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  3. AGTR2

AGTR2 (Angiotensin II receptor type 2)

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The Function of AGTR2

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

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Protein names

Recommended name:

Type-2 angiotensin II receptor

Short name:

AT2

Alternative name(s):

Angiotensin II type-2 receptor

AGTR2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1403543 (AGTR2) ??
  2. RS5194 (AGTR2) ??
  3. RS5952223 (AGTR2) ??
  4. RS7879546 (AGTR2) ??

Top Gene-Substance Interactions

AGTR2 Interacts with These Diseases

Disease Score

Substances That Increase AGTR2

Substances Interaction Organism Category

Substances That Decrease AGTR2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • Egr-1
  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • NF-kappaB1
  • IRF-1

Tissue specificity:

In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Renin-angiotensin system

Caution:

Although AGTR2 has been reported to be involved in X-linked mental retardation (PubMed:12089445), its pathological role is questionable (PubMed:23871722).

Molecular Function:

  • Angiotensin Type Ii Receptor Activity
  • Peptide Hormone Binding
  • Receptor Antagonist Activity

Biological Processes:

  • Aldosterone Secretion
  • Blood Vessel Remodeling
  • Brain Development
  • Brain Renin-Angiotensin System
  • Cell Growth Involved In Cardiac Muscle Cell Development
  • Cell Surface Receptor Signaling Pathway
  • Cellular Response To Dexamethasone Stimulus
  • Cellular Sodium Ion Homeostasis
  • Cerebellar Cortex Development
  • Dopamine Biosynthetic Process
  • Exploration Behavior
  • G-Protein Coupled Receptor Signaling Pathway
  • G-Protein Coupled Receptor Signaling Pathway Coupled To Cgmp Nucleotide Second Messenger
  • Inflammatory Response
  • Intracellular Signal Transduction
  • Negative Regulation Of Blood Vessel Endothelial Cell Migration
  • Negative Regulation Of Cell Growth
  • Negative Regulation Of Fibroblast Proliferation
  • Negative Regulation Of Heart Rate
  • Negative Regulation Of Icosanoid Secretion
  • Negative Regulation Of Neurotrophin Trk Receptor Signaling Pathway
  • Negative Regulation Of Norepinephrine Secretion
  • Nitric Oxide Mediated Signal Transduction
  • Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Cytokine Secretion
  • Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Positive Regulation Of Metanephric Glomerulus Development
  • Positive Regulation Of Nitric Oxide Biosynthetic Process
  • Positive Regulation Of Nitric-Oxide Synthase Activity
  • Positive Regulation Of Phosphoprotein Phosphatase Activity
  • Positive Regulation Of Renal Sodium Excretion
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Vasodilation
  • Regulation Of Blood Pressure
  • Regulation Of Metanephros Size
  • Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-Angiotensin
  • Regulation Of Transcription Factor Import Into Nucleus
  • Renin-Angiotensin Regulation Of Aldosterone Production
  • Angiotensin-Mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure

Drug Bank:

  • Tasosartan
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13804| Anapl_15232| angiotensin 2 receptor, type 2| angiotensin II receptor, type 2| angiotensin II subtype 2 receptor, AT2| angiotensin II type 2 receptor| angiotensin II type-2 receptor| angiotensin receptor 2| angiotensin type II receptor| at2| AT2R| AT2-R| AT2 receptor| atgr2| AT<sub>2</sub>R| CB1_002153002| GW7_21704| MDA_GLEAN10003249| mrx88| PAL_GLEAN10000652| PANDA_004168| TREES_T100019059| Type-2 angiotensin II receptor| type-2 angiotensin II receptor-like protein| UY3_03559| Y1Q_009416| agtr2

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