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  3. AGER

AGER (Advanced glycosylation end-product specific receptor)

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The Function of AGER

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

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Protein names

Recommended name:

Advanced glycosylation end product-specific receptor

Alternative name(s):

Receptor for advanced glycosylation end products

AGER SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1800624 (AGER) ??
  2. RS1800625 (AGER) ??
  3. RS2070600 (AGER) ??
  4. RS2071288 (AGER) ??

Top Gene-Substance Interactions

AGER Interacts with These Diseases

Disease Score

Substances That Increase AGER

Substances Interaction Organism Category

Substances That Decrease AGER

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • ER-alpha
  • STAT3
  • NF-kappaB1
  • STAT1
  • STAT1beta
  • STAT1alpha

Tissue specificity:

Endothelial cells.

Gene Pathways:

  • Immune System

Molecular Function:

  • Advanced Glycation End-Product Binding
  • Heparin Binding
  • Receptor Activity
  • S100 Protein Binding
  • Transmembrane Signaling Receptor Activity
  • Advanced Glycation End-Product Receptor Activity
  • Identical Protein Binding

Biological Processes:

  • Astrocyte Development
  • Cell Surface Receptor Signaling Pathway
  • Induction Of Positive Chemotaxis
  • Inflammatory Response
  • Innate Immune Response
  • Negative Regulation Of Advanced Glycation End-Product Receptor Activity
  • Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
  • Negative Regulation Of Interleukin-10 Production
  • Neuron Projection Development
  • Positive Regulation Of Activated T Cell Proliferation
  • Positive Regulation Of Dendritic Cell Differentiation
  • Positive Regulation Of Interleukin-12 Production
  • Positive Regulation Of Jun Kinase Activity
  • Positive Regulation Of Monocyte Chemotactic Protein-1 Production
  • Positive Regulation Of Nf-Kappab Transcription Factor Activity
  • Protein Localization To Membrane
  • Regulation Of Cd4-Positive, Alpha-Beta T Cell Activation
  • Regulation Of Dna Binding
  • Regulation Of T Cell Mediated Cytotoxicity
  • Response To Hypoxia
  • Response To Wounding
  • Brain Development
  • Calcium Ion Homeostasis
  • Cellular Response To Fatty Acid
  • Cellular Response To Glucose Stimulus
  • Cellular Response To Hydrogen Peroxide
  • Cellular Response To Organic Cyclic Compound
  • Glycoprotein Metabolic Process
  • Jak-Stat Cascade
  • Lung Development
  • Negative Regulation Of Cell Adhesion
  • Negative Regulation Of Collagen Biosynthetic Process
  • Negative Regulation Of Endothelial Cell Migration
  • Negative Regulation Of Endothelial Cell Proliferation
  • Negative Regulation Of Osteoblast Proliferation
  • Negative Regulation Of Protein Phosphorylation
  • Positive Regulation Of Autophagy
  • Positive Regulation Of Endothelial Cell Apoptotic Process
  • Positive Regulation Of Epithelial To Mesenchymal Transition
  • Positive Regulation Of Fibroblast Migration
  • Positive Regulation Of Fibroblast Proliferation
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Neuron Apoptotic Process
  • Positive Regulation Of Phagocytosis, Engulfment
  • Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
  • Positive Regulation Of Protein Phosphorylation
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Positive Regulation Of Smooth Muscle Cell Migration
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
  • Response To Fructose
  • Response To Genistein
  • Response To Hyperoxia
  • Response To Methylglyoxal
  • Response To Selenite Ion
  • Response To Vitamin A
  • Transdifferentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| advanced glycation end product receptor| advanced glycation end-products receptor| advanced glycosylation end product-specific receptor| advanced glycosylation end product-specific receptor variant 1| advanced glycosylation end product-specific receptor variant 2| advanced glycosylation end product-specific receptor variant 3| advanced glycosylation end product-specific receptor variant 4| advanced glycosylation end product-specific receptor variant 5| advanced glycosylation end product-specific receptor variant 6| advanced glycosylation end product-specific receptor variant 7| advanced glycosylation end product-specific receptor variant 8| GW7_04815| H920_17572| I79_016422| MDA_GLEAN10005659| PAL_GLEAN10001048| PANDA_019928| RAGE| RAGE/AGER| RAGE isoform NtRAGE-delta| RAGE isoform sRAGE-delta| receptor for advanced glycation end-products variant 20| receptor for advanced glycosylation end products| SCARJ1| TREES_T100017778| ager

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