The Function of ALDH7A1
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
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Protein names
Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenaseAlternative name(s):
Alpha-AASA dehydrogenaseAldehyde dehydrogenase family 7 member A1
Antiquitin-1
Betaine aldehyde dehydrogenase
Delta1-piperideine-6-carboxylate dehydrogenase
P6c dehydrogenase
- RS13182402 (ALDH7A1) ??
- RS77885874 (ALDH7A1) ??
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Top Gene-Substance Interactions
ALDH7A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ALDH7A1
| Substances | Interaction | Organism | Category |
Substances That Decrease ALDH7A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.
Gene Pathways:
- Metabolic pathways
- Metabolism
- Fatty acid metabolism
- Valine, leucine and isoleucine degradation
- Lysine degradation
- Tryptophan metabolism
- Arginine and proline metabolism
- Glycolysis / Gluconeogenesis
- Glycine, serine and threonine metabolism
- Pyruvate metabolism
- Propanoate metabolism
- Ascorbate and aldarate metabolism
- beta-Alanine metabolism
- Glycerolipid metabolism
- Histidine metabolism
- Lysine biosynthesis
Molecular Function:
- Aldehyde Dehydrogenase (Nad) Activity
- Betaine-Aldehyde Dehydrogenase Activity
- L-Aminoadipate-Semialdehyde Dehydrogenase Activity
Biological Processes:
- Cellular Aldehyde Metabolic Process
- Choline Catabolic Process
- Glycine Betaine Biosynthetic Process From Choline
- Lysine Catabolic Process
- Sensory Perception Of Sound