The Function of AKR1C3
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Protein names
Recommended name:
Aldo-keto reductase family 1 member C3Short name:
DD3Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 517-beta-HSD 5
3-alpha-HSD type II, brain
3-alpha-hydroxysteroid dehydrogenase type 2
3-alpha-HSD type 2
Chlordecone reductase homolog HAKRb
Dihydrodiol dehydrogenase 3
DD-3
Dihydrodiol dehydrogenase type I
HA1753
Indanol dehydrogenase
Prostaglandin F synthase
PGFS
Testosterone 17-beta-dehydrogenase 5
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- RS1937920 (AKR1C3) ??
- RS2518049 (AKR1C3) ??
- RS536477 (AKR1C3) ??
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Top Gene-Substance Interactions
AKR1C3 Interacts with These Diseases
| Disease | Score |
Substances That Increase AKR1C3
| Substances | Interaction | Organism | Category |
Substances That Decrease AKR1C3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Gene Pathways:
Enzyme Regulation:
Strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. Also inhibited by the flavinoid, rutin, and by selective serotonin inhibitors (SSRIs).
Molecular Function:
- 15-Hydroxyprostaglandin-D Dehydrogenase (Nadp+) Activity
- Alditol:Nadp+ 1-Oxidoreductase Activity
- Aldo-Keto Reductase (Nadp) Activity
- Androsterone Dehydrogenase Activity
- Delta4-3-Oxosteroid 5beta-Reductase Activity
- Dihydrotestosterone 17-Beta-Dehydrogenase Activity
- Geranylgeranyl Reductase Activity
- Indanol Dehydrogenase Activity
- Ketoreductase Activity
- Ketosteroid Monooxygenase Activity
- Nadp-Retinol Dehydrogenase Activity
- Oxidoreductase Activity, Acting On Nad(P)H, Quinone Or Similar Compound As Acceptor
- Phenanthrene 9,10-Monooxygenase Activity
- Prostaglandin D2 11-Ketoreductase Activity
- Prostaglandin-F Synthase Activity
- Prostaglandin H2 Endoperoxidase Reductase Activity
- Retinal Dehydrogenase Activity
- Retinol Dehydrogenase Activity
- Testosterone 17-Beta-Dehydrogenase (Nadp+) Activity
- Testosterone Dehydrogenase (Nad+) Activity
- Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase Activity
Biological Processes:
- Cellular Response To Cadmium Ion
- Cellular Response To Calcium Ion
- Cellular Response To Corticosteroid Stimulus
- Cellular Response To Jasmonic Acid Stimulus
- Cellular Response To Prostaglandin D Stimulus
- Cellular Response To Prostaglandin Stimulus
- Cellular Response To Reactive Oxygen Species
- Cellular Response To Starvation
- Cyclooxygenase Pathway
- Daunorubicin Metabolic Process
- Doxorubicin Metabolic Process
- Farnesol Catabolic Process
- G-Protein Coupled Receptor Signaling Pathway
- Keratinocyte Differentiation
- Male Gonad Development
- Multicellular Organismal Macromolecule Metabolic Process
- Negative Regulation Of Retinoic Acid Biosynthetic Process
- Oxidation-Reduction Process
- Positive Regulation Of Cell Death
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Endothelial Cell Apoptotic Process
- Positive Regulation Of Protein Kinase B Signaling
- Positive Regulation Of Reactive Oxygen Species Metabolic Process
- Progesterone Metabolic Process
- Prostaglandin Metabolic Process
- Protein Import Into Nucleus, Translocation
- Regulation Of Retinoic Acid Receptor Signaling Pathway
- Regulation Of Testosterone Biosynthetic Process
- Renal Absorption
- Response To Nutrient
- Retinal Metabolic Process
- Retinoid Metabolic Process
- Steroid Metabolic Process
- Testosterone Biosynthetic Process