Summary of ANGPTL4
The ANGPTL4 gene encodes angiopoietin like protein 4 [R].
ANGPTL4 prevents the death of cells that make up the walls of blood vessels. On the other hand, it can stop the growth of new blood vessels, which is helpful for preventing the growth of metastatic tumors. It also helps regulate blood sugar and fat metabolism [R].
Decreased expression of this gene has been linked to type 2 diabetes [R].
Variants in ANGPTL4 have also been linked to [R, R, R, R, R]:
- Atherosclerosis
- Coronary artery disease
- Atherosclerotic stroke
- Breast cancer prognosis
- Blood triglycerides
- HDL cholesterol levels
Protein names
Recommended name:
Angiopoietin-related protein 4Short name:
HFARPAlternative name(s):
Angiopoietin-like protein 4Hepatic fibrinogen/angiopoietin-related protein
- RS1044250 (ANGPTL4) ??
- RS11672433 (ANGPTL4) ??
- RS116843064 (ANGPTL4) ??
- RS2278236 (ANGPTL4) ??
- RS7255436 (ANGPTL4) ??
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Top Gene-Substance Interactions
ANGPTL4 Interacts with These Diseases
| Disease | Score |
Substances That Increase ANGPTL4
| Substances | Interaction | Organism | Category |
Substances That Decrease ANGPTL4
| Substances | Interaction | Organism | Category |
Advanced Summary
Protein with hypoxia-induced expression in endothelial cells. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM).
The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
The encoded protein is induced by all PPARs.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Gene Pathways:
Molecular Function:
Biological Processes:
- Angiogenesis
- Response To Hypoxia
- Cell Differentiation
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Angiogenesis
- Negative Regulation Of Lipoprotein Lipase Activity
- Protein Homooligomerization
- Triglyceride Homeostasis
- Negative Regulation Of Endothelial Cell Apoptotic Process