The Function of AGTR2
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
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Protein names
Recommended name:
Type-2 angiotensin II receptorShort name:
AT2Alternative name(s):
Angiotensin II type-2 receptor- RS1403543 (AGTR2) ??
- RS5194 (AGTR2) ??
- RS5952223 (AGTR2) ??
- RS7879546 (AGTR2) ??
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Top Gene-Substance Interactions
AGTR2 Interacts with These Diseases
| Disease | Score |
Substances That Increase AGTR2
| Substances | Interaction | Organism | Category |
Substances That Decrease AGTR2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.
Caution:
Although AGTR2 has been reported to be involved in X-linked mental retardation (PubMed:12089445), its pathological role is questionable (PubMed:23871722).
Molecular Function:
Biological Processes:
- Aldosterone Secretion
- Blood Vessel Remodeling
- Brain Development
- Brain Renin-Angiotensin System
- Cell Growth Involved In Cardiac Muscle Cell Development
- Cell Surface Receptor Signaling Pathway
- Cellular Response To Dexamethasone Stimulus
- Cellular Sodium Ion Homeostasis
- Cerebellar Cortex Development
- Dopamine Biosynthetic Process
- Exploration Behavior
- G-Protein Coupled Receptor Signaling Pathway
- G-Protein Coupled Receptor Signaling Pathway Coupled To Cgmp Nucleotide Second Messenger
- Inflammatory Response
- Intracellular Signal Transduction
- Negative Regulation Of Blood Vessel Endothelial Cell Migration
- Negative Regulation Of Cell Growth
- Negative Regulation Of Fibroblast Proliferation
- Negative Regulation Of Heart Rate
- Negative Regulation Of Icosanoid Secretion
- Negative Regulation Of Neurotrophin Trk Receptor Signaling Pathway
- Negative Regulation Of Norepinephrine Secretion
- Nitric Oxide Mediated Signal Transduction
- Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cytokine Secretion
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
- Positive Regulation Of Metanephric Glomerulus Development
- Positive Regulation Of Nitric Oxide Biosynthetic Process
- Positive Regulation Of Nitric-Oxide Synthase Activity
- Positive Regulation Of Phosphoprotein Phosphatase Activity
- Positive Regulation Of Renal Sodium Excretion
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Vasodilation
- Regulation Of Blood Pressure
- Regulation Of Metanephros Size
- Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-Angiotensin
- Regulation Of Transcription Factor Import Into Nucleus
- Renin-Angiotensin Regulation Of Aldosterone Production
- Angiotensin-Mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure