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  3. ALCAM

ALCAM (Activated leukocyte cell adhesion molecule)

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The Function of ALCAM

Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.

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Protein names

Recommended name:

CD166 antigen

Alternative name(s):

Activated leukocyte cell adhesion molecule
CD antigen CD166

ALCAM SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS138904061 (ALCAM) ??
  2. RS9810233 (ALCAM) ??

Top Gene-Substance Interactions

ALCAM Interacts with These Diseases

Disease Score

Substances That Increase ALCAM

Substances Interaction Organism Category

Substances That Decrease ALCAM

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GATA-1
  • AML1a

Tissue specificity:

Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).

Gene Pathways:

  • Cell adhesion molecules (CAMs)

Induction:

Up-regulated by TNF and IFNG (at protein level).

Molecular Function:

  • Receptor Binding

Biological Processes:

  • Adaptive Immune Response
  • Axon Extension Involved In Axon Guidance
  • Cell Adhesion
  • Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
  • Motor Neuron Axon Guidance
  • Neuron Projection Extension
  • Retinal Ganglion Cell Axon Guidance
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_10393| activated leucocyte cell adhesion molecule| AS27_06602| AS28_08827| BEN| BEN glycoprotein| CB1_001399005| cd166| CD166 antigen| CD166 antigen homolog| D623_10011828| DM-GRASP| DM-GRASP II| H920_15731| HB2| JC7| KG-CAM| M91_05498| M959_00344| MDA_GLEAN10009430| MEMD| MuSC| N300_14432| N301_12669| N302_07965| N303_09601| N305_06396| N306_09848| N307_01687| N308_09707| N309_09083| N310_00371| N311_01657| N312_04307| N321_09583| N322_12641| N324_00369| N325_11269| N326_00682| N328_12208| N329_12974| N330_14207| N331_00756| N332_06182| N333_12534| N334_03782| N335_13292| N336_06560| N339_01142| N340_06120| neurolin-a| PAL_GLEAN10013341| PANDA_004164| SB-10 antigen| SC1| SC1 glycoprotein| TREES_T100011727| Y1Q_016233| Y956_09466| Z169_08893| alcam

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