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  3. ALDH3A1

ALDH3A1 (Aldehyde dehydrogenase 3 family member A1)

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The Function of ALDH3A1

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light.

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Protein names

Recommended name:

Aldehyde dehydrogenase, dimeric NADP-preferring

Short name:

ALDHIII

Alternative name(s):

Aldehyde dehydrogenase 3
Aldehyde dehydrogenase family 3 member A1

Top Gene-Substance Interactions

Substances That Increase ALDH3A1

Substances Interaction Organism Category

Substances That Decrease ALDH3A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AhR
  • PPAR-alpha
  • C/EBPbeta
  • AML1a

Tissue specificity:

High levels in stomach, esophagus and lung; low level in the liver and kidney.

Molecular Function:

  • 3-Chloroallyl Aldehyde Dehydrogenase Activity
  • Alcohol Dehydrogenase (Nadp+) Activity
  • Aldehyde Dehydrogenase (Nad) Activity
  • Aldehyde Dehydrogenase
  • Benzaldehyde Dehydrogenase (Nad+) Activity
  • Aldehyde Dehydrogenase [Nad(P)+] Activity

Biological Processes:

  • Aging
  • Cellular Aldehyde Metabolic Process
  • Oxidation-Reduction Process
  • Positive Regulation Of Cell Proliferation
  • Response To Camp
  • Response To Glucocorticoid
  • Response To Hypoxia
  • Response To Nutrient
  • Xenobiotic Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Ahd4| Ahd-4| Ahd-c| AHDC| alcohol dehydrogenase family 3, subfamily A1| aldehyde dehydrogenase 3A1| aldehyde dehydrogenase 3 family, memberA1| aldehyde dehydrogenase 3 family, member A1| aldehyde dehydrogenase 3, stomach cytosolic (class 3)| aldehyde dehydrogenase 4| Aldehyde dehydrogenase (Ahd-c)| aldehyde dehydrogenase class 3| aldehyde dehydrogenase, dimeric NADP-preferring| aldehyde dehydrogenase family 3 member A1| aldehyde dehydrogenase family 3 subfamily A1| aldehyde dehydrogenase family 3, subfamily A1| aldehyde dehydrogenase isozyme 3| aldehyde dehydrogenase type III| Aldh| Aldh3| ALDHIII| BCP54| corneal 15.8 kDa protein| corneal protein 54, transparentin| D623_10023257| dehydrogenase 3, dimeric NAPD-prefering| dioxin-inducible aldehyde dehydrogenase 3| HTC-ALDH| M91_01726| Multidrug and toxin extrusion protein 2| PAL_GLEAN10008598| PANDA_009717| stomach aldehyde dehydrogenase| transparentin| TREES_T100007801| tumor-associated aldehyde dehydrogenase tumor ALDH| aldh3a1

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