The Function of ANLN
Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636).
Protein names
Recommended name:
Anillin- RS7777593 (ANLN) ??
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Top Gene-Substance Interactions
ANLN Interacts with These Diseases
Disease | Score |
Substances That Increase ANLN
Substances | Interaction | Organism | Category |
Substances That Decrease ANLN
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Developmental stage:
Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus. In dividing cells expression increases during S and G2 phases, peaks at mitosis and subsequently drops as cells enter G1 phase.
Molecular Function:
Biological Processes:
- Glomerular Visceral Epithelial Cell Migration
- Hematopoietic Progenitor Cell Differentiation
- Mitotic Cytokinesis
- Mitotic Nuclear Division
- Regulation Of Exit From Mitosis
- Septin Ring Assembly