The Function of ALDH1A1
Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.
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Protein names
Recommended name:
Retinal dehydrogenase 1Alternative name(s):
RALDH 1RalDH1
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A1
Aldehyde dehydrogenase, cytosolic
- RS610529 (ALDH1A1) ??
- RS8187974 (ALDH1A1) ??
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Top Gene-Substance Interactions
ALDH1A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ALDH1A1
| Substances | Interaction | Organism | Category |
Substances That Decrease ALDH1A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Metabolic pathways
- Metabolism
- Fatty acid metabolism
- Valine, leucine and isoleucine degradation
- Lysine degradation
- Tryptophan metabolism
- Arginine and proline metabolism
- Glycolysis / Gluconeogenesis
- Retinol metabolism
- Pyruvate metabolism
- Propanoate metabolism
- Ascorbate and aldarate metabolism
- Pentose and glucuronate interconversions
- beta-Alanine metabolism
- Glycerolipid metabolism
- Histidine metabolism
Molecular Function:
- Retinal Dehydrogenase Activity
- Aldehyde Dehydrogenase (Nad) Activity
- Gtpase Activator Activity
- Androgen Binding
- Benzaldehyde Dehydrogenase (Nad+) Activity
Biological Processes:
- Ethanol Oxidation
- Cellular Aldehyde Metabolic Process
- Retinol Metabolic Process
- Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-Phosphate