The Function of ALDH3A1
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light.
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Protein names
Recommended name:
Aldehyde dehydrogenase, dimeric NADP-preferringShort name:
ALDHIIIAlternative name(s):
Aldehyde dehydrogenase 3Aldehyde dehydrogenase family 3 member A1
Top Gene-Substance Interactions
Substances That Increase ALDH3A1
| Substances | Interaction | Organism | Category |
Substances That Decrease ALDH3A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
High levels in stomach, esophagus and lung; low level in the liver and kidney.
Molecular Function:
- 3-Chloroallyl Aldehyde Dehydrogenase Activity
- Alcohol Dehydrogenase (Nadp+) Activity
- Aldehyde Dehydrogenase (Nad) Activity
- Aldehyde Dehydrogenase
- Benzaldehyde Dehydrogenase (Nad+) Activity
- Aldehyde Dehydrogenase [Nad(P)+] Activity
Biological Processes:
- Aging
- Cellular Aldehyde Metabolic Process
- Oxidation-Reduction Process
- Positive Regulation Of Cell Proliferation
- Response To Camp
- Response To Glucocorticoid
- Response To Hypoxia
- Response To Nutrient
- Xenobiotic Metabolic Process