Summary of ANGPTL4
This protein acts as survival and protective factor for vessel endothelial cells. Inhibits tumors (proliferation, migration) and reduces vascular leakage.
It functions as a hormone that regulates glucose and cholesterol balance, and insulin sensitivity.
Decreased expression of this gene has been associated with type 2 diabetes.
Protein names
Recommended name:
Angiopoietin-related protein 4Short name:
HFARPAlternative name(s):
Angiopoietin-like protein 4Hepatic fibrinogen/angiopoietin-related protein
- RS1044250 (ANGPTL4) ??
- RS11672433 (ANGPTL4) ??
- RS116843064 (ANGPTL4) ??
- RS2278236 (ANGPTL4) ??
- RS7255436 (ANGPTL4) ??
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Top Gene-Substance Interactions
ANGPTL4 Interacts with These Diseases
| Disease | Score |
Substances That Increase ANGPTL4
| Substances | Interaction | Organism | Category |
Substances That Decrease ANGPTL4
| Substances | Interaction | Organism | Category |
Advanced Summary
Protein with hypoxia-induced expression in endothelial cells. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM).
The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
The encoded protein is induced by all PPARs.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Gene Pathways:
Molecular Function:
Biological Processes:
- Angiogenesis
- Cell Differentiation
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Endothelial Cell Apoptotic Process
- Negative Regulation Of Lipoprotein Lipase Activity
- Positive Regulation Of Angiogenesis
- Protein Homooligomerization
- Response To Hypoxia
- Triglyceride Homeostasis