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  3. ADSL

ADSL (Adenylosuccinate lyase)

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The Function of ADSL

Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.

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Protein names

Recommended name:

Adenylosuccinate lyase

Short name:

ASL

Alternative name(s):

ADSL
Adenylosuccinase
ASase

ADSL SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17001868 (ADSL) ??

Top Gene-Substance Interactions

ADSL Interacts with These Diseases

Disease Score

Substances That Increase ADSL

Substances Interaction Organism Category

Substances That Decrease ADSL

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • RORalpha2
  • MEF-2A
  • ARP-1

Tissue specificity:

Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Purine metabolism
  • Alanine, aspartate and glutamate metabolism
  • Metabolism

Enzyme Regulation:

The enzyme reaction kinetics indicate cooperativity between subunits.

Molecular Function:

  • (S)-2-(5-Amino-1-(5-Phospho-D-Ribosyl)Imidazole-4-Carboxamido)Succinate Amp-Lyase (Fumarate-Forming) Activity
  • N6-(1,2-Dicarboxyethyl)Amp Amp-Lyase (Fumarate-Forming) Activity

Biological Processes:

  • 'De Novo' Amp Biosynthetic Process
  • 'De Novo' Imp Biosynthetic Process
  • Aerobic Respiration
  • Amp Biosynthetic Process
  • Protein Tetramerization
  • Purine Nucleotide Biosynthetic Process
  • Purine Ribonucleoside Monophosphate Biosynthetic Process
  • Response To Hypoxia
  • Response To Muscle Activity
  • Response To Nutrient
  • Response To Starvation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| adenylosuccinase| adenylosuccinate lyase 1| adenylosuccinate lyase-like protein| adenysuccinate lyase| Adl| AdSL-PA| AMPS| Anapl_15604| AS27_07897| AS28_12502| ASase| ASL| CG3590 gene product from transcript CG3590-RA| CG3590-PA| Dmel_CG3590| fi60b04| GW7_02611| H920_01878| I79_015153| M91_18859| M959_09515| N300_11567| N301_05942| N302_12738| N303_02854| N305_13997| N306_07364| N307_05086| N308_03303| N309_05672| N311_10897| N312_09369| N320_06886| N321_10974| N324_09200| N325_04505| N326_00499| N327_11347| N328_08834| N329_00396| N330_02206| N331_08936| N332_10987| N333_00412| N334_11387| N335_00323| N336_11547| N339_00429| N340_11603| N341_10281| PAL_GLEAN10007252| PANDA_002542| purB| test| Y1Q_016898| Y956_01239| Z169_12066| adsl

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