Summary of ADRB2
The ADRB2 gene encodes the beta-2 adrenergic receptor [R].
ADRB2 becomes activated when epinephrine (adrenaline) binds to it. Epinephrine is the main “fight or flight” brain chemical. Thus, ADRB2 is most commonly studied for its association with anxiety, fear, and mental conditions related to them [R].
Variants in ADRB2 have been associated with [R, R, R, R]:
- Anxiety
- Phobias
- PTSD
- Chronic fatigue
- Asthma
- Obesity
- Diabetes
Protein names
Recommended name:
Beta-2 adrenergic receptorAlternative name(s):
Beta-2 adrenoreceptorBeta-2 adrenoceptor
- RS1042711 (ADRB2) ??
- RS1042713 (ADRB2) ??
- RS1042714 (ADRB2) ??
- RS1042717 (ADRB2) ??
- RS1042718 (ADRB2) ??
- RS1042719 (ADRB2) ??
- RS11959113 (ADRB2) ??
- RS17108911 (ADRB2) ??
- RS1800888 (ADRB2) ??
- RS1801704 (ADRB2) ??
- RS2053044 (ADRB2) ??
- RS2400707 (ADRB2) ??
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Top Gene-Substance Interactions
ADRB2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADRB2
| Substances | Interaction | Organism | Category |
Substances That Decrease ADRB2
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: ObesityAsthma, susceptibility to
From NCBI Gene: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008] From UniProt: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Beta2-Adrenergic Receptor Activity
- Epinephrine Binding
- Norepinephrine Binding
- Potassium Channel Regulator Activity
- Protein Homodimerization Activity
- Dopamine Binding
- Drug Binding
Biological Processes:
- Activation Of Adenylate Cyclase Activity
- Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
- Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Bone Resorption
- Brown Fat Cell Differentiation
- Cell-Cell Signaling
- Cell Surface Receptor Signaling Pathway
- Desensitization Of G-Protein Coupled Receptor Protein Signaling Pathway By Arrestin
- Diet Induced Thermogenesis
- Endosome To Lysosome Transport
- Heat Generation
- Negative Regulation Of Multicellular Organism Growth
- Negative Regulation Of Smooth Muscle Contraction
- Positive Regulation Of Autophagosome Maturation
- Positive Regulation Of Bone Mineralization
- Positive Regulation Of Lipophagy
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Protein Ubiquitination
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Receptor-Mediated Endocytosis
- Regulation Of Sodium Ion Transport
- Regulation Of Vasodilation
- Response To Cold
- Vasodilation By Norepinephrine-Epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
- Aging
- Associative Learning
- Cellular Response To Hypoxia
- Diaphragm Contraction
- Estrous Cycle
- Excitatory Postsynaptic Potential
- Female Pregnancy
- Liver Regeneration
- Negative Regulation Of Angiogenesis
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Ossification
- Negative Regulation Of Platelet Aggregation
- Negative Regulation Of Urine Volume
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Atpase Activity
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
- Positive Regulation Of Potassium Ion Transport
- Positive Regulation Of Skeletal Muscle Tissue Growth
- Positive Regulation Of Sodium Ion Transport
- Positive Regulation Of The Force Of Heart Contraction By Epinephrine
- Positive Regulation Of Vasodilation
- Regulation Of Calcium Ion Transport
- Regulation Of Sensory Perception Of Pain
- Response To Dexamethasone
- Response To Estrogen
- Response To Monoamine
- Response To Progesterone
- Response To Testosterone
- Synaptic Transmission, Glutamatergic
- Wound Healing
Drug Bank:
- Arformoterol
- Ephedra
- Formoterol
- Isoetarine
- Isoprenaline
- Orciprenaline
- Salbutamol
- Salmeterol
- Alprenolol
- Amphetamine
- Arbutamine
- Asenapine
- Atenolol
- Bambuterol
- Bethanidine
- Bevantolol
- Bisoprolol
- Bopindolol
- Cabergoline
- Carteolol
- Carvedilol
- Celiprolol
- Desipramine
- Dipivefrin
- Dobutamine
- Droxidopa
- Fenoterol
- Indacaterol
- Labetalol
- Levobunolol
- Metipranolol
- Mirtazapine
- Nadolol
- Nebivolol
- Norepinephrine
- Olanzapine
- Olodaterol
- Oxprenolol
- Penbutolol
- Pindolol
- Pirbuterol
- Procaterol
- Propranolol
- Pseudoephedrine
- Sotalol
- Terbutaline
- Timolol
- Trimipramine
- Vilanterol
- Phenylpropanolamine
- Acebutolol
- Amitriptyline
- Betaxolol
- Bupranolol
- Clenbuterol
- Epinephrine
- Mephentermine
- Nortriptyline
- Phenoxybenzamine
- Ritodrine
- Metoprolol