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  3. AFP

AFP (Alpha fetoprotein)

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The Function of AFP

Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

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Protein names

Recommended name:

Alpha-fetoprotein

Alternative name(s):

Alpha-1-fetoprotein
Alpha-fetoglobulin

AFP SNPs

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  1. RS12506899 (AFP) ??

Top Gene-Substance Interactions

AFP Interacts with These Diseases

Disease Score

Substances That Increase AFP

Substances Interaction Organism Category

Substances That Decrease AFP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • NF-kappaB1
  • Nkx2-5
  • C/EBPalpha
  • HNF-4alpha1
  • HNF-4alpha2
  • GCNF

Tissue specificity:

Plasma. Synthesized by the fetal liver and yolk sac.

Developmental stage:

Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.

Molecular Function:

  • Metal Ion Binding

Biological Processes:

  • Ovulation From Ovarian Follicle
  • Progesterone Metabolic Process
  • Smad Protein Signal Transduction
  • Transport
  • Liver Development
  • Pancreas Development
  • Response To Organic Substance
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

AFPD| alpha-1-fetoprotein| Alpha-fetoglobulin| alpha-fetoprotein| alpha-foetoprotein| chloride intracellular channel 6| FETA| GW7_11086| H920_18018| HPAFP| I79_025221| N334_08595| N340_14273| PAL_GLEAN10004317| PANDA_018507| afp

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