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  3. AKR1C3

AKR1C3 (Aldo-keto reductase family 1 member C3)

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The Function of AKR1C3

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

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Protein names

Recommended name:

Aldo-keto reductase family 1 member C3

Short name:

DD3

Alternative name(s):

17-beta-hydroxysteroid dehydrogenase type 5
17-beta-HSD 5
3-alpha-HSD type II, brain
3-alpha-hydroxysteroid dehydrogenase type 2
3-alpha-HSD type 2
Chlordecone reductase homolog HAKRb
Dihydrodiol dehydrogenase 3
DD-3
Dihydrodiol dehydrogenase type I
HA1753
Indanol dehydrogenase
Prostaglandin F synthase
PGFS
Testosterone 17-beta-dehydrogenase 5
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

AKR1C3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1937920 (AKR1C3) ??
  2. RS2518049 (AKR1C3) ??
  3. RS536477 (AKR1C3) ??

Top Gene-Substance Interactions

AKR1C3 Interacts with These Diseases

Disease Score

Substances That Increase AKR1C3

Substances Interaction Organism Category

Substances That Decrease AKR1C3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Sp1

Tissue specificity:

Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.

Gene Pathways:

  • Metabolism
  • Steroid hormone biosynthesis
  • Disease
  • Signal Transduction
  • Metabolism of xenobiotics by cytochrome P450
  • Arachidonic acid metabolism

Enzyme Regulation:

Strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. Also inhibited by the flavinoid, rutin, and by selective serotonin inhibitors (SSRIs).

Molecular Function:

  • 15-Hydroxyprostaglandin-D Dehydrogenase (Nadp+) Activity
  • Alditol:Nadp+ 1-Oxidoreductase Activity
  • Aldo-Keto Reductase (Nadp) Activity
  • Androsterone Dehydrogenase Activity
  • Delta4-3-Oxosteroid 5beta-Reductase Activity
  • Dihydrotestosterone 17-Beta-Dehydrogenase Activity
  • Geranylgeranyl Reductase Activity
  • Indanol Dehydrogenase Activity
  • Ketoreductase Activity
  • Ketosteroid Monooxygenase Activity
  • Nadp-Retinol Dehydrogenase Activity
  • Oxidoreductase Activity, Acting On Nad(P)H, Quinone Or Similar Compound As Acceptor
  • Phenanthrene 9,10-Monooxygenase Activity
  • Prostaglandin D2 11-Ketoreductase Activity
  • Prostaglandin-F Synthase Activity
  • Prostaglandin H2 Endoperoxidase Reductase Activity
  • Retinal Dehydrogenase Activity
  • Retinol Dehydrogenase Activity
  • Testosterone 17-Beta-Dehydrogenase (Nadp+) Activity
  • Testosterone Dehydrogenase (Nad+) Activity
  • Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase Activity

Biological Processes:

  • Cellular Response To Cadmium Ion
  • Cellular Response To Calcium Ion
  • Cellular Response To Corticosteroid Stimulus
  • Cellular Response To Jasmonic Acid Stimulus
  • Cellular Response To Prostaglandin D Stimulus
  • Cellular Response To Prostaglandin Stimulus
  • Cellular Response To Reactive Oxygen Species
  • Cellular Response To Starvation
  • Cyclooxygenase Pathway
  • Daunorubicin Metabolic Process
  • Doxorubicin Metabolic Process
  • Farnesol Catabolic Process
  • G-Protein Coupled Receptor Signaling Pathway
  • Keratinocyte Differentiation
  • Male Gonad Development
  • Multicellular Organismal Macromolecule Metabolic Process
  • Negative Regulation Of Retinoic Acid Biosynthetic Process
  • Oxidation-Reduction Process
  • Positive Regulation Of Cell Death
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Endothelial Cell Apoptotic Process
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Progesterone Metabolic Process
  • Prostaglandin Metabolic Process
  • Protein Import Into Nucleus, Translocation
  • Regulation Of Retinoic Acid Receptor Signaling Pathway
  • Regulation Of Testosterone Biosynthetic Process
  • Renal Absorption
  • Response To Nutrient
  • Retinal Metabolic Process
  • Retinoid Metabolic Process
  • Steroid Metabolic Process
  • Testosterone Biosynthetic Process

Drug Bank:

  • Doxorubicin
  • Bimatoprost
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 20-alpha-HSD| 20-alpha-hydroxysteroid dehydrogenase| aldo-keto reductase family 1 member C3 homolog| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase| 17-beta-HSD 5| 17-beta-hydroxysteroid dehydrogenase type 5| 20alpha-hydroxysteroid dehydrogenase| 3-alpha-HSD type 2| 3-alpha-HSD type II, brain| 3-alpha-hydroxysteroid dehydrogenase| 3-alpha-hydroxysteroid dehydrogenase type 2| 3-alpha hydroxysteroid dehydrogenase, type II| Akr1c18| aldo-keto reductase family 1 member C18| aldo-keto reductase family 1, member C18| aldo-keto reductase family 1 member C21| aldo-keto reductase family 1, member C3| aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)| chlordecone reductase homolog HAKRb| DD3| DDX| dihydrodiol dehydrogenase 3| dihydrodiol dehydrogenase X| HA1753| HAKRB| HAKRe| hluPGFS| HSD1| HSD17B5| indanol dehydrogenase| PGFS| prostaglandin F synthase| testosterone 17-beta-dehydrogenase 5| type IIb 3-alpha hydroxysteroid dehydrogenase| akr1c3

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