Summary of ALOX12
This gene encodes a protein that regulates different biological processes including platelet activation. It also regulates the expression of the vascular endothelial growth factor, plays a role in cell death, and it may also play a role in the control of cell migration and proliferation (R).
The Function of ALOX12
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
Protein names
Recommended name:
Arachidonate 12-lipoxygenase, 12S-typeShort name:
12S-LOXAlternative name(s):
12S-lipoxygenaseLipoxin synthase 12-LO
Platelet-type lipoxygenase 12
- RS1126667 (ALOX12) ??
- RS2073438 (ALOX12) ??
- RS2292350 (ALOX12) ??
- RS434473 (ALOX12) ??
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Top Gene-Substance Interactions
ALOX12 Interacts with These Diseases
| Disease | Score |
Substances That Increase ALOX12
| Substances | Interaction | Organism | Category |
Substances That Decrease ALOX12
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in vascular smooth muscle cells.
Induction:
Down-regulated upon starvation, by UV-irradiation and 15-lipoxygenase metabolites.
Enzyme Regulation:
Activated by EGF.
Cofactor:
Binds 1 Fe cation per subunit.
Molecular Function:
- Arachidonate 12-Lipoxygenase Activity
- Hepoxilin A3 Synthase Activity
- Hepoxilin-Epoxide Hydrolase Activity
- Iron Ion Binding
- Linoleate 13s-Lipoxygenase Activity
- Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
Biological Processes:
- Aging
- Arachidonic Acid Metabolic Process
- Cellular Response To Lipid
- Establishment Of Skin Barrier
- Fatty Acid Oxidation
- Hepoxilin Biosynthetic Process
- Hepoxilin Metabolic Process
- Leukotriene A4 Metabolic Process
- Linoleic Acid Metabolic Process
- Lipoxin A4 Biosynthetic Process
- Lipoxin B4 Biosynthetic Process
- Lipoxin Metabolic Process
- Lipoxygenase Pathway
- Movement Of Cell Or Subcellular Component
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Muscle Cell Apoptotic Process
- Negative Regulation Of Platelet Aggregation
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Cell Adhesion
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Migration
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Positive Regulation Of Endothelial Cell Differentiation
- Positive Regulation Of Endothelial Cell Migration
- Positive Regulation Of Gene Expression
- Positive Regulation Of Mitochondrial Depolarization
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Vasodilation
- Reactive Oxygen Species Metabolic Process
- Superoxide Anion Generation