The Function of AGO1
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Protein argonaute-1Alternative name(s):
Argonaute1hAgo1
Argonaute RISC catalytic component 1
Eukaryotic translation initiation factor 2C 1
eIF-2C 1
eIF2C 1
Putative RNA-binding protein Q99
- RS636832 (AGO1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase AGO1
| Substances | Interaction | Organism | Category |
Substances That Decrease AGO1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|