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  3. AKR1C1

AKR1C1 (Aldo-keto reductase family 1 member C1)

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The Function of AKR1C1

Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.

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Protein names

Recommended name:

Aldo-keto reductase family 1 member C1

Short name:

HBAB

Alternative name(s):

20-alpha-hydroxysteroid dehydrogenase
20-alpha-HSD
Chlordecone reductase homolog HAKRC
Dihydrodiol dehydrogenase 1/2
DD1/DD2
High-affinity hepatic bile acid-binding protein
Indanol dehydrogenase
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

AKR1C1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2904804 (AKR1C1) ??
  2. RS4332428 (AKR1C1) ??

Top Gene-Substance Interactions

AKR1C1 Interacts with These Diseases

Disease Score

Substances That Increase AKR1C1

Substances Interaction Organism Category

Substances That Decrease AKR1C1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.

Gene Pathways:

  • Metabolism
  • Steroid hormone biosynthesis
  • Disease
  • Signal Transduction
  • Metabolism of xenobiotics by cytochrome P450

Enzyme Regulation:

Inhibited by hexestrol with an IC(50) of 9.5 uM, 1,10-phenanthroline with an IC(50) of 55 uM, 1,7-phenanthroline with an IC(50) of 72 uM, flufenamic acid with an IC(50) of 6.0 uM, indomethacin with an IC(50) of 140 uM, ibuprofen with an IC(50) of 950 uM, lithocholic acid with an IC(50) of 25 uM, ursodeoxycholic acid with an IC(50) of 340 uM and chenodeoxycholic acid with an IC(50) of 570 uM.

Molecular Function:

  • 17-Alpha,20-Alpha-Dihydroxypregn-4-En-3-One Dehydrogenase Activity
  • Alditol:Nadp+ 1-Oxidoreductase Activity
  • Aldo-Keto Reductase (Nadp) Activity
  • Androsterone Dehydrogenase (B-Specific) Activity
  • Bile Acid Binding
  • Carboxylic Acid Binding
  • Indanol Dehydrogenase Activity
  • Ketosteroid Monooxygenase Activity
  • Oxidoreductase Activity, Acting On Nad(P)H, Quinone Or Similar Compound As Acceptor
  • Phenanthrene 9,10-Monooxygenase Activity
  • Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase Activity

Biological Processes:

  • Bile Acid And Bile Salt Transport
  • Bile Acid Metabolic Process
  • Cellular Response To Jasmonic Acid Stimulus
  • Cholesterol Homeostasis
  • Daunorubicin Metabolic Process
  • Digestion
  • Doxorubicin Metabolic Process
  • Epithelial Cell Differentiation
  • Intestinal Cholesterol Absorption
  • Oxidation-Reduction Process
  • Progesterone Metabolic Process
  • Protein Homooligomerization
  • Response To Organophosphorus
  • Retinal Metabolic Process
  • Retinoid Metabolic Process
  • Xenobiotic Metabolic Process

Drug Bank:

  • Acetylsalicylic Acid
  • Salicylic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

20-alpha-hydroxysteroid dehydrogenase| akr1c1| aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)| dd1| ddh1| hakrc| mbab| 17beta hydroxysteroid dehydrogenase type 5| 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)| 20-ALPHA-HSD| 20 alpha-hydroxysteroid dehydrogenase| 2-ALPHA-HSD| 3(20)alpha-hydroxysteroid/dihydrodiol/indanol dehydrogenase| AKR1C23| Akr1c6| aldo-keto reductase C| aldo-keto reductase family 1 C1| aldo-keto reductase family 1, member C1| aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1| aldo-keto reductase family 1 member C1 homolog| aldo-keto reductase family 1 member C1-like| aldo-keto reductase family 1 member C23| aldo-keto reductase family 1 member C3 homolog| aldo-keto reductase family 1, member C6| aldo-keto reductase family 1 members C1 and C2-like protein| C9| chlordecone reductase homolog HAKRC| dd-1| DD1/DD2| DDH| Dihydrodiol dehydrogenase 1| dihydrodiol dehydrogenase 1/2| dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase| dihydrodiol dehydrogenase isoform DD1| H-37| HBAB| hepatic dihydrodiol dehydrogenase| high-affinity hepatic bile acid-binding protein| Hsd17b5| Indanol dehydrogenase| putative aldo-keto reductase family 1 member C1| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase| type 5 17beta-hydroxysteroid dehydrogenase| type II 3-alpha-hydroxysteroid dehydrogenase

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