Summary of ADRB2
The Function of ADRB2
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Protein names
Recommended name:
Beta-2 adrenergic receptorAlternative name(s):
Beta-2 adrenoreceptorBeta-2 adrenoceptor
- RS1042711 (ADRB2) ??
- RS1042713 (ADRB2) ??
- RS1042714 (ADRB2) ??
- RS1042717 (ADRB2) ??
- RS1042718 (ADRB2) ??
- RS1042719 (ADRB2) ??
- RS17108911 (ADRB2) ??
- RS1800888 (ADRB2) ??
- RS1801704 (ADRB2) ??
- RS2053044 (ADRB2) ??
- RS2400707 (ADRB2) ??
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Top Gene-Substance Interactions
ADRB2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADRB2
| Substances | Interaction | Organism | Category |
Substances That Decrease ADRB2
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: ObesityAsthma, susceptibility to
From NCBI Gene: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008] From UniProt: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Beta2-Adrenergic Receptor Activity
- Epinephrine Binding
- Norepinephrine Binding
- Potassium Channel Regulator Activity
- Protein Homodimerization Activity
- Dopamine Binding
- Drug Binding
Biological Processes:
- Activation Of Adenylate Cyclase Activity
- Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
- Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Bone Resorption
- Brown Fat Cell Differentiation
- Cell-Cell Signaling
- Cell Surface Receptor Signaling Pathway
- Desensitization Of G-Protein Coupled Receptor Protein Signaling Pathway By Arrestin
- Diet Induced Thermogenesis
- Endosome To Lysosome Transport
- Heat Generation
- Negative Regulation Of Multicellular Organism Growth
- Negative Regulation Of Smooth Muscle Contraction
- Positive Regulation Of Autophagosome Maturation
- Positive Regulation Of Bone Mineralization
- Positive Regulation Of Lipophagy
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Protein Ubiquitination
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Receptor-Mediated Endocytosis
- Regulation Of Sodium Ion Transport
- Regulation Of Vasodilation
- Response To Cold
- Vasodilation By Norepinephrine-Epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
- Aging
- Associative Learning
- Cellular Response To Hypoxia
- Diaphragm Contraction
- Estrous Cycle
- Excitatory Postsynaptic Potential
- Female Pregnancy
- Liver Regeneration
- Negative Regulation Of Angiogenesis
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Ossification
- Negative Regulation Of Platelet Aggregation
- Negative Regulation Of Urine Volume
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Atpase Activity
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
- Positive Regulation Of Potassium Ion Transport
- Positive Regulation Of Skeletal Muscle Tissue Growth
- Positive Regulation Of Sodium Ion Transport
- Positive Regulation Of The Force Of Heart Contraction By Epinephrine
- Positive Regulation Of Vasodilation
- Regulation Of Calcium Ion Transport
- Regulation Of Sensory Perception Of Pain
- Response To Dexamethasone
- Response To Estrogen
- Response To Monoamine
- Response To Progesterone
- Response To Testosterone
- Synaptic Transmission, Glutamatergic
- Wound Healing
Drug Bank:
- Arformoterol
- Ephedra
- Formoterol
- Isoetarine
- Isoprenaline
- Orciprenaline
- Salbutamol
- Salmeterol
- Alprenolol
- Amphetamine
- Arbutamine
- Asenapine
- Atenolol
- Bambuterol
- Bethanidine
- Bevantolol
- Bisoprolol
- Bopindolol
- Cabergoline
- Carteolol
- Carvedilol
- Celiprolol
- Desipramine
- Dipivefrin
- Dobutamine
- Droxidopa
- Fenoterol
- Indacaterol
- Labetalol
- Levobunolol
- Metipranolol
- Mirtazapine
- Nadolol
- Nebivolol
- Norepinephrine
- Olanzapine
- Olodaterol
- Oxprenolol
- Penbutolol
- Pindolol
- Pirbuterol
- Procaterol
- Propranolol
- Pseudoephedrine
- Sotalol
- Terbutaline
- Timolol
- Trimipramine
- Vilanterol
- Phenylpropanolamine
- Acebutolol
- Amitriptyline
- Betaxolol
- Bupranolol
- Clenbuterol
- Epinephrine
- Mephentermine
- Nortriptyline
- Phenoxybenzamine
- Ritodrine
- Metoprolol