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  3. ANGPTL4

ANGPTL4 (Angiopoietin like 4)

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Summary of ANGPTL4

This protein acts as survival and protective factor for vessel endothelial cells.  Inhibits tumors (proliferation, migration) and reduces vascular leakage.

It functions as a hormone that regulates glucose and cholesterol balance, and insulin sensitivity.

Decreased expression of this gene has been associated with type 2 diabetes. 

It's better to have this gene increased most of the time.
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Protein names

Recommended name:

Angiopoietin-related protein 4

Short name:

HFARP

Alternative name(s):

Angiopoietin-like protein 4
Hepatic fibrinogen/angiopoietin-related protein

ANGPTL4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1044250 (ANGPTL4) ??
  2. RS11672433 (ANGPTL4) ??
  3. RS116843064 (ANGPTL4) ??
  4. RS2278236 (ANGPTL4) ??
  5. RS7255436 (ANGPTL4) ??

Top Gene-Substance Interactions

ANGPTL4 Interacts with These Diseases

Disease Score

Substances That Increase ANGPTL4

Substances Interaction Organism Category

Substances That Decrease ANGPTL4

Substances Interaction Organism Category

Advanced Summary

Protein with hypoxia-induced expression in endothelial cells.  In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM).

The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

The encoded protein is induced by all PPARs.

 

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • PPAR-alpha
  • FOXO1a
  • FOXO1
  • PPAR-delta

Tissue specificity:

Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.

Gene Pathways:

  • Metabolism
  • PPAR signaling pathway

Molecular Function:

  • Enzyme Inhibitor Activity
  • Identical Protein Binding

Biological Processes:

  • Angiogenesis
  • Cell Differentiation
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Endothelial Cell Apoptotic Process
  • Negative Regulation Of Lipoprotein Lipase Activity
  • Positive Regulation Of Angiogenesis
  • Protein Homooligomerization
  • Response To Hypoxia
  • Triglyceride Homeostasis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| angiopoietin-like 3| 425O18-1| A306_12861| angiopoietin-like 4| angiopoietin-like 4 protein| angiopoietin-like protein 4| angiopoietin-like secreted glycoprotein 4| Angiopoietin-related protein 4| Arp4| AS27_07576| AS28_06877| Bk89| CB1_000765042| D623_10012528| fasting-induced adipose factor| fiaf| fibrinogen/angiopoietin-related protein| H920_15639| HARP| hepatic angiopoietin-related protein| hepatic fibrinogen/angiopoietin-related protein| HFARP| M959_02117| major histocompatibility complex region NG27| N300_08728| N301_14582| N302_02442| N303_13670| N305_04623| N307_11961| N308_00325| N310_12018| N311_05990| N312_08365| N320_04650| N321_05910| N322_06447| N324_04532| N325_10236| N327_05966| N328_06235| N329_02851| N330_07391| N331_06074| N332_08471| N333_13556| N334_05903| N335_11270| N336_09019| N339_07884| N340_05312| N341_01050| Ng27| NL2| PAL_GLEAN10002099| PANDA_018337| peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein| Pgar| Pgarg| pp1158| PPARG angiopoietin related protein| PPARG angiopoietin-related protein| secreted protein Bk89| TGQTL| UNQ171| UY3_06648| Y1Q_019378| Y956_15709| Z169_08463| angptl4

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