Summary of ADRB3
The ADRB3 gene encodes adrenoreceptor B3, also called beta-adrenergic receptor 3 [R].
ADRB3 binds mainly to epinephrine. Once activated, it helps burn fat for energy and heat [R].
Variants in ADRB3 have been associated with [R, R, R, R, R]:
- Obesity
- Cholesterol & triglyceride levels
- Coronary artery disease (in Asians)
- Non-alcoholic fatty liver disease (NAFLD)
- Gestational diabetes (high blood sugar during pregnancy)
Protein names
Recommended name:
Beta-3 adrenergic receptorAlternative name(s):
Beta-3 adrenoreceptorBeta-3 adrenoceptor
- RS4994 (ADRB3) ??
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Top Gene-Substance Interactions
ADRB3 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADRB3
| Substances | Interaction | Organism | Category |
Substances That Decrease ADRB3
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Obesity
From NCBI Gene: The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009] From UniProt: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed mainly in adipose tissues.
Gene Pathways:
Molecular Function:
- Beta-Adrenergic Receptor Activity
- Beta3-Adrenergic Receptor Activity
- Protein Homodimerization Activity
- Epinephrine Binding
- Norepinephrine Binding
Biological Processes:
- Temperature Homeostasis
- Diet Induced Thermogenesis
- Vasodilation By Norepinephrine-Epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
- Carbohydrate Metabolic Process
- Generation Of Precursor Metabolites And Energy
- Energy Reserve Metabolic Process
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Activation Of Adenylate Cyclase Activity
- Cell-Cell Signaling
- Aging
- Response To Cold
- Heat Generation
- Negative Regulation Of Multicellular Organism Growth
- Eating Behavior
- Positive Regulation Of Mapk Cascade
- Response To Antibiotic
- Brown Fat Cell Differentiation
- Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
Drug Bank:
- Ephedra
- Isoprenaline
- Arbutamine
- Bethanidine
- Bopindolol
- Bupranolol
- Droxidopa
- Epinephrine
- Fenoterol
- Mephentermine
- Mirabegron
- Nortriptyline
- Olanzapine
- Propranolol
- Trimipramine
- Amitriptyline
- Amphetamine
- Clenbuterol
- Norepinephrine