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  3. ANLN

ANLN (Anillin actin binding protein)

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The Function of ANLN

Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636).

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Protein names

Recommended name:

Anillin

ANLN SNPs

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  1. RS7777593 (ANLN) ??

Top Gene-Substance Interactions

ANLN Interacts with These Diseases

Disease Score

Substances That Increase ANLN

Substances Interaction Organism Category

Substances That Decrease ANLN

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1

Tissue specificity:

Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

Developmental stage:

Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus. In dividing cells expression increases during S and G2 phases, peaks at mitosis and subsequently drops as cells enter G1 phase.

Molecular Function:

  • Actin Binding
  • Cadherin Binding Involved In Cell-Cell Adhesion

Biological Processes:

  • Glomerular Visceral Epithelial Cell Migration
  • Hematopoietic Progenitor Cell Differentiation
  • Mitotic Cytokinesis
  • Mitotic Nuclear Division
  • Regulation Of Exit From Mitosis
  • Septin Ring Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_12698| Actin-binding protein anillin| actin-binding protein anillin-like protein| anillin| anillin, actin binding protein| anillin, actin binding protein (scraps homolog, Drosophila)| AS27_07435| AS28_12253| C78101| CB1_001541011| D623_10020100| EGK_13772| fb74d05| fd10d09| FSGS8| H920_12246| M91_01557| MDA_GLEAN10022065| N300_04811| N301_15124| N302_16021| N303_06627| N305_08343| N306_09355| N307_10353| N310_02725| N311_08864| N312_03776| N320_13310| N322_12287| N324_04522| N325_01918| N326_01255| N327_01061| N328_07126| N329_06574| N330_03834| N331_03045| N333_02335| N335_00965| N336_09591| N339_06336| N340_13950| N341_11216| PAL_GLEAN10021926| PANDA_007199| RGD1561367| scra| scraps| TREES_T100002576| UY3_12730| Y1Q_021490| Y956_11350| Z169_12176| anln

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