The Function of AFP
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
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Protein names
Recommended name:
Alpha-fetoproteinAlternative name(s):
Alpha-1-fetoproteinAlpha-fetoglobulin
- RS12506899 (AFP) ??
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Top Gene-Substance Interactions
AFP Interacts with These Diseases
| Disease | Score |
Substances That Increase AFP
| Substances | Interaction | Organism | Category |
Substances That Decrease AFP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Plasma. Synthesized by the fetal liver and yolk sac.
Developmental stage:
Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.
Molecular Function:
Biological Processes:
- Ovulation From Ovarian Follicle
- Liver Development
- Transport
- Response To Organic Substance
- Pancreas Development
- Progesterone Metabolic Process
- Smad Protein Signal Transduction