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  3. AKAP1

AKAP1 (A-kinase anchoring protein 1)

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The Function of AKAP1

Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.

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Protein names

Recommended name:

A-kinase anchor protein 1, mitochondrial

Short name:

PRKA1

Alternative name(s):

A-kinase anchor protein 149 kDa
AKAP 149
Dual specificity A-kinase-anchoring protein 1
D-AKAP-1
Protein kinase A-anchoring protein 1
Spermatid A-kinase anchor protein 84
S-AKAP84

Top Gene-Substance Interactions

AKAP1 Interacts with These Diseases

Disease Score

Substances That Increase AKAP1

Substances Interaction Organism Category

Substances That Decrease AKAP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • c-Myc
  • Sox9

Tissue specificity:

Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250).

Gene Pathways:

  • Hemostasis

Molecular Function:

  • Poly(A) Rna Binding
  • Protein Kinase A Regulatory Subunit Binding
  • Rna Binding

Biological Processes:

  • Blood Coagulation
  • Regulation Of Protein Kinase A Signaling
  • Cellular Response To Camp
  • Cellular Response To Peptide Hormone Stimulus
  • Negative Regulation Of Cardiac Muscle Hypertrophy
  • Negative Regulation Of Nfat Protein Import Into Nucleus
  • Negative Regulation Of Protein Dephosphorylation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_02091| AKAP| AKAP121| AKAP 121| AKAP149| AKAP 149| akap84| A-kinase anchor protein 1| A-kinase anchor protein 121 kDa| A-kinase anchor protein 149 kDa| a-kinase anchor protein 1, mitochondrial| A kinase anchor protein 1, mitochondrial| A-kinase-anchor-protein 84| A kinase (PRKA) anchor protein 1| AS27_13547| AS28_09413| C76494| C81186| CB1_000552011| D623_10020688| DAKAP1| D-AKAP1| D-AKAP-1| dual specificity A-kinase-anchoring protein 1| dual-specificity A-kinase anchoring protein 1| EGK_08562| H920_03702| I79_003961| M91_01204| M959_13448| MDA_GLEAN10007865| N300_14078| N301_08124| N302_07665| N303_14603| N305_07205| N307_12387| N308_14348| N310_05115| N311_02331| N312_12804| N320_05368| N321_02282| N324_02159| N327_12328| N330_08234| N331_09758| N333_06428| N334_12722| N335_13282| N336_04298| N341_12190| PAL_GLEAN10019764| PANDA_003687| PPP1R43| PRKA1| protein kinase A1| protein kinase A anchoring protein 1| protein kinase A-anchoring protein 1| protein phosphatase 1, regulatory subunit 43| S-AKAP| SAKAP84| S-AKAP84| spermatid A-kinase anchor protein| spermatid A-kinase anchor protein 84| TDRD17| testicular secretory protein Li 5| TREES_T100015090| tudor domain containing 17| Y1Q_016137| Y956_06503| Z169_01232| akap1

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