The Function of AKR1C1
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Protein names
Recommended name:
Aldo-keto reductase family 1 member C1Short name:
HBABAlternative name(s):
20-alpha-hydroxysteroid dehydrogenase20-alpha-HSD
Chlordecone reductase homolog HAKRC
Dihydrodiol dehydrogenase 1/2
DD1/DD2
High-affinity hepatic bile acid-binding protein
Indanol dehydrogenase
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- RS2904804 (AKR1C1) ??
- RS4332428 (AKR1C1) ??
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Top Gene-Substance Interactions
AKR1C1 Interacts with These Diseases
| Disease | Score |
Substances That Increase AKR1C1
| Substances | Interaction | Organism | Category |
Substances That Decrease AKR1C1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Gene Pathways:
Enzyme Regulation:
Inhibited by hexestrol with an IC(50) of 9.5 uM, 1,10-phenanthroline with an IC(50) of 55 uM, 1,7-phenanthroline with an IC(50) of 72 uM, flufenamic acid with an IC(50) of 6.0 uM, indomethacin with an IC(50) of 140 uM, ibuprofen with an IC(50) of 950 uM, lithocholic acid with an IC(50) of 25 uM, ursodeoxycholic acid with an IC(50) of 340 uM and chenodeoxycholic acid with an IC(50) of 570 uM.
Molecular Function:
- 17-Alpha,20-Alpha-Dihydroxypregn-4-En-3-One Dehydrogenase Activity
- Alditol:Nadp+ 1-Oxidoreductase Activity
- Aldo-Keto Reductase (Nadp) Activity
- Androsterone Dehydrogenase (B-Specific) Activity
- Bile Acid Binding
- Carboxylic Acid Binding
- Indanol Dehydrogenase Activity
- Ketosteroid Monooxygenase Activity
- Oxidoreductase Activity, Acting On Nad(P)H, Quinone Or Similar Compound As Acceptor
- Phenanthrene 9,10-Monooxygenase Activity
- Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase Activity
Biological Processes:
- Bile Acid And Bile Salt Transport
- Bile Acid Metabolic Process
- Cellular Response To Jasmonic Acid Stimulus
- Cholesterol Homeostasis
- Daunorubicin Metabolic Process
- Digestion
- Doxorubicin Metabolic Process
- Epithelial Cell Differentiation
- Intestinal Cholesterol Absorption
- Oxidation-Reduction Process
- Progesterone Metabolic Process
- Protein Homooligomerization
- Response To Organophosphorus
- Retinal Metabolic Process
- Retinoid Metabolic Process
- Xenobiotic Metabolic Process
Drug Bank:
- Acetylsalicylic Acid
- Salicylic Acid