Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• GATA-1
• AML1a

Tissue specificity:

Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).

Induction:

Up-regulated by TNF and IFNG (at protein level).

Molecular Function:

• Receptor Binding

Biological Processes:

• Adaptive Immune Response
• Axon Extension Involved In Axon Guidance
• Cell Adhesion
• Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
• Motor Neuron Axon Guidance
• Neuron Projection Extension
• Retinal Ganglion Cell Axon Guidance
• Signal Transduction

*synonyms