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  3. AGO1

AGO1 (Argonaute 1, RISC catalytic component)

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The Function of AGO1

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

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Protein names

Recommended name:

Protein argonaute-1

Alternative name(s):

Argonaute1
hAgo1
Argonaute RISC catalytic component 1
Eukaryotic translation initiation factor 2C 1
eIF-2C 1
eIF2C 1
Putative RNA-binding protein Q99

AGO1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS636832 (AGO1) ??

Top Gene-Substance Interactions

Substances That Increase AGO1

Substances Interaction Organism Category

Substances That Decrease AGO1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

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