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  3. ALOX12

ALOX12 (Arachidonate 12-lipoxygenase, 12S type)

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Summary of ALOX12

This gene encodes a protein that regulates different biological processes including platelet activation. It also regulates the expression of the vascular endothelial growth factor, plays a role in cell death, and it may also play a role in the control of cell migration and proliferation (R).

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The Function of ALOX12

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.

Protein names

Recommended name:

Arachidonate 12-lipoxygenase, 12S-type

Short name:

12S-LOX

Alternative name(s):

12S-lipoxygenase
Lipoxin synthase 12-LO
Platelet-type lipoxygenase 12

ALOX12 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1126667 (ALOX12) ??
  2. RS2073438 (ALOX12) ??
  3. RS2292350 (ALOX12) ??
  4. RS434473 (ALOX12) ??

Top Gene-Substance Interactions

ALOX12 Interacts with These Diseases

Disease Score

Substances That Increase ALOX12

Substances Interaction Organism Category

Substances That Decrease ALOX12

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • Sp1

Tissue specificity:

Expressed in vascular smooth muscle cells.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Linoleic acid metabolism
  • Arachidonic acid metabolism

Induction:

Down-regulated upon starvation, by UV-irradiation and 15-lipoxygenase metabolites.

Enzyme Regulation:

Activated by EGF.

Cofactor:

Binds 1 Fe cation per subunit.

Molecular Function:

  • Arachidonate 12-Lipoxygenase Activity
  • Hepoxilin A3 Synthase Activity
  • Hepoxilin-Epoxide Hydrolase Activity
  • Iron Ion Binding
  • Linoleate 13s-Lipoxygenase Activity
  • Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen

Biological Processes:

  • Aging
  • Arachidonic Acid Metabolic Process
  • Cellular Response To Lipid
  • Establishment Of Skin Barrier
  • Fatty Acid Oxidation
  • Hepoxilin Biosynthetic Process
  • Hepoxilin Metabolic Process
  • Leukotriene A4 Metabolic Process
  • Linoleic Acid Metabolic Process
  • Lipoxin A4 Biosynthetic Process
  • Lipoxin B4 Biosynthetic Process
  • Lipoxin Metabolic Process
  • Lipoxygenase Pathway
  • Movement Of Cell Or Subcellular Component
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Muscle Cell Apoptotic Process
  • Negative Regulation Of Platelet Aggregation
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Cell Adhesion
  • Positive Regulation Of Cell Growth
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Positive Regulation Of Endothelial Cell Differentiation
  • Positive Regulation Of Endothelial Cell Migration
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Mitochondrial Depolarization
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Vasodilation
  • Reactive Oxygen Species Metabolic Process
  • Superoxide Anion Generation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 12-LO| 12-LOX| 12(S)-lipoxygenase| 12S-lipoxygenase| 12S-LOX| ALOX1| Alox12p| arachidonate 12-lipoxygenase| Arachidonate 12-lipoxygenase, 12S-type| arachidonate 15-lipoxygenase| GW7_07444| H920_15673| lipoxin synthase 12-LO| LOG12| LOX1| P-12LO| PAL_GLEAN10010147| PANDA_013827| platelet 12-LOX| platelet-type 12-lipoxygenase| platelet-type lipoxygenase 12| TREES_T100004062| alox12

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