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  3. ALDH7A1

ALDH7A1 (Aldehyde dehydrogenase 7 family member A1)

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The Function of ALDH7A1

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.

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Protein names

Recommended name:

Alpha-aminoadipic semialdehyde dehydrogenase

Alternative name(s):

Alpha-AASA dehydrogenase
Aldehyde dehydrogenase family 7 member A1
Antiquitin-1
Betaine aldehyde dehydrogenase
Delta1-piperideine-6-carboxylate dehydrogenase
P6c dehydrogenase

ALDH7A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13182402 (ALDH7A1) ??
  2. RS77885874 (ALDH7A1) ??

Top Gene-Substance Interactions

ALDH7A1 Interacts with These Diseases

Disease Score

Substances That Increase ALDH7A1

Substances Interaction Organism Category

Substances That Decrease ALDH7A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • GATA-3

Tissue specificity:

Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Fatty acid metabolism
  • Valine, leucine and isoleucine degradation
  • Lysine degradation
  • Tryptophan metabolism
  • Arginine and proline metabolism
  • Glycolysis / Gluconeogenesis
  • Glycine, serine and threonine metabolism
  • Pyruvate metabolism
  • Propanoate metabolism
  • Ascorbate and aldarate metabolism
  • beta-Alanine metabolism
  • Glycerolipid metabolism
  • Histidine metabolism
  • Lysine biosynthesis

Molecular Function:

  • Aldehyde Dehydrogenase (Nad) Activity
  • Betaine-Aldehyde Dehydrogenase Activity
  • L-Aminoadipate-Semialdehyde Dehydrogenase Activity

Biological Processes:

  • Cellular Aldehyde Metabolic Process
  • Choline Catabolic Process
  • Glycine Betaine Biosynthetic Process From Choline
  • Lysine Catabolic Process
  • Sensory Perception Of Sound
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 26g turgor protein homolog| A306_05969| al7a1| aldehyde dehydrogenase 7 family, member A1| aldehyde dehydrogenase family 7 member A1| aldehyde dehydrogenase family 7, member A1| aldehyde dehydrogenase family 7 member A1 homolog| aldehyde dehydrogenase family 7 member A1-like protein| alpha-AASA dehydrogenase| alpha-aminoadipic semialdehyde dehydrogenase| alpha-aminoadipic semialdehyde dehydrogenase-like isoform 2-like protein| Alpha-aminoadipic semialdehyde dehydrogenase-like protein| Anapl_15970| antiquitin| antiquitin-1| AS27_13777| AS28_14342| ATQ| Atq1| betaine aldehyde dehydrogenase| CB1_001532010| D18Wsu181e| delta1-piperideine-6-carboxylate dehydrogenase| delta1-piperideine-6-carboxylate dehydrogenease| EPD| GW7_15495| I79_003937| M959_03451| MDA_GLEAN10020667| N300_02279| N301_02927| N302_15708| N303_07906| N305_10202| N306_06856| N307_13353| N308_13687| N309_00858| N310_04137| N311_04534| N312_02839| N321_08226| N324_02039| N325_01998| N326_10736| N327_13173| N328_08113| N329_03706| N330_11250| N331_06223| N332_09266| N333_04389| N334_14284| N336_09886| N339_03937| N341_09590| P6c dehydrogenase| PAL_GLEAN10025100| PANDA_006523| PDE| TREES_T100006337| UY3_08066| Y1Q_004132| Y956_04715| Z169_11435| aldh7a1

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