The Function of ALCAM
Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.
Protein names
Recommended name:
CD166 antigenAlternative name(s):
Activated leukocyte cell adhesion moleculeCD antigen CD166
- RS138904061 (ALCAM) ??
- RS9810233 (ALCAM) ??
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Top Gene-Substance Interactions
ALCAM Interacts with These Diseases
Disease | Score |
Substances That Increase ALCAM
Substances | Interaction | Organism | Category |
Substances That Decrease ALCAM
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).
Gene Pathways:
Induction:
Up-regulated by TNF and IFNG (at protein level).
Molecular Function:
Biological Processes:
- Adaptive Immune Response
- Axon Extension Involved In Axon Guidance
- Cell Adhesion
- Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
- Motor Neuron Axon Guidance
- Neuron Projection Extension
- Retinal Ganglion Cell Axon Guidance
- Signal Transduction