The Function of ALOX15
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
Protein names
Recommended name:
Arachidonate 15-lipoxygenaseShort name:
15-LOXAlternative name(s):
15-LOX-112/15-lipoxygenase
Arachidonate 12-lipoxygenase, leukocyte-type
12-LOX
Arachidonate omega-6 lipoxygenase
- RS2619112 (ALOX15) ??
- RS34210653 (ALOX15) ??
- RS916055 (ALOX15) ??
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Top Gene-Substance Interactions
ALOX15 Interacts with These Diseases
| Disease | Score |
Substances That Increase ALOX15
| Substances | Interaction | Organism | Category |
Substances That Decrease ALOX15
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
Induction:
Up-regulated by UV-irradiation.
Enzyme Regulation:
Activity is increased by binding phosphatidylinositol phosphates, especially phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Cofactor:
Binds 1 Fe cation per subunit.
Molecular Function:
- Arachidonate 12-Lipoxygenase Activity
- Arachidonate 15-Lipoxygenase Activity
- Eoxin A4 Synthase Activity
- Hepoxilin A3 Synthase Activity
- Hepoxilin-Epoxide Hydrolase Activity
- Iron Ion Binding
- Phosphatidylinositol-4,5-Bisphosphate Binding
Biological Processes:
- Apoptotic Cell Clearance
- Arachidonic Acid Metabolic Process
- Bone Mineralization
- Cellular Response To Calcium Ion
- Cellular Response To Interleukin-13
- Hepoxilin Biosynthetic Process
- Inflammatory Response
- Leukotriene Metabolic Process
- Lipoxin A4 Biosynthetic Process
- Lipoxygenase Pathway
- Negative Regulation Of Adaptive Immune Response
- Ossification
- Phosphatidylethanolamine Biosynthetic Process
- Positive Regulation Of Actin Filament Polymerization
- Positive Regulation Of Cell-Substrate Adhesion
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Heterotypic Cell-Cell Adhesion
- Regulation Of Engulfment Of Apoptotic Cell
- Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
- Response To Endoplasmic Reticulum Stress
- Wound Healing