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  3. ADRB3

ADRB3 (Adrenoceptor beta 3)

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The Function of ADRB3

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

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Protein names

Recommended name:

Beta-3 adrenergic receptor

Alternative name(s):

Beta-3 adrenoreceptor
Beta-3 adrenoceptor

ADRB3 SNPs

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  1. RS4994 (ADRB3) ??

Top Gene-Substance Interactions

ADRB3 Interacts with These Diseases

Disease Score

Substances That Increase ADRB3

Substances Interaction Organism Category

Substances That Decrease ADRB3

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Obesity

     From NCBI Gene: The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009] From UniProt: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • Egr-1
  • PPAR-alpha

Tissue specificity:

Expressed mainly in adipose tissues.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Salivary secretion

Molecular Function:

  • Beta3-Adrenergic Receptor Activity
  • Beta-Adrenergic Receptor Activity
  • Epinephrine Binding
  • Norepinephrine Binding
  • Protein Homodimerization Activity

Biological Processes:

  • Activation Of Adenylate Cyclase Activity
  • Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
  • Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
  • Aging
  • Brown Fat Cell Differentiation
  • Carbohydrate Metabolic Process
  • Cell-Cell Signaling
  • Diet Induced Thermogenesis
  • Eating Behavior
  • Energy Reserve Metabolic Process
  • Generation Of Precursor Metabolites And Energy
  • G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
  • Heat Generation
  • Negative Regulation Of Multicellular Organism Growth
  • Positive Regulation Of Mapk Cascade
  • Response To Antibiotic
  • Response To Cold
  • Temperature Homeostasis
  • Vasodilation By Norepinephrine-Epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure

Drug Bank:

  • Ephedra
  • Isoprenaline
  • Arbutamine
  • Bethanidine
  • Bopindolol
  • Bupranolol
  • Droxidopa
  • Epinephrine
  • Fenoterol
  • Mephentermine
  • Mirabegron
  • Nortriptyline
  • Olanzapine
  • Propranolol
  • Trimipramine
  • Amitriptyline
  • Amphetamine
  • Clenbuterol
  • Norepinephrine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| adrenergic, beta-1-, receptor| A306_10648| ADRB| ADRB1| Adrb-3| ADRB4C| adrenergic, beta 3, receptor| adrenergic, beta-3-, receptor| adrenergic receptor beta 3| adrenergic receptor beta-3| adrenergic receptor, beta 3| adrenoceptor beta 1| AS27_08355| AS28_11702| B3AR| BAR3| beta-1 adrenergic receptor| beta 3 adrenergic receptor| beta3 adrenergic receptor| beta3-adrenergic receptor| Beta-3 adrenergic receptor| beta-3 adrenoceptor| beta3-adrenoceptor| Beta-3 adrenoreceptor| beta 3-AR| Beta-3 AR| BETA3AR| beta-4C adrenergic receptor| beta-4C adrenergic receptor-like| beta-4C adrenergic receptor-like protein| beta-4C adrenoceptor| beta-4C adrenoreceptor| CB1_000667026| Ferritin light chain| GPCR| M91_06457| M959_07314| N303_05428| Nucleoplasmin| PAL_GLEAN10021575| PANDA_005484| Y1Q_031046| Z169_06990| adrb3

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