The Function of AKR1B1
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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Protein names
Recommended name:
Aldose reductaseShort name:
ARAlternative name(s):
Aldehyde reductaseAldo-keto reductase family 1 member B1
- RS759853 (AKR1B1) ??
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Top Gene-Substance Interactions
AKR1B1 Interacts with These Diseases
| Disease | Score |
Substances That Increase AKR1B1
| Substances | Interaction | Organism | Category |
Substances That Decrease AKR1B1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
Gene Pathways:
Enzyme Regulation:
Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis.
Molecular Function:
- Alditol:Nadp+ 1-Oxidoreductase Activity
- Aldo-Keto Reductase (Nadp) Activity
- Electron Carrier Activity
- Glyceraldehyde Oxidoreductase Activity
Biological Processes:
- C21-Steroid Hormone Biosynthetic Process
- Carbohydrate Metabolic Process
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Methylglyoxal
- Cellular Response To Peptide
- Daunorubicin Metabolic Process
- Doxorubicin Metabolic Process
- Fructose Biosynthetic Process
- Inner Medullary Collecting Duct Development
- Maternal Process Involved In Female Pregnancy
- Naphthalene Metabolic Process
- Norepinephrine Metabolic Process
- Positive Regulation Of Jak-Stat Cascade
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Response To Stress
- Response To Thyroid Hormone
- Response To Water Deprivation
- Sorbitol Biosynthetic Process
- Stress-Activated Protein Kinase Signaling Cascade
- Tissue Homeostasis