The Function of AGRP
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Protein names
Recommended name:
Agouti-related protein- RS5030980 (AGRP) ??
- RS5479 (AGRP) ??
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Top Gene-Substance Interactions
AGRP Interacts with These Diseases
| Disease | Score |
Substances That Increase AGRP
| Substances | Interaction | Organism | Category |
Substances That Decrease AGRP
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: ObesityFrom UniProt: Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. [MIM:601665]
From NCBI Gene: This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity . [provided by RefSeq, Dec 2009] From UniProt: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Molecular Function:
Biological Processes:
- Adult Feeding Behavior
- Circadian Rhythm
- Eating Behavior
- Feeding Behavior
- Hormone-Mediated Signaling Pathway
- Long-Day Photoperiodism
- Maternal Process Involved In Female Pregnancy
- Neuropeptide Signaling Pathway
- Positive Regulation Of Feeding Behavior
- Regulation Of Feeding Behavior
- Response To Insulin
- Photoperiodism