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  3. AGRP

AGRP (Agouti related neuropeptide)

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The Function of AGRP

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

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Protein names

Recommended name:

Agouti-related protein

AGRP SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS5030980 (AGRP) ??
  2. RS5479 (AGRP) ??

Top Gene-Substance Interactions

AGRP Interacts with These Diseases

Disease Score

Substances That Increase AGRP

Substances Interaction Organism Category

Substances That Decrease AGRP

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: ObesityFrom UniProt: Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. [MIM:601665]

     From NCBI Gene: This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity . [provided by RefSeq, Dec 2009] From UniProt: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • CREB
  • AhR
  • deltaCREB
  • NF-kappaB1
  • c-Fos

Tissue specificity:

Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Adipocytokine signaling pathway

Molecular Function:

  • Neuropeptide Hormone Activity
  • Receptor Binding

Biological Processes:

  • Adult Feeding Behavior
  • Circadian Rhythm
  • Eating Behavior
  • Feeding Behavior
  • Hormone-Mediated Signaling Pathway
  • Long-Day Photoperiodism
  • Maternal Process Involved In Female Pregnancy
  • Neuropeptide Signaling Pathway
  • Positive Regulation Of Feeding Behavior
  • Regulation Of Feeding Behavior
  • Response To Insulin
  • Photoperiodism
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Agouti-related peptide| agouti related protein| agouti-related protein| agouti related protein homolog| agouti related protein homolog (mouse)| agouti related protein-like protein| Agrt| Art| AS27_01858| ASIP2| CB1_000490051| EGK_12895| GW7_02359| H920_18617| M959_14537| MDA_GLEAN10017098| N300_07043| N301_16697| N302_06997| N303_10392| N305_06435| N306_06320| N307_01566| N308_12871| N309_06474| N310_04977| N329_11587| N331_08420| N332_10668| N333_11387| orexigenic neuropeptide| PAL_GLEAN10016230| PANDA_006940| TREES_T100009305| Y1Q_025600| Y956_09270| Z169_06082| agrp

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