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  3. ALOX15

ALOX15 (Arachidonate 15-lipoxygenase)

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The Function of ALOX15

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

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Protein names

Recommended name:

Arachidonate 15-lipoxygenase

Short name:

15-LOX

Alternative name(s):

15-LOX-1
12/15-lipoxygenase
Arachidonate 12-lipoxygenase, leukocyte-type
12-LOX
Arachidonate omega-6 lipoxygenase

ALOX15 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2619112 (ALOX15) ??
  2. RS34210653 (ALOX15) ??
  3. RS916055 (ALOX15) ??

Top Gene-Substance Interactions

ALOX15 Interacts with These Diseases

Disease Score

Substances That Increase ALOX15

Substances Interaction Organism Category

Substances That Decrease ALOX15

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Linoleic acid metabolism
  • Arachidonic acid metabolism

Induction:

Up-regulated by UV-irradiation.

Enzyme Regulation:

Activity is increased by binding phosphatidylinositol phosphates, especially phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.

Cofactor:

Binds 1 Fe cation per subunit.

Molecular Function:

  • Arachidonate 12-Lipoxygenase Activity
  • Arachidonate 15-Lipoxygenase Activity
  • Eoxin A4 Synthase Activity
  • Hepoxilin A3 Synthase Activity
  • Hepoxilin-Epoxide Hydrolase Activity
  • Iron Ion Binding
  • Phosphatidylinositol-4,5-Bisphosphate Binding

Biological Processes:

  • Apoptotic Cell Clearance
  • Arachidonic Acid Metabolic Process
  • Bone Mineralization
  • Cellular Response To Calcium Ion
  • Cellular Response To Interleukin-13
  • Hepoxilin Biosynthetic Process
  • Inflammatory Response
  • Leukotriene Metabolic Process
  • Lipoxin A4 Biosynthetic Process
  • Lipoxygenase Pathway
  • Negative Regulation Of Adaptive Immune Response
  • Ossification
  • Phosphatidylethanolamine Biosynthetic Process
  • Positive Regulation Of Actin Filament Polymerization
  • Positive Regulation Of Cell-Substrate Adhesion
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Heterotypic Cell-Cell Adhesion
  • Regulation Of Engulfment Of Apoptotic Cell
  • Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
  • Response To Endoplasmic Reticulum Stress
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

12-LO| 12-LOX| 12S-lipoxygenase| 12S-LOX| arachidonate 12-lipoxygenase| Arachidonate 12-lipoxygenase, 12S-type| 12/15-lipoxygenase| 12/15-LO| 12/15-LOX| 15-lipooxygenase-1| 15-LOX| 15-LOX-1| 15LOX-1| Alox12| Alox12e| Alox12l| Arachidonate 12-lipoxygenase, epidermal-type| arachidonate 12-lipoxygenase, leukocyte-type| arachidonate lipoxygenase, epidermal| arachidonate omega-6 lipoxygenase| CB1_000479012| erythroid cell-specific 15-lipoxygenase| H920_15676| I79_002784| L-12LO| lipoxygenase| LOX| MDA_GLEAN10004548| omega-6 lipoxygenase| PAL_GLEAN10010144| PANDA_013826| TREES_T100004057| alox15

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