Summary of ADRB2
The ADRB2 gene encodes the beta-2 adrenergic receptor [R].
ADRB2 becomes activated when epinephrine (adrenaline) binds to it. Epinephrine is the main “fight or flight” brain chemical. Thus, ADRB2 is most commonly studied for its association with anxiety, fear, and mental conditions related to them [R].
Variants in ADRB2 have been associated with [R, R, R, R]:
- Anxiety
- Phobias
- PTSD
- Chronic fatigue
- Asthma
- Obesity
- Diabetes
Protein names
Recommended name:
Beta-2 adrenergic receptorAlternative name(s):
Beta-2 adrenoreceptorBeta-2 adrenoceptor
- RS1042711 (ADRB2) ??
- RS1042713 (ADRB2) ??
- RS1042714 (ADRB2) ??
- RS1042717 (ADRB2) ??
- RS1042718 (ADRB2) ??
- RS1042719 (ADRB2) ??
- RS11959113 (ADRB2) ??
- RS17108911 (ADRB2) ??
- RS1800888 (ADRB2) ??
- RS1801704 (ADRB2) ??
- RS2053044 (ADRB2) ??
- RS2400707 (ADRB2) ??
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Top Gene-Substance Interactions
ADRB2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADRB2
| Substances | Interaction | Organism | Category |
Substances That Decrease ADRB2
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: ObesityAsthma, susceptibility to
From NCBI Gene: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008] From UniProt: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Beta2-Adrenergic Receptor Activity
- Drug Binding
- Potassium Channel Regulator Activity
- Dopamine Binding
- Protein Homodimerization Activity
- Epinephrine Binding
- Norepinephrine Binding
Biological Processes:
- Diet Induced Thermogenesis
- Vasodilation By Norepinephrine-Epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
- Regulation Of Sodium Ion Transport
- Desensitization Of G-Protein Coupled Receptor Protein Signaling Pathway By Arrestin
- Diaphragm Contraction
- Positive Regulation Of The Force Of Heart Contraction By Epinephrine
- Receptor-Mediated Endocytosis
- Cell Surface Receptor Signaling Pathway
- Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Activation Of Adenylate Cyclase Activity
- Cell-Cell Signaling
- Female Pregnancy
- Aging
- Positive Regulation Of Cell Proliferation
- Associative Learning
- Endosome To Lysosome Transport
- Response To Cold
- Positive Regulation Of Sodium Ion Transport
- Negative Regulation Of Angiogenesis
- Negative Regulation Of Ossification
- Positive Regulation Of Bone Mineralization
- Positive Regulation Of Protein Ubiquitination
- Heat Generation
- Response To Progesterone
- Positive Regulation Of Atpase Activity
- Response To Testosterone
- Synaptic Transmission, Glutamatergic
- Negative Regulation Of Urine Volume
- Negative Regulation Of Multicellular Organism Growth
- Wound Healing
- Regulation Of Vasodilation
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Potassium Ion Transport
- Positive Regulation Of Mapk Cascade
- Response To Estrogen
- Estrous Cycle
- Bone Resorption
- Positive Regulation Of Vasodilation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Smooth Muscle Contraction
- Positive Regulation Of Skeletal Muscle Tissue Growth
- Negative Regulation Of Inflammatory Response
- Brown Fat Cell Differentiation
- Regulation Of Calcium Ion Transport
- Regulation Of Sensory Perception Of Pain
- Excitatory Postsynaptic Potential
- Cellular Response To Hypoxia
- Response To Dexamethasone
- Response To Monoamine
- Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
- Negative Regulation Of Platelet Aggregation
- Liver Regeneration
- Positive Regulation Of Autophagosome Maturation
- Positive Regulation Of Lipophagy
- Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Drug Bank:
- Arformoterol
- Ephedra
- Formoterol
- Isoetarine
- Isoprenaline
- Orciprenaline
- Salbutamol
- Salmeterol
- Alprenolol
- Amphetamine
- Arbutamine
- Asenapine
- Atenolol
- Bambuterol
- Bethanidine
- Bevantolol
- Bisoprolol
- Bopindolol
- Cabergoline
- Carteolol
- Carvedilol
- Celiprolol
- Desipramine
- Dipivefrin
- Dobutamine
- Droxidopa
- Fenoterol
- Indacaterol
- Labetalol
- Levobunolol
- Metipranolol
- Mirtazapine
- Nadolol
- Nebivolol
- Norepinephrine
- Olanzapine
- Olodaterol
- Oxprenolol
- Penbutolol
- Pindolol
- Pirbuterol
- Procaterol
- Propranolol
- Pseudoephedrine
- Sotalol
- Terbutaline
- Timolol
- Trimipramine
- Vilanterol
- Phenylpropanolamine
- Acebutolol
- Amitriptyline
- Betaxolol
- Bupranolol
- Clenbuterol
- Epinephrine
- Mephentermine
- Nortriptyline
- Phenoxybenzamine
- Ritodrine
- Metoprolol