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  3. AKR1B1

AKR1B1 (Aldo-keto reductase family 1 member B)

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The Function of AKR1B1

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

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Protein names

Recommended name:

Aldose reductase

Short name:

AR

Alternative name(s):

Aldehyde reductase
Aldo-keto reductase family 1 member B1

AKR1B1 SNPs

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  1. RS759853 (AKR1B1) ??

Top Gene-Substance Interactions

AKR1B1 Interacts with These Diseases

Disease Score

Substances That Increase AKR1B1

Substances Interaction Organism Category

Substances That Decrease AKR1B1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • AP-1
  • c-Jun
  • C/EBPbeta
  • STAT5A
  • Sp1

Tissue specificity:

Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormones
  • Fructose and mannose metabolism
  • Pyruvate metabolism
  • Galactose metabolism
  • Pentose and glucuronate interconversions
  • Glycerolipid metabolism

Enzyme Regulation:

Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis.

Molecular Function:

  • Alditol:Nadp+ 1-Oxidoreductase Activity
  • Aldo-Keto Reductase (Nadp) Activity
  • Electron Carrier Activity
  • Glyceraldehyde Oxidoreductase Activity

Biological Processes:

  • C21-Steroid Hormone Biosynthetic Process
  • Carbohydrate Metabolic Process
  • Cellular Response To Hydrogen Peroxide
  • Cellular Response To Methylglyoxal
  • Cellular Response To Peptide
  • Daunorubicin Metabolic Process
  • Doxorubicin Metabolic Process
  • Fructose Biosynthetic Process
  • Inner Medullary Collecting Duct Development
  • Maternal Process Involved In Female Pregnancy
  • Naphthalene Metabolic Process
  • Norepinephrine Metabolic Process
  • Positive Regulation Of Jak-Stat Cascade
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Response To Stress
  • Response To Thyroid Hormone
  • Response To Water Deprivation
  • Sorbitol Biosynthetic Process
  • Stress-Activated Protein Kinase Signaling Cascade
  • Tissue Homeostasis

Drug Bank:

  • Sulindac
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| aldehyde reductase| 20-alpha-HSD| 20-alpha-hydroxysteroid dehydrogenase| 20-alpha hydroxysteroid dehydrogenase protein| ADR| Akr1b3| Akr1b4| akr1b7| aldehyde reductase 1| Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)| aldoketoreductase 1B5| aldo-keto reductase family 1 member B1| aldo-keto reductase family 1, member B1| aldo-keto reductase family 1 member B10| aldo-keto reductase family 1, member B10 (aldose reductase)| aldo-keto reductase family 1, member B1 (aldose reductase)| aldo-keto reductase family 1, member B4 (aldose reductase)| aldo-keto reductase family 1, member B7| aldose reductase| aldose reductase-like protein| aldr| ALDR1| ALDRED| Alr| ALR2| ALR-P-I| AR| CB1_002312009| D623_10009064| EGK_14153| GW7_05923| H920_17221| Lii5-2 CTCL tumor antigen| low Km aldose reductase| M91_10134| MDA_GLEAN10011583| N305_11547| N310_08997| N336_01990| N340_12256| PAL_GLEAN10019113| PANDA_017336| RATALDRED| akr1b1

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