The Function of AKAP1
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
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Protein names
Recommended name:
A-kinase anchor protein 1, mitochondrialShort name:
PRKA1Alternative name(s):
A-kinase anchor protein 149 kDaAKAP 149
Dual specificity A-kinase-anchoring protein 1
D-AKAP-1
Protein kinase A-anchoring protein 1
Spermatid A-kinase anchor protein 84
S-AKAP84
Top Gene-Substance Interactions
AKAP1 Interacts with These Diseases
| Disease | Score |
Substances That Increase AKAP1
| Substances | Interaction | Organism | Category |
Substances That Decrease AKAP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250).
Gene Pathways:
Molecular Function:
Biological Processes:
- Blood Coagulation
- Regulation Of Protein Kinase A Signaling
- Cellular Response To Camp
- Cellular Response To Peptide Hormone Stimulus
- Negative Regulation Of Cardiac Muscle Hypertrophy
- Negative Regulation Of Nfat Protein Import Into Nucleus
- Negative Regulation Of Protein Dephosphorylation