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  3. ALDH1A1

ALDH1A1 (Aldehyde dehydrogenase 1 family member A1)

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The Function of ALDH1A1

Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.

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Protein names

Recommended name:

Retinal dehydrogenase 1

Alternative name(s):

RALDH 1
RalDH1
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A1
Aldehyde dehydrogenase, cytosolic

ALDH1A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS610529 (ALDH1A1) ??
  2. RS8187974 (ALDH1A1) ??

Top Gene-Substance Interactions

ALDH1A1 Interacts with These Diseases

Disease Score

Substances That Increase ALDH1A1

Substances Interaction Organism Category

Substances That Decrease ALDH1A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Fatty acid metabolism
  • Valine, leucine and isoleucine degradation
  • Lysine degradation
  • Tryptophan metabolism
  • Arginine and proline metabolism
  • Glycolysis / Gluconeogenesis
  • Retinol metabolism
  • Pyruvate metabolism
  • Propanoate metabolism
  • Ascorbate and aldarate metabolism
  • Pentose and glucuronate interconversions
  • beta-Alanine metabolism
  • Glycerolipid metabolism
  • Histidine metabolism

Molecular Function:

  • Aldehyde Dehydrogenase (Nad) Activity
  • Androgen Binding
  • Benzaldehyde Dehydrogenase (Nad+) Activity
  • Gtpase Activator Activity
  • Retinal Dehydrogenase Activity

Biological Processes:

  • Cellular Aldehyde Metabolic Process
  • Ethanol Oxidation
  • Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-Phosphate
  • Retinol Metabolic Process

Drug Bank:

  • Vitamin A
  • Tretinoin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| acetaldehyde dehydrogenase 1| Ahd2| Ahd-2| AL1A1| alcohol dehydrogenase family 1, subfamily A1| alcohol dehydrogenase family 1, subfamily A2| aldc| ALDDH| aldehyde dehydrogenase 1A1| aldehyde dehydrogenase 1 family, member A1| aldehyde dehydrogenase 1, liver cytosolic (class 1)| aldehyde dehydrogenase 1, soluble| aldehyde dehydrogenase 1, subfamily A1| aldehyde dehydrogenase 2| aldehyde dehydrogenase, cytosolic| aldehyde dehydrogenase family 1 member A1| aldehyde dehydrogenase family 1, subfamily A1| aldehyde dehydrogenase, liver cytosolic| ALDH1| aldh11| Aldh1a2| Aldh2| ALDH class 1| ALDH-E1| ALHDII| AS27_02946| AS28_10928| CB1_002439005| chromosome 1 GSS clone AHT1-34| cytosolic aldehyde dehydrogenase| E1| EGK_07786| epididymis luminal protein 12| epididymis luminal protein 9| epididymis secretory sperm binding protein Li 53e| GGADHR| GW7_17324| HEL12| HEL-9| HEL-S-53e| M959_12115| MDA_GLEAN10017981| N300_09205| N301_11845| N302_05742| N303_10042| N305_12182| N306_02605| N307_01398| N308_10423| N309_04100| N311_11681| N320_00106| N322_01846| N324_01815| N327_10218| N328_11036| N329_12277| N333_02717| N335_08248| N336_01467| N339_05994| N340_05570| PAL_GLEAN10021094| PUMB1| RALDH1| RALDH 1| retinaldehyde dehydrogenase 1| retinal dehydrogenase 1| UY3_12434| Y1Q_027482| Y956_14685| Z169_08590| aldh1a1

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