To Glucocorticoid Stimulus
  • Cellular Response To Hydrogen Peroxide
  • Dna Duplex Unwinding
  • Dna Rewinding
  • Endocrine Pancreas Development
  • Estrous Cycle
  • Gliogenesis
  • G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
  • Granulocyte Chemotaxis
  • Hepatocyte Differentiation
  • Inflammatory Response
  • Innate Immune Response
  • Insulin Secretion
  • Keratinocyte Differentiation
  • Monocyte Chemotaxis
  • Myoblast Migration Involved In Skeletal Muscle Regeneration
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Exocytosis
  • Negative Regulation Of Interleukin-8 Secretion
  • Negative Regulation Of Phospholipase A2 Activity
  • Negative Regulation Of T-Helper 2 Cell Differentiation
  • Neutrophil Clearance
  • Neutrophil Homeostasis
  • Peptide Cross-Linking
  • Phagocytosis
  • Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
  • Positive Regulation Of Interleukin-2 Production
  • Positive Regulation Of Neutrophil Apoptotic Process
  • Positive Regulation Of Prostaglandin Biosynthetic Process
  • Positive Regulation Of T Cell Proliferation
  • Positive Regulation Of T-Helper 1 Cell Differentiation
  • Positive Regulation Of Vesicle Fusion
  • Positive Regulation Of Wound Healing
  • Prolactin Secretion
  • Prostate Gland Development
  • Regulation Of Cell Shape
  • Regulation Of Hormone Secretion
  • Regulation Of Inflammatory Response
  • Regulation Of Interleukin-1 Production
  • Regulation Of Leukocyte Migration
  • Response To Estradiol
  • Response To Interleukin-1
  • Response To Peptide Hormone
  • Response To X-Ray
  • Signal Transduction

Drug Bank:

  • Hydrocortisone
  • Amcinonide
  • Dexamethasone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_19050| Annexin-1| Annexin 1 (p35) (Lipocortin 1)| Annexin A1 isoform p37| annexin A1-like protein| annexin I| annexin I (lipocortin I)| annexin max3| anx1| Anx-1| Anx-A1| ANXA1-like protein| AS27_02947| AS28_10927| calcium-dependent membrane binding protein annexin I| calpactin-2| calpactin II| CB1_002439004| chromobindin-9| D623_10034424| EH28_12057| GW7_17325| lipocortin 1| lipocortin-1| lipocortin I| lpc1| Lpc-1| M959_12114| N300_09204| N301_11846| N302_05743| N305_12184| N306_02603| N307_02646| N309_04099| N310_03429| N311_06344| N312_02321| N320_07354| N321_03780| N322_11580| N325_01392| N326_11274| N327_12189| N328_10662| N329_08452| N330_10857| N331_11681| N332_11839| N333_11311| N334_05799| N335_03546| N336_11555| N339_05452| N340_12382| N341_04603| p35| PAL_GLEAN10021096| PANDA_020850| phospholipase A2 inhibitory protein| TREES_T100014487| UY3_12431| XELAEV_18010117mg| Y1Q_022271| Y956_14686| Z169_08589| anxa1

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