The Function of ANXA1
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton.
Protein names
Recommended name:
Annexin A1Alternative name(s):
Annexin IAnnexin-1
Calpactin II
Calpactin-2
Chromobindin-9
Lipocortin I
Phospholipase A2 inhibitory protein
p35
- RS3758354 (ANXA1) ??
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Top Gene-Substance Interactions
ANXA1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ANXA1
| Substances | Interaction | Organism | Category |
Substances That Decrease ANXA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
Gene Pathways:
Molecular Function:
- Single-Stranded Dna Binding
- Single-Stranded Rna Binding
- Helicase Activity
- Receptor Binding
- Structural Molecule Activity
- Calcium Ion Binding
- Phospholipid Binding
- Calcium-Dependent Phospholipid Binding
- Phospholipase A2 Inhibitor Activity
- Protein Binding, Bridging
- Double-Stranded Dna-Dependent Atpase Activity
- Annealing Helicase Activity
- Calcium-Dependent Protein Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Neutrophil Homeostasis
- Adaptive Immune Response
- Monocyte Chemotaxis
- Regulation Of Leukocyte Migration
- Phagocytosis
- Inflammatory Response
- Signal Transduction
- Cell Surface Receptor Signaling Pathway
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Regulation Of Cell Shape
- Response To X-Ray
- Myoblast Migration Involved In Skeletal Muscle Regeneration
- Peptide Cross-Linking
- Insulin Secretion
- Keratinocyte Differentiation
- Prostate Gland Development
- Endocrine Pancreas Development
- Positive Regulation Of Vesicle Fusion
- Positive Regulation Of Prostaglandin Biosynthetic Process
- Actin Cytoskeleton Reorganization
- Response To Estradiol
- Dna Duplex Unwinding
- Regulation Of Interleukin-1 Production
- Positive Regulation Of Interleukin-2 Production
- Positive Regulation Of Neutrophil Apoptotic Process
- Dna Rewinding
- Gliogenesis
- Positive Regulation Of T Cell Proliferation
- Negative Regulation Of Apoptotic Process
- Response To Peptide Hormone
- Estrous Cycle
- Innate Immune Response
- Positive Regulation Of T-Helper 1 Cell Differentiation
- Negative Regulation Of T-Helper 2 Cell Differentiation
- Negative Regulation Of Exocytosis
- Alpha-Beta T Cell Differentiation
- Regulation Of Hormone Secretion
- Arachidonic Acid Secretion
- Regulation Of Inflammatory Response
- Cellular Response To Hydrogen Peroxide
- Hepatocyte Differentiation
- Prolactin Secretion
- Response To Interleukin-1
- Cellular Response To Glucocorticoid Stimulus
- Granulocyte Chemotaxis
- Positive Regulation Of Wound Healing
- Neutrophil Clearance
- Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Negative Regulation Of Phospholipase A2 Activity
- Negative Regulation Of Interleukin-8 Secretion