The Function of ADSL
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
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Protein names
Recommended name:
Adenylosuccinate lyaseShort name:
ASLAlternative name(s):
ADSLAdenylosuccinase
ASase
- RS17001868 (ADSL) ??
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Top Gene-Substance Interactions
ADSL Interacts with These Diseases
| Disease | Score |
Substances That Increase ADSL
| Substances | Interaction | Organism | Category |
Substances That Decrease ADSL
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.
Gene Pathways:
Enzyme Regulation:
The enzyme reaction kinetics indicate cooperativity between subunits.
Molecular Function:
- (S)-2-(5-Amino-1-(5-Phospho-D-Ribosyl)Imidazole-4-Carboxamido)Succinate Amp-Lyase (Fumarate-Forming) Activity
- N6-(1,2-Dicarboxyethyl)Amp Amp-Lyase (Fumarate-Forming) Activity
Biological Processes:
- 'De Novo' Amp Biosynthetic Process
- 'De Novo' Imp Biosynthetic Process
- Aerobic Respiration
- Amp Biosynthetic Process
- Protein Tetramerization
- Purine Nucleotide Biosynthetic Process
- Purine Ribonucleoside Monophosphate Biosynthetic Process
- Response To Hypoxia
- Response To Muscle Activity
- Response To Nutrient
- Response To Starvation